🔬 剪接因子 GRSF1 靶基因疾病富集分析

疾病名称	Overlap	P-value	富集倍数	相关靶基因
neurodegenerative disease	163/422	0.001941	1.12x	RBM15B, SRSF1, RBM38, DHX38, SAMD4B, RBM22, HNRNPK, MAGOH, RBM17, PRPF19, DDX17, PABPC1, MBNL1, LSM6, DHX30, LUC7L3, SART3, EIF4B, SYF2, LSM4
Global developmental delay	13/20	0.004799	1.88x	CDK10, AAR2, PABPC1, DHX30, DDX5, LSM1, SNRNP70, UPF1, ZMYM3, RBM8A, DDX6, DDX3X, EFTUD2
Intellectual disability	29/57	0.006089	1.47x	SNRPB, SRSF1, HNRNPK, U2AF2, FMR1, DDX17, PABPC1, EIF4A3, PQBP1, DHX30, HNRNPUL2, THOC6, UPF1, NOVA2, THOC2, FAM50A, HNRNPU, CDK10, LSM1, ZMYM3
microcephaly	8/12	0.022810	1.92x	PQBP1, AAR2, DHX30, ADAR, DHX34, RBM28, DDX3X, TRA2B
autism	6/9	0.049747	1.92x	DHX30, SNRPN, THOC2, NONO, FMR1, XRN2

💡 说明：
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集