🔬 剪接因子 A1CF 靶基因疾病富集分析

疾病名称	Overlap	P-value	富集倍数	相关靶基因
inclusion body myopathy with Paget disease of bone and frontotemporal dementia	2/4	0.001038	35.61x	HNRNPA1, HNRNPA2B1
infection	2/4	0.001038	35.61x	A1CF, CPSF6
idiopathic pulmonary fibrosis	2/5	0.001717	28.49x	A1CF, CPSF6
cancer	4/62	0.006922	4.59x	HNRNPA1, SRSF1, CPSF6, HNRNPA2B1
glioma	4/63	0.007342	4.52x	A1CF, SRSF1, PCBP2, HNRNPA2B1
hepatocellular carcinoma	5/113	0.010858	3.15x	SRSF1, HNRNPA1, CPSF6, HNRNPA2B1, A1CF
adult T-cell leukemia/lymphoma	2/13	0.012628	10.96x	A1CF, HNRNPA2B1
joint disease	2/13	0.012628	10.96x	ZRANB2, PCBP2
severe acute respiratory syndrome	2/14	0.014625	10.17x	HNRNPA1, PCBP2
gout	2/16	0.019004	8.9x	A1CF, PCBP2
Burkitts lymphoma	2/19	0.026489	7.5x	A1CF, HNRNPA2B1
Neurodevelopmental delay	2/19	0.026489	7.5x	HNRNPU, SRSF1
lysosomal storage disease	3/51	0.028330	4.19x	ZRANB2, PCBP2, HNRNPA2B1
amyotrophic lateral sclerosis	2/21	0.032056	6.78x	HNRNPA1, HNRNPA2B1
dengue disease	6/212	0.039747	2.02x	HNRNPU, SRSF1, HNRNPA1, PCBP2, CPSF6, HNRNPA2B1
gastric cancer	2/24	0.041210	5.94x	HNRNPA1, HNRNPA2B1
esophageal carcinoma	2/24	0.041210	5.94x	A1CF, HNRNPA2B1
extranodal nasal NK/T cell lymphoma	2/25	0.044465	5.7x	A1CF, HNRNPA2B1

💡 说明：
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集