🔬 剪接因子 ACIN1 靶基因疾病富集分析

疾病名称	Overlap	P-value	富集倍数	相关靶基因
neurodegenerative disease	173/422	0.000416	1.13x	SF3B1, SRSF1, DHX38, HNRNPK, PRPF38A, RBM17, PRPF19, DDX17, PABPC1, DHX30, LUC7L3, SART3, EIF4B, LSM4, SNRNP70, FAM50A, ZCCHC8, HNRNPC, SRSF7, SRSF11
hemorrhoid	4/4	0.017172	2.75x	SFMBT1, CCNL1, CCAR2, SND1
hepatocellular carcinoma	51/113	0.021950	1.24x	FUS, SF3B1, SRSF1, THRAP3, KHDRBS1, SFPQ, HNRNPK, RNF213, PCBP1, SF3B4, PRPF19, DDX17, PABPC1, EIF4A3, SRSF10, PTBP1, ELAVL1, CRNKL1, EWSR1, ADAR
Retinal dystrophy	6/8	0.029914	2.06x	PRPF3, SNRNP200, DHX38, PRPF4, PRPF6, RP9
acute myeloid leukemia	30/63	0.035730	1.31x	FUS, SF3B1, THRAP3, SFPQ, U2AF2, RNF213, PABPC1, CRNKL1, EWSR1, HNRNPA2B1, RBM15, IGF2BP3, ZCCHC8, NUMA1, U2AF1, ZCRB1, PSIP1, NONO, FUBP1, SRSF2
oral squamous cell carcinoma	19/37	0.039488	1.41x	SF3B1, THRAP3, RNF213, PABPC1, CRNKL1, EWSR1, HNRNPA2B1, RBM15, ZCCHC8, NUMA1, FUBP1, NONO, DDX5, SPEN, RBM10, DDX6, DDX3X, SND1, PRCC
Atypical Meningioma	11/19	0.043248	1.59x	SF3B1, FUS, PABPC1, DDX5, RBM10, PSIP1, RNF213, FUBP1, DDX3X, SND1, PRCC
skin angiosarcoma	3/3	0.047634	2.75x	DDX3X, SND1, RNF213
gastric ulcer	3/3	0.047634	2.75x	RBM33, HNRNPLL, SND1

💡 说明：
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集