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🔬 剪接因子 CELF2 靶基因疾病富集分析

疾病名称	Overlap	P-value	富集倍数	相关靶基因
hemorrhoid	4/4	0.005935	3.58x	SND1, CCAR2, CCNL1, SFMBT1
autism	6/9	0.016952	2.39x	THOC2, NONO, FMR1, SNRPN, PPIL2, XRN2
gastric intestinal type adenocarcinoma	18/41	0.017297	1.57x	NONO, FUS, PABPC1, FUBP1, DDX6, DDX3X, HNRNPA2B1, NUMA1, RBM15, RNF213, EWSR1, QKI, SND1, ZMYM3, ZRSR2, SRSF2, THRAP3, DDX5
cancer	25/62	0.018274	1.44x	PSIP1, YBX1, HNRNPA2B1, SRSF3, AGO2, RBM15, DDX5, KHDRBS1, AGGF1, CPSF6, QKI, HNRNPC, PTBP1, RNF213, ELAVL1, IGF2BP3, CCAR2, SRSF1, ZC3HAV1, HNRNPA1
skin angiosarcoma	3/3	0.021513	3.58x	DDX3X, SND1, RNF213
bile duct adenocarcinoma	19/45	0.023189	1.51x	PSIP1, NONO, HNRNPA2B1, SRSF3, RBM15, DDX5, PABPC1, FUBP1, QKI, ZRSR2, DDX6, NUMA1, RNF213, EWSR1, ZMYM3, FUS, DDX3X, SFPQ, SND1
non-small cell lung carcinoma	23/58	0.029096	1.42x	PSIP1, NONO, YBX1, HNRNPA2B1, SRSF3, AGO2, DDX5, ALYREF, FUBP1, QKI, ZRSR2, DDX6, NUMA1, RNF213, EWSR1, ZMYM3, RBM5, THRAP3, FUS, DDX3X
multiple myeloma	20/49	0.029803	1.46x	PSIP1, NONO, HNRNPA2B1, RBM15, DDX5, PABPC1, FUBP1, QKI, ZRSR2, EFTUD2, DDX6, NUMA1, RNF213, EWSR1, ZMYM3, THRAP3, FUS, DDX3X, SND1, SRSF2
pulmonary large cell neuroendocrine carcinoma	11/23	0.030839	1.71x	PSIP1, FUBP1, DDX3X, HNRNPA2B1, RNF213, SFPQ, QKI, SND1, ZRSR2, THRAP3, DDX5
medulloblastoma	6/10	0.032644	2.15x	CCAR1, NONO, DDX6, DDX3X, RNF213, ZMYM3
hepatocellular carcinoma	40/113	0.034890	1.27x	PSIP1, NONO, YBX1, HNRNPA2B1, SRSF3, AGO2, RBM15, TARDBP, DDX5, KHDRBS1, PABPC1, ZC3H13, FUBP1, CPSF6, QKI, HNRNPC, ZRSR2, HNRNPD, PTBP1, DDX6
brain glioblastoma	21/53	0.037053	1.42x	PSIP1, NONO, HNRNPA2B1, SRSF3, RBM15, DDX5, PABPC1, FUBP1, QKI, ZRSR2, DDX6, NUMA1, RNF213, EWSR1, ZMYM3, THRAP3, FUS, DDX3X, SFPQ, SND1
central nervous system primitive neuroectodermal neoplasm	20/50	0.037465	1.43x	PSIP1, NONO, HNRNPA2B1, RBM15, DDX5, PABPC1, FUBP1, QKI, ZRSR2, DDX6, NUMA1, RNF213, EWSR1, ZMYM3, THRAP3, FUS, DDX3X, SFPQ, SND1, SRSF2
Gallbladder Adenocarcinoma	16/38	0.037556	1.51x	PSIP1, NONO, FUS, PABPC1, FUBP1, DDX6, DDX3X, HNRNPA2B1, NUMA1, RNF213, SFPQ, SND1, ZMYM3, ZRSR2, THRAP3, DDX5
chronic lymphocytic leukemia	19/47	0.037751	1.45x	PSIP1, HNRNPA2B1, SRSF3, RBM15, DDX5, FUBP1, QKI, NXF1, ZRSR2, DDX6, NUMA1, RNF213, EWSR1, ZMYM3, THRAP3, FUS, DDX3X, SND1, PCBP1
Gastric Diffuse Large B-Cell Lymphoma	7/13	0.041794	1.93x	PSIP1, FUBP1, DDX3X, RBM15, SND1, ZRSR2, SRSF2
Thyroid Gland Oncocytic Follicular Carcinoma	5/8	0.042284	2.24x	PSIP1, FUS, DDX3X, DDX6, EWSR1
T-cell large granular lymphocyte leukemia	5/8	0.042284	2.24x	DDX6, HNRNPA2B1, SFPQ, EWSR1, SND1
breast carcinoma	24/63	0.042915	1.36x	PSIP1, NONO, HNRNPA2B1, SRSF3, RBM15, DDX5, PABPC1, FUBP1, QKI, ZRSR2, DDX6, NUMA1, RNF213, EWSR1, ZMYM3, THRAP3, ZC3H11A, FUS, DDX3X, RALY
lung adenocarcinoma	24/63	0.042915	1.36x	PSIP1, NONO, YBX1, HNRNPA2B1, SRSF3, RBM15, DDX5, PABPC1, FUBP1, QKI, ZRSR2, DDX6, NUMA1, RNF213, EWSR1, ZMYM3, IGF2BP3, THRAP3, FUS, DDX3X
Gastric Adenoma	11/24	0.043278	1.64x	FUS, DDX6, DDX3X, NUMA1, RNF213, SFPQ, QKI, SND1, ZMYM3, ZRSR2, THRAP3
clear cell renal carcinoma	23/60	0.043914	1.37x	PSIP1, NONO, HNRNPA2B1, PCBP1, SRSF3, RBM15, DDX5, PABPC1, FUBP1, QKI, ZRSR2, DDX6, NUMA1, RNF213, EWSR1, ZMYM3, THRAP3, FUS, DDX3X, SFPQ
small cell lung carcinoma	19/48	0.047161	1.42x	PSIP1, NONO, HNRNPA2B1, RBM15, DDX5, PABPC1, FUBP1, QKI, ZRSR2, DDX6, NUMA1, RNF213, EWSR1, ZMYM3, FUS, DDX3X, SFPQ, SND1, SRSF2
superficial spreading melanoma	18/45	0.047680	1.43x	THRAP3, PSIP1, NONO, FUBP1, DDX6, DDX3X, SRSF3, HNRNPA2B1, NUMA1, RBM15, RNF213, EWSR1, QKI, SND1, ZMYM3, ZRSR2, PCBP1, DDX5

💡 说明：
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集