🔬 剪接因子 CPSF3 靶基因疾病富集分析

疾病名称	Overlap	P-value	富集倍数	相关靶基因
lysosomal storage disease	23/51	0.014219	1.49x	SF3B1, SSB, RBM12, ZNF207, CNOT4, DDX17, DHX30, SNRPF, SNRPE, HNRNPA2B1, PLRG1, SREK1, AKAP8L, RNF40, DDX1, GPATCH8, ELAVL2, SPEN, ZRANB2, SNRPD3
multiple sclerosis	16/33	0.018487	1.6x	PLRG1, SF3B1, ZC3HAV1, DHX30, ELAVL2, SPEN, SREK1, AKAP8L, SNRPD3, SSB, PCBP2, SNRPE, RBM17, DDX1, ZNF207, CDC5L
Hirsutism	3/3	0.027423	3.3x	ELAVL2, ZRANB2, DHX30
gastric ulcer	3/3	0.027423	3.3x	RBM33, HNRNPLL, SND1
oral squamous cell carcinoma	17/37	0.028083	1.52x	ZCCHC8, SF3B1, FUBP1, PABPC1, DDX5, SPEN, EWSR1, THRAP3, RBM10, CRNKL1, HNRNPA2B1, QKI, NONO, DDX6, DDX3X, SND1, PRCC
Gastric Adenoma	12/24	0.030923	1.65x	ZCCHC8, FUS, THRAP3, SPEN, SFPQ, CRNKL1, QKI, DDX6, DDX3X, SND1, PRCC, CPEB3
hepatocellular carcinoma	43/113	0.031987	1.26x	FUS, SF3B1, SRSF1, NXT1, THRAP3, KHDRBS1, SFPQ, HNRNPK, PCBP1, SF3B4, PRPF19, DDX17, PABPC1, EIF4A3, SRSF10, PTBP1, ELAVL1, CRNKL1, EWSR1, ADAR
Duodenal Adenocarcinoma	19/43	0.032354	1.46x	FUS, SF3B1, THRAP3, SFPQ, CRNKL1, EWSR1, HNRNPA2B1, QKI, ZCCHC8, FUBP1, NONO, CPEB3, DDX5, SPEN, RBM10, DDX6, DDX3X, SND1, PRCC
melanoma	23/55	0.038573	1.38x	FUS, SF3B1, THRAP3, SFPQ, PABPC1, CRNKL1, EWSR1, ADAR, QKI, ZCCHC8, CDK10, RALY, NONO, FUBP1, CPEB3, SRSF2, DDX5, SPEN, RBM10, DDX6
thyroid cancer	9/17	0.040390	1.75x	RBM33, CELF2, HNRNPA3, SNRNP48, FUBP3, SNRPG, SAMD4A, BUD13, RBPMS

💡 说明：
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集