🔬 剪接因子 CPSF3 靶基因疾病富集分析

疾病名称	Overlap	P-value	富集倍数	相关靶基因
lysosomal storage disease	23/51	0.014219	1.49x	RBM42, CDC5L, HNRNPA2B1, RNF40, DDX1, SREK1, PCBP2, SNRPF, SF3B1, PLRG1, SPEN, SNRPD3, ZNF207, SSB, SNRPE, ZRANB2, ELAVL2, RBM12, DDX17, AKAP8L
multiple sclerosis	16/33	0.018487	1.6x	ZC3HAV1, DHX30, CDC5L, SSB, SF3B1, DDX1, SREK1, AKAP8L, SNRPE, PLRG1, ELAVL2, PCBP2, SPEN, RBM17, SNRPD3, ZNF207
gastric ulcer	3/3	0.027423	3.3x	RBM33, HNRNPLL, SND1
Hirsutism	3/3	0.027423	3.3x	DHX30, ELAVL2, ZRANB2
oral squamous cell carcinoma	17/37	0.028083	1.52x	NONO, PABPC1, FUBP1, DDX6, DDX3X, PRCC, HNRNPA2B1, CRNKL1, ZCCHC8, SF3B1, EWSR1, QKI, SPEN, SND1, RBM10, THRAP3, DDX5
Gastric Adenoma	12/24	0.030923	1.65x	CPEB3, FUS, DDX6, DDX3X, PRCC, ZCCHC8, CRNKL1, SFPQ, QKI, SPEN, SND1, THRAP3
hepatocellular carcinoma	43/113	0.031987	1.26x	CPEB3, NONO, SF3B4, CDC5L, HNRNPA2B1, PRCC, AGO2, CRNKL1, DDX5, KHDRBS1, PABPC1, ZC3H13, FUBP1, SF3B1, NXT1, ZCCHC8, CPSF6, QKI, SPEN, HNRNPC
Duodenal Adenocarcinoma	19/43	0.032354	1.46x	CPEB3, NONO, HNRNPA2B1, PRCC, CRNKL1, DDX5, FUBP1, SF3B1, ZCCHC8, QKI, SPEN, DDX6, EWSR1, THRAP3, FUS, DDX3X, SFPQ, SND1, RBM10
melanoma	23/55	0.038573	1.38x	CPEB3, NONO, PRCC, CRNKL1, DDX5, PABPC1, FUBP1, SF3B1, ZCCHC8, QKI, CDK10, SPEN, DDX6, EWSR1, THRAP3, FUS, DDX3X, RALY, SFPQ, ADAR
thyroid cancer	9/17	0.040390	1.75x	CELF2, SAMD4A, SNRPG, HNRNPA3, RBPMS, SNRNP48, BUD13, RBM33, FUBP3

💡 说明：
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集