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🔬 剪接因子 HNRNPF 靶基因疾病富集分析

疾病名称	Overlap	P-value	富集倍数	相关靶基因
hepatocellular carcinoma	20/113	0.000005	2.64x	PSIP1, NONO, HNRNPA2B1, PRCC, RBM15, KHDRBS1, PABPC1, FUBP1, CPSF6, SPEN, PTBP1, HNRNPD, HSPA8, HNRNPK, SRSF1, DDX17, HNRNPA1, DDX3X, SFPQ, SRSF2
acute myeloid leukemia	13/63	0.000084	3.08x	PSIP1, NONO, PABPC1, FUBP1, HNRNPA2B1, DDX3X, U2AF2, PRCC, RBM15, SFPQ, SPEN, ZCRB1, SRSF2
small cell lung carcinoma	11/48	0.000125	3.42x	PSIP1, NONO, PABPC1, FUBP1, HNRNPA2B1, DDX3X, PRCC, RBM15, SFPQ, SPEN, SRSF2
central nervous system primitive neuroectodermal neoplasm	11/50	0.000186	3.28x	PSIP1, NONO, PABPC1, FUBP1, HNRNPA2B1, DDX3X, PRCC, RBM15, SFPQ, SPEN, SRSF2
ovarian serous adenocarcinoma	11/52	0.000273	3.15x	PSIP1, NONO, PABPC1, FUBP1, HNRNPA2B1, DDX3X, PRCC, RBM15, SFPQ, SPEN, SRSF2
head and neck squamous cell carcinoma	12/61	0.000282	2.93x	PSIP1, KHDRBS1, NONO, PABPC1, FUBP1, HNRNPA2B1, DDX3X, PRCC, RBM15, SFPQ, SPEN, SRSF2
brain glioblastoma	11/53	0.000328	3.09x	PSIP1, NONO, PABPC1, FUBP1, HNRNPA2B1, DDX3X, PRCC, RBM15, SFPQ, SPEN, SRSF2
breast carcinoma	12/63	0.000391	2.84x	PSIP1, ZC3H11A, NONO, PABPC1, FUBP1, HNRNPA2B1, DDX3X, PRCC, RBM15, SFPQ, SPEN, SRSF2
Gallbladder Adenocarcinoma	9/38	0.000450	3.53x	PSIP1, NONO, PABPC1, FUBP1, HNRNPA2B1, DDX3X, PRCC, SFPQ, SPEN
carcinoma of liver and intrahepatic biliary tract	11/55	0.000465	2.98x	PSIP1, NONO, PABPC1, FUBP1, HNRNPA2B1, DDX3X, PRCC, RBM15, SFPQ, SPEN, SRSF2
skin basal cell carcinoma	11/55	0.000465	2.98x	PSIP1, NONO, PABPC1, FUBP1, HNRNPA2B1, DDX3X, PRCC, RBM15, SFPQ, SPEN, SRSF2
bile duct carcinoma	11/55	0.000465	2.98x	PSIP1, NONO, PABPC1, FUBP1, HNRNPA2B1, DDX3X, PRCC, RBM15, SFPQ, SPEN, SRSF2
thyroid carcinoma	11/55	0.000465	2.98x	PSIP1, NONO, PABPC1, FUBP1, HNRNPA2B1, DDX3X, PRCC, RBM15, SFPQ, SPEN, SRSF2
gastric carcinoma	11/56	0.000551	2.93x	PSIP1, NONO, PABPC1, FUBP1, HNRNPA2B1, DDX3X, PRCC, RBM15, SFPQ, SPEN, SRSF2
multiple myeloma	10/49	0.000755	3.04x	PSIP1, NONO, PABPC1, FUBP1, DDX3X, HNRNPA2B1, PRCC, RBM15, SPEN, SRSF2
rectal adenocarcinoma	11/58	0.000762	2.83x	PSIP1, NONO, PABPC1, FUBP1, HNRNPA2B1, DDX3X, PRCC, RBM15, SFPQ, SPEN, SRSF2
gastric intestinal type adenocarcinoma	9/41	0.000830	3.27x	NONO, PABPC1, FUBP1, DDX3X, HNRNPA2B1, PRCC, RBM15, SPEN, SRSF2
gastric adenocarcinoma	11/59	0.000891	2.78x	PSIP1, NONO, PABPC1, FUBP1, HNRNPA2B1, DDX3X, PRCC, RBM15, SFPQ, SPEN, SRSF2
colorectal adenocarcinoma	11/59	0.000891	2.78x	PSIP1, NONO, PABPC1, FUBP1, HNRNPA2B1, DDX3X, PRCC, RBM15, SFPQ, SPEN, SRSF2
pancreatic ductal adenocarcinoma	11/59	0.000891	2.78x	PSIP1, NONO, PABPC1, FUBP1, HNRNPA2B1, DDX3X, PRCC, RBM15, SFPQ, SPEN, SRSF2
bladder transitional cell carcinoma	11/59	0.000891	2.78x	PSIP1, NONO, PABPC1, FUBP1, HNRNPA2B1, DDX3X, PRCC, RBM15, SFPQ, SPEN, SRSF2
colon adenocarcinoma	11/59	0.000891	2.78x	PSIP1, NONO, PABPC1, FUBP1, HNRNPA2B1, DDX3X, PRCC, RBM15, SFPQ, SPEN, SRSF2
Endometrial Endometrioid Adenocarcinoma	11/59	0.000891	2.78x	PSIP1, NONO, PABPC1, FUBP1, HNRNPA2B1, DDX3X, PRCC, RBM15, SFPQ, SPEN, SRSF2
Gastric Diffuse Large B-Cell Lymphoma	5/13	0.000928	5.73x	PSIP1, FUBP1, DDX3X, RBM15, SRSF2
breast ductal adenocarcinoma	11/60	0.001037	2.73x	PSIP1, NONO, PABPC1, FUBP1, HNRNPA2B1, DDX3X, PRCC, RBM15, SFPQ, SPEN, SRSF2
clear cell renal carcinoma	11/60	0.001037	2.73x	PSIP1, NONO, PABPC1, FUBP1, HNRNPA2B1, DDX3X, PRCC, RBM15, SFPQ, SPEN, SRSF2
Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation	10/51	0.001062	2.92x	PSIP1, NONO, PABPC1, FUBP1, HNRNPA2B1, DDX3X, PRCC, SFPQ, SPEN, SRSF2
prostate adenocarcinoma	11/61	0.001204	2.69x	PSIP1, NONO, PABPC1, FUBP1, HNRNPA2B1, DDX3X, PRCC, RBM15, SFPQ, SPEN, SRSF2
squamous cell lung carcinoma	11/61	0.001204	2.69x	PSIP1, NONO, PABPC1, FUBP1, HNRNPA2B1, DDX3X, PRCC, RBM15, SFPQ, SPEN, SRSF2
cutaneous melanoma	11/61	0.001204	2.69x	PSIP1, NONO, PABPC1, FUBP1, HNRNPA2B1, DDX3X, PRCC, RBM15, SFPQ, SPEN, SRSF2

💡 说明：
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集