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🔬 剪接因子 AQR 靶基因疾病富集分析
| 疾病名称 | Overlap | P-value | 富集倍数 | 相关靶基因 |
|---|---|---|---|---|
| neurodegenerative disease | 187/422 | 0.000010 | 1.15x | SF3B1, SRSF1, RBM38, DHX38, SAMD4B, RBM22, HNRNPK, PRPF38A, MAGOH, RBM17, RBMX2, PRPF19, DDX17, PABPC1, MBNL1, DHX30, LUC7L3, SART3, EIF4B, DHX35 |
| Duodenal Adenocarcinoma | 24/43 | 0.012426 | 1.45x | FUS, SF3B1, ZRSR2, THRAP3, SFPQ, RNF213, CRNKL1, EWSR1, HNRNPA2B1, QKI, ZCCHC8, NUMA1, U2AF1, PSIP1, ZMYM3, FUBP1, NONO, DDX5, SPEN, RBM10 |
| Gastric Adenoma | 15/24 | 0.012841 | 1.63x | ZCCHC8, FUS, NUMA1, ZRSR2, CRNKL1, SPEN, THRAP3, SFPQ, ZMYM3, RNF213, QKI, DDX6, DDX3X, SND1, PRCC |
| oral squamous cell carcinoma | 21/37 | 0.015136 | 1.48x | SF3B1, ZRSR2, THRAP3, RNF213, PABPC1, CRNKL1, EWSR1, HNRNPA2B1, RBM15, QKI, ZCCHC8, NUMA1, NONO, FUBP1, DDX5, SPEN, RBM10, DDX6, DDX3X, SND1 |
| hepatocellular carcinoma | 54/113 | 0.015986 | 1.25x | FUS, SF3B1, SRSF1, ZRSR2, THRAP3, SFPQ, KHDRBS1, HNRNPK, RNF213, SF3B4, PRPF19, DDX17, PABPC1, EIF4A3, SRSF10, PTBP1, ELAVL1, CRNKL1, EWSR1, ADAR |
| melanoma | 29/55 | 0.016962 | 1.37x | FUS, SF3B1, ZRSR2, THRAP3, SFPQ, RNF213, PABPC1, CRNKL1, EWSR1, ADAR, RBM15, YBX1, QKI, ZCCHC8, NUMA1, CDK10, U2AF1, RALY, ZMYM3, NONO |
| brain glioblastoma | 28/53 | 0.018347 | 1.38x | FUS, SF3B1, ZRSR2, THRAP3, SFPQ, RNF213, PABPC1, CRNKL1, EWSR1, HNRNPA2B1, RBM15, QKI, ZCCHC8, NUMA1, U2AF1, PSIP1, ZMYM3, NONO, FUBP1, SRSF2 |
| multiple myeloma | 26/49 | 0.021440 | 1.38x | FUS, SF3B1, ZRSR2, THRAP3, RNF213, PABPC1, CRNKL1, EWSR1, HNRNPA2B1, RBM15, QKI, NUMA1, U2AF1, PSIP1, ZMYM3, NONO, FUBP1, EFTUD2, SRSF2, DDX5 |
| pulmonary large cell neuroendocrine carcinoma | 14/23 | 0.022015 | 1.59x | ZCCHC8, SF3B1, ZRSR2, THRAP3, DDX5, SFPQ, RBM10, HNRNPA2B1, PSIP1, RNF213, FUBP1, DDX3X, SND1, QKI |
| Gallbladder Adenocarcinoma | 21/38 | 0.022142 | 1.44x | FUS, SF3B1, ZRSR2, THRAP3, SFPQ, RNF213, PABPC1, HNRNPA2B1, NUMA1, U2AF1, PSIP1, ZMYM3, FUBP1, NONO, DDX5, SPEN, RBM10, DDX6, DDX3X, SND1 |
| gastric carcinoma | 29/56 | 0.022955 | 1.35x | FUS, SF3B1, ZRSR2, THRAP3, SFPQ, RNF213, PABPC1, CRNKL1, EWSR1, HNRNPA2B1, RBM15, QKI, ZCCHC8, NUMA1, U2AF1, PSIP1, ZMYM3, NONO, FUBP1, DDX19A |
| acute myeloid leukemia | 32/63 | 0.023884 | 1.32x | FUS, SF3B1, ZRSR2, THRAP3, SFPQ, U2AF2, RNF213, PABPC1, CRNKL1, EWSR1, HNRNPA2B1, RBM15, QKI, IGF2BP3, ZCCHC8, NUMA1, U2AF1, PSIP1, ZMYM3, NONO |
| breast carcinoma | 32/63 | 0.023884 | 1.32x | FUS, SF3B1, ZRSR2, THRAP3, SFPQ, RNF213, PABPC1, CRNKL1, EWSR1, ADAR, HNRNPA2B1, RBM15, QKI, FAM50A, ZCCHC8, NUMA1, U2AF1, RALY, PSIP1, ZMYM3 |
| bile duct adenocarcinoma | 24/45 | 0.025012 | 1.39x | FUS, SF3B1, ZRSR2, SFPQ, RNF213, PABPC1, CRNKL1, EWSR1, HNRNPA2B1, RBM15, QKI, NUMA1, U2AF1, PSIP1, ZMYM3, NONO, FUBP1, DDX5, SPEN, RBM10 |
| female breast carcinoma | 19/34 | 0.025420 | 1.46x | FUS, SF3B1, ZRSR2, THRAP3, RNF213, PABPC1, CRNKL1, EWSR1, HNRNPA2B1, QKI, NUMA1, PSIP1, ZMYM3, DDX5, SPEN, RBM10, DDX3X, SND1, PRCC |
| gastric intestinal type adenocarcinoma | 22/41 | 0.029129 | 1.4x | FUS, ZRSR2, THRAP3, RNF213, PABPC1, EWSR1, HNRNPA2B1, RBM15, QKI, NUMA1, U2AF1, ZMYM3, NONO, FUBP1, SRSF2, DDX5, SPEN, RBM10, DDX6, DDX3X |
| central nervous system primitive neuroectodermal neoplasm | 26/50 | 0.029173 | 1.35x | FUS, SF3B1, ZRSR2, THRAP3, SFPQ, RNF213, PABPC1, CRNKL1, EWSR1, HNRNPA2B1, RBM15, QKI, NUMA1, U2AF1, PSIP1, ZMYM3, NONO, FUBP1, SRSF2, DDX5 |
| small cell lung carcinoma | 25/48 | 0.031586 | 1.36x | FUS, SF3B1, ZRSR2, SFPQ, RNF213, PABPC1, CRNKL1, EWSR1, HNRNPA2B1, RBM15, QKI, ZCCHC8, NUMA1, PSIP1, ZMYM3, NONO, FUBP1, SRSF2, DDX5, SPEN |
| thyroid carcinoma | 28/55 | 0.033071 | 1.33x | FUS, SF3B1, ZRSR2, THRAP3, SFPQ, RNF213, PABPC1, CRNKL1, EWSR1, HNRNPA2B1, RBM15, QKI, ZCCHC8, NUMA1, U2AF1, PSIP1, ZMYM3, NONO, FUBP1, SRSF2 |
| lung carcinoma | 28/55 | 0.033071 | 1.33x | FUS, SF3B1, ZRSR2, THRAP3, SFPQ, RNF213, PABPC1, CRNKL1, EWSR1, HNRNPA2B1, QKI, ZCCHC8, NUMA1, U2AF1, RALY, PSIP1, ZMYM3, FUBP1, NONO, SRSF2 |
| skin basal cell carcinoma | 28/55 | 0.033071 | 1.33x | FUS, SF3B1, ZRSR2, THRAP3, SFPQ, RNF213, PABPC1, CRNKL1, EWSR1, HNRNPA2B1, RBM15, QKI, ZCCHC8, NUMA1, U2AF1, PSIP1, ZMYM3, NONO, FUBP1, SRSF2 |
| carcinoma of liver and intrahepatic biliary tract | 28/55 | 0.033071 | 1.33x | FUS, SF3B1, ZRSR2, THRAP3, SFPQ, RNF213, PABPC1, CRNKL1, EWSR1, HNRNPA2B1, RBM15, QKI, ZCCHC8, NUMA1, U2AF1, PSIP1, ZMYM3, NONO, FUBP1, SRSF2 |
| bile duct carcinoma | 28/55 | 0.033071 | 1.33x | FUS, SF3B1, ZRSR2, THRAP3, SFPQ, RNF213, PABPC1, CRNKL1, EWSR1, HNRNPA2B1, RBM15, QKI, ZCCHC8, NUMA1, U2AF1, PSIP1, ZMYM3, NONO, FUBP1, SRSF2 |
| salivary gland adenoid cystic carcinoma | 14/24 | 0.034858 | 1.52x | NUMA1, SF3B1, FUBP1, CRNKL1, SPEN, U2AF1, SFPQ, DDX5, HNRNPA2B1, ZMYM3, NONO, DDX6, DDX3X, SND1 |
| pancreatic neuroendocrine tumor | 19/35 | 0.036476 | 1.41x | SF3B1, ZRSR2, THRAP3, SFPQ, RNF213, CRNKL1, EWSR1, HNRNPA2B1, QKI, ZCCHC8, NUMA1, PSIP1, ZMYM3, SRSF2, SPEN, RBM10, DDX6, SND1, PRCC |
| Ampulla of Vater Carcinoma | 12/20 | 0.038728 | 1.56x | ZCCHC8, SF3B1, U2AF1, SPEN, THRAP3, RBM10, HNRNPA2B1, PSIP1, ZMYM3, RNF213, FUBP1, SND1 |
| Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation | 26/51 | 0.038882 | 1.33x | FUS, SF3B1, ZRSR2, THRAP3, SFPQ, RNF213, PABPC1, CRNKL1, EWSR1, HNRNPA2B1, QKI, ZCCHC8, NUMA1, U2AF1, PSIP1, ZMYM3, FUBP1, NONO, SRSF2, SPEN |
| Retinal dystrophy | 6/8 | 0.039526 | 1.95x | PRPF3, SNRNP200, DHX38, PRPF4, PRPF6, RP9 |
| non-small cell lung carcinoma | 29/58 | 0.039807 | 1.3x | FUS, SF3B1, ZRSR2, THRAP3, SFPQ, RNF213, EWSR1, HNRNPA2B1, YBX1, QKI, ZCCHC8, NUMA1, RBM5, U2AF1, ALYREF, PSIP1, ZMYM3, NONO, FUBP1, AGO2 |
| skin carcinoma | 22/42 | 0.040047 | 1.36x | FUS, SF3B1, ZRSR2, THRAP3, RNF213, PABPC1, CRNKL1, EWSR1, HNRNPA2B1, QKI, ZCCHC8, NUMA1, U2AF1, RALY, PSIP1, SPEN, RBM10, SRSF3, DDX6, DDX3X |
💡 说明：
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集