🔬 剪接因子 GRSF1 靶基因疾病富集分析

疾病名称	Overlap	P-value	富集倍数	相关靶基因
neurodegenerative disease	163/422	0.001941	1.12x	WDR83, CHERP, CDC5L, SRSF3, MATR3, HNRNPF, SART3, SAFB2, SF3A1, HTATSF1, RBM39, SRRM1, THOC5, RBM4, RBM22, RBM27, DHX38, RBMX, DDX6, PRPF19
Global developmental delay	13/20	0.004799	1.88x	LSM1, PABPC1, UPF1, DDX6, DDX3X, DDX5, SNRNP70, CDK10, ZMYM3, DHX30, RBM8A, AAR2, EFTUD2
Intellectual disability	29/57	0.006089	1.47x	HNRNPUL2, AGO2, FAM50A, DDX23, PABPC1, CDK10, SNRPB, HNRNPD, THOC2, FMR1, LSM1, UPF1, DDX6, CSTF2, ZMYM3, HNRNPK, RBM10, PQBP1, SRSF1, EIF4A3
microcephaly	8/12	0.022810	1.92x	DDX3X, RBM28, DHX34, TRA2B, ADAR, DHX30, AAR2, PQBP1
autism	6/9	0.049747	1.92x	THOC2, NONO, FMR1, SNRPN, DHX30, XRN2

💡 说明：
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集