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🔬 剪接因子 CPSF2 靶基因疾病富集分析
| 疾病名称 | Overlap | P-value | 富集倍数 | 相关靶基因 |
|---|---|---|---|---|
| breast carcinoma | 30/63 | 0.003014 | 1.53x | FUS, SF3B1, THRAP3, SFPQ, RNF213, PABPC1, EWSR1, ADAR, HNRNPA2B1, RBM15, QKI, ZCCHC8, NUMA1, RALY, PSIP1, ZMYM3, NONO, FUBP1, CPEB3, SRSF2 |
| small cell lung carcinoma | 24/48 | 0.003667 | 1.6x | FUS, SF3B1, SFPQ, RNF213, PABPC1, EWSR1, HNRNPA2B1, RBM15, QKI, ZCCHC8, NUMA1, PSIP1, ZMYM3, NONO, FUBP1, CPEB3, SRSF2, DDX5, SPEN, RBM10 |
| Gallbladder Adenocarcinoma | 20/38 | 0.003772 | 1.69x | FUS, SF3B1, THRAP3, SFPQ, RNF213, PABPC1, HNRNPA2B1, NUMA1, PSIP1, ZMYM3, FUBP1, NONO, CPEB3, DDX5, SPEN, RBM10, DDX6, DDX3X, SND1, PRCC |
| Duodenal Adenocarcinoma | 22/43 | 0.003773 | 1.64x | FUS, SF3B1, THRAP3, SFPQ, RNF213, EWSR1, HNRNPA2B1, QKI, ZCCHC8, NUMA1, PSIP1, ZMYM3, FUBP1, NONO, CPEB3, DDX5, SPEN, RBM10, DDX6, DDX3X |
| Gastric Adenoma | 14/24 | 0.004642 | 1.87x | ZCCHC8, FUS, NUMA1, THRAP3, SPEN, SFPQ, ZMYM3, RNF213, QKI, DDX6, DDX3X, SND1, PRCC, CPEB3 |
| multiple myeloma | 24/49 | 0.005190 | 1.57x | FUS, SF3B1, THRAP3, RNF213, PABPC1, EWSR1, HNRNPA2B1, RBM15, QKI, NUMA1, PSIP1, ZMYM3, NONO, FUBP1, EFTUD2, CPEB3, SRSF2, DDX5, SPEN, RBM10 |
| female breast carcinoma | 18/34 | 0.005563 | 1.7x | NUMA1, FUS, SF3B1, THRAP3, SPEN, EWSR1, DDX5, RBM10, HNRNPA2B1, PRCC, PSIP1, ZMYM3, RNF213, QKI, DDX3X, SND1, PABPC1, CPEB3 |
| prostate carcinoma | 32/71 | 0.006491 | 1.44x | FUS, SF3B1, THRAP3, SFPQ, RNF213, PABPC1, MBNL1, SRSF10, EWSR1, HNRNPA2B1, RBM15, QKI, ZCCHC8, NUMA1, RALY, PSIP1, ZMYM3, NONO, FUBP1, GPATCH8 |
| Global developmental delay | 12/20 | 0.006496 | 1.92x | DHX30, PABPC1, ELAVL2, DDX5, LSM1, DDX3X, UPF1, ZMYM3, RBM8A, DDX6, SNRNP70, EFTUD2 |
| hepatocellular carcinoma | 47/113 | 0.006636 | 1.33x | FUS, SF3B1, SRSF1, THRAP3, SFPQ, KHDRBS1, HNRNPK, RNF213, SF3B4, DDX17, PABPC1, SRSF10, PTBP1, ELAVL1, EWSR1, ADAR, CPSF6, PPIH, HNRNPA2B1, UPF1 |
| carcinoma of liver and intrahepatic biliary tract | 26/55 | 0.006652 | 1.52x | FUS, SF3B1, THRAP3, SFPQ, RNF213, PABPC1, EWSR1, HNRNPA2B1, RBM15, QKI, ZCCHC8, NUMA1, PSIP1, ZMYM3, NONO, FUBP1, CPEB3, SRSF2, DDX5, SPEN |
| lung carcinoma | 26/55 | 0.006652 | 1.52x | FUS, SF3B1, THRAP3, SFPQ, RNF213, PABPC1, EWSR1, HNRNPA2B1, QKI, ZCCHC8, NUMA1, RALY, PSIP1, ZMYM3, FUBP1, NONO, CPEB3, SRSF2, DDX5, SPEN |
| skin basal cell carcinoma | 26/55 | 0.006652 | 1.52x | FUS, SF3B1, THRAP3, SFPQ, RNF213, PABPC1, EWSR1, HNRNPA2B1, RBM15, QKI, ZCCHC8, NUMA1, PSIP1, ZMYM3, NONO, FUBP1, CPEB3, SRSF2, DDX5, SPEN |
| bile duct carcinoma | 26/55 | 0.006652 | 1.52x | FUS, SF3B1, THRAP3, SFPQ, RNF213, PABPC1, EWSR1, HNRNPA2B1, RBM15, QKI, ZCCHC8, NUMA1, PSIP1, ZMYM3, NONO, FUBP1, CPEB3, SRSF2, DDX5, SPEN |
| thyroid carcinoma | 26/55 | 0.006652 | 1.52x | FUS, SF3B1, THRAP3, SFPQ, RNF213, PABPC1, EWSR1, HNRNPA2B1, RBM15, QKI, ZCCHC8, NUMA1, PSIP1, ZMYM3, NONO, FUBP1, CPEB3, SRSF2, DDX5, SPEN |
| acute myeloid leukemia | 29/63 | 0.006678 | 1.48x | FUS, SF3B1, THRAP3, SFPQ, U2AF2, RNF213, PABPC1, EWSR1, HNRNPA2B1, RBM15, QKI, IGF2BP3, ZCCHC8, NUMA1, PSIP1, ZMYM3, NONO, FUBP1, CPEB3, SRSF2 |
| oral squamous cell carcinoma | 19/37 | 0.006809 | 1.65x | SF3B1, THRAP3, RNF213, PABPC1, EWSR1, HNRNPA2B1, RBM15, QKI, ZCCHC8, NUMA1, FUBP1, NONO, DDX5, SPEN, RBM10, DDX6, DDX3X, SND1, PRCC |
| central nervous system primitive neuroectodermal neoplasm | 24/50 | 0.007207 | 1.54x | FUS, SF3B1, THRAP3, SFPQ, RNF213, PABPC1, EWSR1, HNRNPA2B1, RBM15, QKI, NUMA1, PSIP1, ZMYM3, NONO, FUBP1, CPEB3, SRSF2, DDX5, SPEN, RBM10 |
| brain glioblastoma | 25/53 | 0.008089 | 1.51x | FUS, SF3B1, THRAP3, SFPQ, RNF213, PABPC1, EWSR1, HNRNPA2B1, RBM15, QKI, ZCCHC8, NUMA1, PSIP1, ZMYM3, NONO, FUBP1, SRSF2, DDX5, SPEN, RBM10 |
| pancreatic neuroendocrine tumor | 18/35 | 0.008283 | 1.65x | ZCCHC8, SF3B1, NUMA1, SRSF2, THRAP3, SPEN, EWSR1, SFPQ, RBM10, HNRNPA2B1, PSIP1, ZMYM3, RNF213, QKI, DDX6, SND1, PRCC, CPEB3 |
| papillary thyroid carcinoma | 23/48 | 0.008770 | 1.54x | FUS, SF3B1, THRAP3, SFPQ, RNF213, PABPC1, EWSR1, QKI, ZCCHC8, NUMA1, PSIP1, ZMYM3, FUBP1, NONO, CPEB3, SRSF2, SPEN, RBM10, SRSF3, DDX6 |
| gastric carcinoma | 26/56 | 0.008964 | 1.49x | FUS, SF3B1, THRAP3, SFPQ, RNF213, PABPC1, EWSR1, HNRNPA2B1, RBM15, QKI, ZCCHC8, NUMA1, PSIP1, ZMYM3, NONO, FUBP1, CPEB3, SRSF2, DDX5, SPEN |
| pulmonary large cell neuroendocrine carcinoma | 13/23 | 0.009190 | 1.81x | ZCCHC8, SF3B1, THRAP3, DDX5, SFPQ, RBM10, HNRNPA2B1, PSIP1, RNF213, FUBP1, DDX3X, SND1, QKI |
| Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation | 24/51 | 0.009830 | 1.51x | FUS, SF3B1, THRAP3, SFPQ, RNF213, PABPC1, EWSR1, HNRNPA2B1, QKI, ZCCHC8, NUMA1, PSIP1, ZMYM3, FUBP1, NONO, CPEB3, SRSF2, SPEN, RBM10, SRSF3 |
| gastric intestinal type adenocarcinoma | 20/41 | 0.011411 | 1.56x | FUS, THRAP3, RNF213, PABPC1, EWSR1, HNRNPA2B1, RBM15, QKI, NUMA1, ZMYM3, NONO, FUBP1, SRSF2, DDX5, SPEN, RBM10, DDX6, DDX3X, SND1, PRCC |
| oral cavity carcinoma | 20/41 | 0.011411 | 1.56x | FUS, SF3B1, THRAP3, RNF213, PABPC1, EWSR1, QKI, NUMA1, PSIP1, ZMYM3, FUBP1, NONO, CPEB3, SPEN, RBM10, SRSF3, DDX6, DDX3X, SND1, PRCC |
| medulloblastoma | 7/10 | 0.012740 | 2.24x | SF3B1, ZMYM3, RNF213, NONO, DDX6, CCAR1, DDX3X |
| breast ductal adenocarcinoma | 27/60 | 0.012896 | 1.44x | FUS, SF3B1, THRAP3, SFPQ, RNF213, PABPC1, EWSR1, HNRNPA2B1, RBM15, QKI, ZCCHC8, NUMA1, AKAP1, PSIP1, ZMYM3, NONO, FUBP1, CPEB3, SRSF2, DDX5 |
| clear cell renal carcinoma | 27/60 | 0.012896 | 1.44x | FUS, SF3B1, THRAP3, SFPQ, RNF213, PABPC1, EWSR1, HNRNPA2B1, RBM15, QKI, ZCCHC8, NUMA1, SFMBT1, PSIP1, ZMYM3, NONO, FUBP1, CPEB3, SRSF2, DDX5 |
| ovarian serous adenocarcinoma | 24/52 | 0.013182 | 1.48x | FUS, SF3B1, THRAP3, SFPQ, RNF213, PABPC1, EWSR1, HNRNPA2B1, RBM15, NUMA1, PSIP1, ZMYM3, NONO, FUBP1, CPEB3, SRSF2, DDX5, SPEN, RBM10, SRSF3 |
💡 说明：
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集