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🔬 剪接因子 HNRNPA1 靶基因疾病富集分析
| 疾病名称 | Overlap | P-value | 富集倍数 | 相关靶基因 |
|---|---|---|---|---|
| Gastric Adenoma | 13/24 | 0.005161 | 1.94x | ZCCHC8, FUS, NUMA1, ZRSR2, THRAP3, SPEN, SFPQ, QKI, RNF213, DDX6, DDX3X, SND1, PRCC |
| hemorrhoid | 4/4 | 0.005935 | 3.58x | SFMBT1, CCNL1, CCAR2, SND1 |
| skin carcinoma | 19/42 | 0.009905 | 1.62x | FUS, SF3B1, ZRSR2, THRAP3, RNF213, A1CF, PABPC1, EWSR1, HNRNPA2B1, QKI, ZCCHC8, NUMA1, RALY, SPEN, SRSF3, DDX6, DDX3X, SND1, PRCC |
| pulmonary large cell neuroendocrine carcinoma | 12/23 | 0.010649 | 1.87x | ZCCHC8, SF3B1, ZRSR2, DDX5, THRAP3, SFPQ, HNRNPA2B1, RNF213, FUBP1, DDX3X, SND1, QKI |
| acute myeloid leukemia | 26/63 | 0.011362 | 1.48x | FUS, SF3B1, ZRSR2, THRAP3, SFPQ, U2AF2, RNF213, A1CF, PABPC1, EWSR1, HNRNPA2B1, QKI, IGF2BP3, ZCCHC8, NUMA1, FUBP1, SRSF2, DDX5, SPEN, DHX34 |
| breast carcinoma | 26/63 | 0.011362 | 1.48x | FUS, SF3B1, ZRSR2, THRAP3, SFPQ, RNF213, A1CF, PABPC1, EWSR1, ADAR, HNRNPA2B1, QKI, ZCCHC8, NUMA1, RALY, FUBP1, SRSF2, DDX5, SPEN, ZC3H11A |
| oral squamous cell carcinoma | 17/37 | 0.012213 | 1.65x | ZCCHC8, SF3B1, NUMA1, ZRSR2, PABPC1, DDX5, SPEN, EWSR1, THRAP3, HNRNPA2B1, QKI, RNF213, FUBP1, DDX6, DDX3X, SND1, PRCC |
| HER2 Positive Breast Carcinoma | 18/40 | 0.012861 | 1.61x | ZCCHC8, SF3B1, NUMA1, SRSF2, ZRSR2, PABPC1, THRAP3, SPEN, EWSR1, SFPQ, HNRNPA2B1, QKI, RNF213, A1CF, DDX6, DDX3X, SND1, PRCC |
| Duodenal Adenocarcinoma | 19/43 | 0.013382 | 1.58x | FUS, SF3B1, ZRSR2, THRAP3, SFPQ, RNF213, A1CF, EWSR1, HNRNPA2B1, QKI, ZCCHC8, NUMA1, FUBP1, DDX5, SPEN, DDX6, DDX3X, SND1, PRCC |
| kidney neoplasm | 21/49 | 0.014089 | 1.53x | FUS, SF3B1, ZRSR2, THRAP3, SFPQ, RNF213, A1CF, PABPC1, EWSR1, HNRNPA2B1, QKI, NUMA1, FUBP1, SRSF2, DDX5, SPEN, SRSF3, DDX6, DDX3X, SND1 |
| melanoma | 23/55 | 0.014427 | 1.5x | FUS, SF3B1, ZRSR2, THRAP3, SFPQ, RNF213, A1CF, PABPC1, EWSR1, ADAR, YBX1, QKI, ZCCHC8, NUMA1, RALY, FUBP1, SRSF2, DDX5, SPEN, DDX6 |
| lung carcinoma | 23/55 | 0.014427 | 1.5x | FUS, SF3B1, ZRSR2, THRAP3, SFPQ, RNF213, A1CF, PABPC1, EWSR1, HNRNPA2B1, QKI, ZCCHC8, NUMA1, RALY, FUBP1, SRSF2, DDX5, SPEN, SRSF3, DDX6 |
| non-small cell lung carcinoma | 24/58 | 0.014484 | 1.48x | FUS, SF3B1, ZRSR2, THRAP3, SFPQ, RNF213, A1CF, EWSR1, HNRNPA2B1, YBX1, QKI, ZCCHC8, NUMA1, RBM5, AGO2, FUBP1, SRSF2, DDX5, SPEN, SRSF3 |
| pancreatic neuroendocrine tumor | 16/35 | 0.015893 | 1.64x | ZCCHC8, SF3B1, NUMA1, SRSF2, ZRSR2, THRAP3, SPEN, EWSR1, SFPQ, HNRNPA2B1, QKI, RNF213, A1CF, DDX6, SND1, PRCC |
| gastric intestinal type adenocarcinoma | 18/41 | 0.017297 | 1.57x | NUMA1, FUS, SRSF2, ZRSR2, PABPC1, DDX5, SPEN, EWSR1, THRAP3, HNRNPA2B1, QKI, RNF213, A1CF, FUBP1, DDX6, DDX3X, SND1, PRCC |
| prostate carcinoma | 28/71 | 0.017602 | 1.41x | FUS, SF3B1, ZRSR2, THRAP3, SFPQ, RNF213, A1CF, PABPC1, MBNL1, SRSF10, EWSR1, HNRNPA2B1, QKI, ZCCHC8, NUMA1, RALY, FUBP1, GPATCH8, SRSF2, DDX5 |
| chronic lymphocytic leukemia | 20/47 | 0.018094 | 1.52x | FUS, SF3B1, ZRSR2, THRAP3, RNF213, A1CF, EWSR1, HNRNPA2B1, QKI, ZCCHC8, NUMA1, FUBP1, DDX5, SPEN, SRSF3, DDX6, DDX3X, SND1, PRCC, NXF1 |
| brain glioblastoma | 22/53 | 0.018422 | 1.49x | FUS, SF3B1, ZRSR2, THRAP3, SFPQ, RNF213, A1CF, PABPC1, EWSR1, HNRNPA2B1, QKI, ZCCHC8, NUMA1, FUBP1, SRSF2, DDX5, SPEN, SRSF3, DDX6, DDX3X |
| skin angiosarcoma | 3/3 | 0.021513 | 3.58x | DDX3X, SND1, RNF213 |
| gastric ulcer | 3/3 | 0.021513 | 3.58x | RBM33, HNRNPLL, SND1 |
| small cell lung carcinoma | 20/48 | 0.023389 | 1.49x | FUS, SF3B1, ZRSR2, SFPQ, RNF213, A1CF, PABPC1, EWSR1, HNRNPA2B1, QKI, ZCCHC8, NUMA1, FUBP1, SRSF2, DDX5, SPEN, DDX6, DDX3X, SND1, PRCC |
| papillary thyroid carcinoma | 20/48 | 0.023389 | 1.49x | FUS, SF3B1, ZRSR2, THRAP3, SFPQ, RNF213, A1CF, PABPC1, EWSR1, QKI, ZCCHC8, NUMA1, FUBP1, SRSF2, SPEN, SRSF3, DDX6, DDX3X, SND1, PRCC |
| Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation | 21/51 | 0.023463 | 1.47x | FUS, SF3B1, ZRSR2, THRAP3, SFPQ, RNF213, A1CF, PABPC1, EWSR1, HNRNPA2B1, QKI, ZCCHC8, NUMA1, FUBP1, SRSF2, SPEN, SRSF3, DDX6, DDX3X, SND1 |
| extranodal nasal NK/T cell lymphoma | 12/25 | 0.023528 | 1.72x | NUMA1, FUS, SF3B1, SPEN, EWSR1, HNRNPA2B1, RNF213, FUBP1, A1CF, DDX3X, SND1, QKI |
| meningioma | 7/12 | 0.025129 | 2.09x | ZCCHC8, FUS, EWSR1, SFPQ, RNF213, FUBP1, DDX3X |
| Merkel cell skin cancer | 14/31 | 0.026855 | 1.62x | ZCCHC8, FUS, SF3B1, ZRSR2, SPEN, EWSR1, SFPQ, RNF213, A1CF, FUBP1, DDX6, DDX3X, SND1, QKI |
| female breast carcinoma | 15/34 | 0.027961 | 1.58x | NUMA1, FUS, SF3B1, ZRSR2, PABPC1, DDX5, SPEN, EWSR1, THRAP3, HNRNPA2B1, QKI, RNF213, DDX3X, SND1, PRCC |
| thyroid carcinoma | 22/55 | 0.029429 | 1.43x | FUS, SF3B1, ZRSR2, THRAP3, SFPQ, RNF213, A1CF, PABPC1, EWSR1, HNRNPA2B1, QKI, ZCCHC8, NUMA1, FUBP1, SRSF2, DDX5, SPEN, SRSF3, DDX6, DDX3X |
| skin basal cell carcinoma | 22/55 | 0.029429 | 1.43x | FUS, SF3B1, ZRSR2, THRAP3, SFPQ, RNF213, A1CF, PABPC1, EWSR1, HNRNPA2B1, QKI, ZCCHC8, NUMA1, FUBP1, SRSF2, DDX5, SPEN, SRSF3, DDX6, DDX3X |
| carcinoma of liver and intrahepatic biliary tract | 22/55 | 0.029429 | 1.43x | FUS, SF3B1, ZRSR2, THRAP3, SFPQ, RNF213, A1CF, PABPC1, EWSR1, HNRNPA2B1, QKI, ZCCHC8, NUMA1, FUBP1, SRSF2, DDX5, SPEN, SRSF3, DDX6, DDX3X |
💡 说明：
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集