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🔬 剪接因子 HNRNPF 靶基因疾病富集分析

疾病名称 Overlap P-value 富集倍数 相关靶基因
hepatocellular carcinoma 20/113 0.000005 2.64x SRSF1, KHDRBS1, SFPQ, HNRNPK, DDX17, PABPC1, PTBP1, CPSF6, HNRNPA2B1, HSPA8, RBM15, HNRNPA1, PSIP1, NONO, FUBP1, SRSF2, SPEN, HNRNPD, DDX3X, PRCC
acute myeloid leukemia 13/63 0.000084 3.08x NONO, SRSF2, FUBP1, ZCRB1, SPEN, SFPQ, HNRNPA2B1, PRCC, U2AF2, PSIP1, RBM15, DDX3X, PABPC1
small cell lung carcinoma 11/48 0.000125 3.42x NONO, SRSF2, FUBP1, SPEN, SFPQ, HNRNPA2B1, PRCC, PSIP1, RBM15, DDX3X, PABPC1
central nervous system primitive neuroectodermal neoplasm 11/50 0.000186 3.28x NONO, SRSF2, FUBP1, SPEN, SFPQ, HNRNPA2B1, PRCC, PSIP1, RBM15, DDX3X, PABPC1
ovarian serous adenocarcinoma 11/52 0.000273 3.15x NONO, SRSF2, FUBP1, SPEN, SFPQ, HNRNPA2B1, PRCC, PSIP1, RBM15, DDX3X, PABPC1
head and neck squamous cell carcinoma 12/61 0.000282 2.93x NONO, SRSF2, FUBP1, SPEN, KHDRBS1, SFPQ, HNRNPA2B1, PRCC, PSIP1, RBM15, DDX3X, PABPC1
brain glioblastoma 11/53 0.000328 3.09x NONO, SRSF2, FUBP1, SPEN, SFPQ, HNRNPA2B1, PRCC, PSIP1, RBM15, DDX3X, PABPC1
breast carcinoma 12/63 0.000391 2.84x NONO, SRSF2, FUBP1, SPEN, ZC3H11A, SFPQ, HNRNPA2B1, PRCC, PSIP1, RBM15, DDX3X, PABPC1
Gallbladder Adenocarcinoma 9/38 0.000450 3.53x FUBP1, SPEN, SFPQ, HNRNPA2B1, PRCC, PSIP1, NONO, DDX3X, PABPC1
carcinoma of liver and intrahepatic biliary tract 11/55 0.000465 2.98x NONO, SRSF2, FUBP1, SPEN, SFPQ, HNRNPA2B1, PRCC, PSIP1, RBM15, DDX3X, PABPC1
skin basal cell carcinoma 11/55 0.000465 2.98x NONO, SRSF2, FUBP1, SPEN, SFPQ, HNRNPA2B1, PRCC, PSIP1, RBM15, DDX3X, PABPC1
bile duct carcinoma 11/55 0.000465 2.98x NONO, SRSF2, FUBP1, SPEN, SFPQ, HNRNPA2B1, PRCC, PSIP1, RBM15, DDX3X, PABPC1
thyroid carcinoma 11/55 0.000465 2.98x NONO, SRSF2, FUBP1, SPEN, SFPQ, HNRNPA2B1, PRCC, PSIP1, RBM15, DDX3X, PABPC1
gastric carcinoma 11/56 0.000551 2.93x NONO, SRSF2, FUBP1, SPEN, SFPQ, HNRNPA2B1, PRCC, PSIP1, RBM15, DDX3X, PABPC1
multiple myeloma 10/49 0.000755 3.04x NONO, SRSF2, FUBP1, SPEN, HNRNPA2B1, PRCC, PSIP1, RBM15, DDX3X, PABPC1
rectal adenocarcinoma 11/58 0.000762 2.83x NONO, SRSF2, FUBP1, SPEN, SFPQ, HNRNPA2B1, PRCC, PSIP1, RBM15, DDX3X, PABPC1
gastric intestinal type adenocarcinoma 9/41 0.000830 3.27x NONO, SRSF2, FUBP1, SPEN, HNRNPA2B1, PRCC, RBM15, DDX3X, PABPC1
gastric adenocarcinoma 11/59 0.000891 2.78x NONO, SRSF2, FUBP1, SPEN, SFPQ, HNRNPA2B1, PRCC, PSIP1, RBM15, DDX3X, PABPC1
colorectal adenocarcinoma 11/59 0.000891 2.78x NONO, SRSF2, FUBP1, SPEN, SFPQ, HNRNPA2B1, PRCC, PSIP1, RBM15, DDX3X, PABPC1
pancreatic ductal adenocarcinoma 11/59 0.000891 2.78x NONO, SRSF2, FUBP1, SPEN, SFPQ, HNRNPA2B1, PRCC, PSIP1, RBM15, DDX3X, PABPC1
bladder transitional cell carcinoma 11/59 0.000891 2.78x NONO, SRSF2, FUBP1, SPEN, SFPQ, HNRNPA2B1, PRCC, PSIP1, RBM15, DDX3X, PABPC1
colon adenocarcinoma 11/59 0.000891 2.78x NONO, SRSF2, FUBP1, SPEN, SFPQ, HNRNPA2B1, PRCC, PSIP1, RBM15, DDX3X, PABPC1
Endometrial Endometrioid Adenocarcinoma 11/59 0.000891 2.78x NONO, SRSF2, FUBP1, SPEN, SFPQ, HNRNPA2B1, PRCC, PSIP1, RBM15, DDX3X, PABPC1
Gastric Diffuse Large B-Cell Lymphoma 5/13 0.000928 5.73x SRSF2, FUBP1, PSIP1, RBM15, DDX3X
breast ductal adenocarcinoma 11/60 0.001037 2.73x NONO, SRSF2, FUBP1, SPEN, SFPQ, HNRNPA2B1, PRCC, PSIP1, RBM15, DDX3X, PABPC1
clear cell renal carcinoma 11/60 0.001037 2.73x NONO, SRSF2, FUBP1, SPEN, SFPQ, HNRNPA2B1, PRCC, PSIP1, RBM15, DDX3X, PABPC1
Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation 10/51 0.001062 2.92x SRSF2, FUBP1, SPEN, SFPQ, HNRNPA2B1, PRCC, PSIP1, NONO, DDX3X, PABPC1
prostate adenocarcinoma 11/61 0.001204 2.69x NONO, SRSF2, FUBP1, SPEN, SFPQ, HNRNPA2B1, PRCC, PSIP1, RBM15, DDX3X, PABPC1
squamous cell lung carcinoma 11/61 0.001204 2.69x NONO, SRSF2, FUBP1, SPEN, SFPQ, HNRNPA2B1, PRCC, PSIP1, RBM15, DDX3X, PABPC1
cutaneous melanoma 11/61 0.001204 2.69x NONO, SRSF2, FUBP1, SPEN, SFPQ, HNRNPA2B1, PRCC, PSIP1, RBM15, DDX3X, PABPC1
💡 说明：
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集