🔬 剪接因子 ACIN1 靶基因疾病富集分析

疾病名称	Overlap	P-value	富集倍数	相关靶基因
neurodegenerative disease	173/422	0.000416	1.13x	PSIP1, CHERP, SRSF3, MATR3, HNRNPF, SART3, SAFB2, SF3A1, HTATSF1, RNF20, RBM39, RBM4, SRRM1, NXF1, ZCRB1, CWC22, RBM27, GEMIN5, DHX38, RBMX
hemorrhoid	4/4	0.017172	2.75x	SND1, CCAR2, CCNL1, SFMBT1
hepatocellular carcinoma	51/113	0.021950	1.24x	PSIP1, NONO, SF3B4, YBX1, HNRNPA2B1, PRCC, SRSF3, AGO2, CRNKL1, RBM15, TARDBP, DDX5, KHDRBS1, PABPC1, ZC3H13, FUBP1, SF3B1, ZCCHC8, CPSF6, SPEN
Retinal dystrophy	6/8	0.029914	2.06x	RP9, DHX38, PRPF6, PRPF3, PRPF4, SNRNP200
acute myeloid leukemia	30/63	0.035730	1.31x	PSIP1, NONO, HNRNPA2B1, PRCC, SRSF3, SRSF2, CRNKL1, RBM15, DDX5, PABPC1, FUBP1, SF3B1, ZCCHC8, SPEN, ZCRB1, DDX6, DDX41, NUMA1, RNF213, EWSR1
oral squamous cell carcinoma	19/37	0.039488	1.41x	NONO, HNRNPA2B1, PRCC, CRNKL1, RBM15, DDX5, PABPC1, FUBP1, SF3B1, ZCCHC8, SPEN, DDX6, NUMA1, RNF213, EWSR1, THRAP3, DDX3X, SND1, RBM10
Atypical Meningioma	11/19	0.043248	1.59x	PSIP1, FUS, PABPC1, FUBP1, DDX3X, PRCC, SF3B1, RNF213, SND1, RBM10, DDX5
gastric ulcer	3/3	0.047634	2.75x	RBM33, HNRNPLL, SND1
skin angiosarcoma	3/3	0.047634	2.75x	DDX3X, SND1, RNF213

💡 说明：
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集