🔬 剪接因子 HNRNPH1 靶基因疾病富集分析

疾病名称	Overlap	P-value	富集倍数	相关靶基因
Intellectual disability	29/57	0.001481	1.59x	SNRPB, SRSF1, HNRNPK, U2AF2, SF3B4, FMR1, DDX17, PABPC1, EIF4A3, DHX30, HNRNPUL2, THOC6, ZFR, UPF1, THOC2, FAM50A, HNRNPU, PUF60, CDK10, ZMYM3
hemorrhoid	4/4	0.010253	3.13x	SFMBT1, CCNL1, CCAR2, SND1
neurodegenerative disease	148/422	0.012051	1.1x	SRSF1, SAMD4B, HNRNPK, MAGOH, RBM17, PRPF19, DDX17, PABPC1, WBP4, DHX30, LUC7L3, EIF4B, LSM4, SNRNP70, FAM50A, HNRNPC, SRSF7, SRSF11, CD2BP2, DDX21
genetic disorder	46/113	0.019863	1.27x	FUS, SNRPB, SRSF1, HNRNPK, IK, U2AF2, RNF213, SF3B4, PRPF19, FMR1, RNF34, EIF4A3, DHX30, HNRNPUL2, THOC6, ADAR, HNRNPA2B1, THOC2, FAM50A, HNRNPU
skin angiosarcoma	3/3	0.032385	3.13x	SND1, DDX3X, RNF213
autism	6/9	0.033677	2.08x	DHX30, PPIL2, SNRPN, THOC2, FMR1, XRN2
Gastric Adenoma	12/24	0.047190	1.56x	NUMA1, FUS, THRAP3, SPEN, SFPQ, ZMYM3, RNF213, QKI, DDX6, DDX3X, SND1, PRCC

💡 说明：
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集