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🔬 剪接因子 CELF2 靶基因疾病富集分析

疾病名称	Overlap	P-value	富集倍数	相关靶基因
hemorrhoid	4/4	0.005935	3.58x	SFMBT1, CCNL1, CCAR2, SND1
autism	6/9	0.016952	2.39x	PPIL2, SNRPN, THOC2, NONO, FMR1, XRN2
gastric intestinal type adenocarcinoma	18/41	0.017297	1.57x	NUMA1, FUS, SRSF2, ZRSR2, FUBP1, DDX5, THRAP3, EWSR1, HNRNPA2B1, RBM15, ZMYM3, QKI, RNF213, NONO, DDX6, DDX3X, SND1, PABPC1
cancer	25/62	0.018274	1.44x	SRSF1, KHDRBS1, RNF213, AGGF1, ZC3HAV1, ELAVL1, ADAR, CPSF6, HNRNPA2B1, RBM15, YBX1, QKI, IGF2BP3, HNRNPC, HNRNPA1, RALY, PSIP1, AGO2, RBMS1, CCAR2
skin angiosarcoma	3/3	0.021513	3.58x	DDX3X, SND1, RNF213
bile duct adenocarcinoma	19/45	0.023189	1.51x	FUS, ZRSR2, SFPQ, RNF213, PABPC1, EWSR1, HNRNPA2B1, RBM15, QKI, NUMA1, PSIP1, ZMYM3, FUBP1, NONO, DDX5, SRSF3, DDX6, DDX3X, SND1
non-small cell lung carcinoma	23/58	0.029096	1.42x	FUS, ZRSR2, THRAP3, SFPQ, RNF213, EWSR1, HNRNPA2B1, YBX1, QKI, NUMA1, RBM5, ALYREF, PSIP1, ZMYM3, NONO, AGO2, FUBP1, SRSF2, DDX5, SRSF3
multiple myeloma	20/49	0.029803	1.46x	FUS, ZRSR2, THRAP3, RNF213, PABPC1, EWSR1, HNRNPA2B1, RBM15, QKI, NUMA1, PSIP1, ZMYM3, NONO, FUBP1, EFTUD2, SRSF2, DDX5, DDX6, DDX3X, SND1
pulmonary large cell neuroendocrine carcinoma	11/23	0.030839	1.71x	ZRSR2, DDX5, THRAP3, SFPQ, HNRNPA2B1, PSIP1, RNF213, FUBP1, DDX3X, SND1, QKI
medulloblastoma	6/10	0.032644	2.15x	ZMYM3, RNF213, NONO, DDX6, CCAR1, DDX3X
hepatocellular carcinoma	40/113	0.034890	1.27x	FUS, SRSF1, ZRSR2, THRAP3, KHDRBS1, SFPQ, HNRNPK, RNF213, PCBP1, DDX17, PABPC1, SRSF10, ELAVL1, EWSR1, ADAR, CPSF6, HNRNPA2B1, HSPA8, RBM15, YBX1
brain glioblastoma	21/53	0.037053	1.42x	FUS, ZRSR2, THRAP3, SFPQ, RNF213, PABPC1, EWSR1, HNRNPA2B1, RBM15, QKI, NUMA1, PSIP1, ZMYM3, NONO, FUBP1, SRSF2, DDX5, SRSF3, DDX6, DDX3X
central nervous system primitive neuroectodermal neoplasm	20/50	0.037465	1.43x	FUS, ZRSR2, THRAP3, SFPQ, RNF213, PABPC1, EWSR1, HNRNPA2B1, RBM15, QKI, NUMA1, PSIP1, ZMYM3, NONO, FUBP1, SRSF2, DDX5, DDX6, DDX3X, SND1
Gallbladder Adenocarcinoma	16/38	0.037556	1.51x	NUMA1, FUS, ZRSR2, FUBP1, DDX5, THRAP3, SFPQ, HNRNPA2B1, PSIP1, ZMYM3, RNF213, NONO, DDX6, DDX3X, SND1, PABPC1
chronic lymphocytic leukemia	19/47	0.037751	1.45x	FUS, ZRSR2, THRAP3, RNF213, PCBP1, EWSR1, HNRNPA2B1, RBM15, QKI, NUMA1, PSIP1, ZMYM3, FUBP1, DDX5, SRSF3, DDX6, DDX3X, SND1, NXF1
Gastric Diffuse Large B-Cell Lymphoma	7/13	0.041794	1.93x	SRSF2, ZRSR2, FUBP1, PSIP1, RBM15, DDX3X, SND1
Thyroid Gland Oncocytic Follicular Carcinoma	5/8	0.042284	2.24x	FUS, EWSR1, PSIP1, DDX6, DDX3X
T-cell large granular lymphocyte leukemia	5/8	0.042284	2.24x	EWSR1, SFPQ, HNRNPA2B1, DDX6, SND1
lung adenocarcinoma	24/63	0.042915	1.36x	FUS, ZRSR2, THRAP3, SFPQ, RNF213, PCBP1, PABPC1, EWSR1, HNRNPA2B1, RBM15, YBX1, QKI, IGF2BP3, NUMA1, PSIP1, ZMYM3, NONO, FUBP1, SRSF2, DDX5
breast carcinoma	24/63	0.042915	1.36x	FUS, ZRSR2, THRAP3, SFPQ, RNF213, PABPC1, EWSR1, ADAR, HNRNPA2B1, RBM15, QKI, NUMA1, RALY, PSIP1, ZMYM3, NONO, FUBP1, SRSF2, DDX5, ZC3H11A
Gastric Adenoma	11/24	0.043278	1.64x	NUMA1, FUS, ZRSR2, THRAP3, SFPQ, ZMYM3, RNF213, DDX6, DDX3X, SND1, QKI
clear cell renal carcinoma	23/60	0.043914	1.37x	FUS, ZRSR2, THRAP3, SFPQ, RNF213, PCBP1, PABPC1, EWSR1, HNRNPA2B1, RBM15, QKI, NUMA1, SFMBT1, PSIP1, ZMYM3, NONO, FUBP1, SRSF2, DDX5, SRSF3
small cell lung carcinoma	19/48	0.047161	1.42x	FUS, ZRSR2, SFPQ, RNF213, PABPC1, EWSR1, HNRNPA2B1, RBM15, QKI, NUMA1, PSIP1, ZMYM3, FUBP1, NONO, SRSF2, DDX5, DDX6, DDX3X, SND1
superficial spreading melanoma	18/45	0.047680	1.43x	NUMA1, ZRSR2, FUBP1, DDX5, THRAP3, EWSR1, PCBP1, HNRNPA2B1, RBM15, PSIP1, ZMYM3, RNF213, SRSF3, NONO, DDX6, DDX3X, SND1, QKI

💡 说明：
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集