🔬 剪接因子 CPSF1 靶基因疾病富集分析

疾病名称	Overlap	P-value	富集倍数	相关靶基因
neurodegenerative disease	185/422	0.003167	1.1x	PSIP1, CHERP, CDC5L, SRSF3, MATR3, HNRNPF, SART3, SAFB2, SF3A1, HTATSF1, RNF20, RBM39, GPATCH1, SRRM1, THOC5, RBM4, NXF1, RBM22, RBM27, TRNAU1AP
autism	7/9	0.023998	1.95x	THOC2, NONO, FMR1, SNRPN, PPIL2, DHX30, XRN2
hemorrhoid	4/4	0.025083	2.5x	SND1, CCAR2, SFMBT1, CCNL1
coronary atherosclerosis	6/8	0.048362	1.88x	GPATCH3, AGO2, SF3A3, CCNL1, BUD13, ADAR
Gastric Adenoma	14/24	0.049502	1.46x	CPEB3, FUS, DDX6, DDX3X, PRCC, NUMA1, ZCCHC8, SFPQ, QKI, SND1, SPEN, ZMYM3, ZRSR2, THRAP3

💡 说明：
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集