🔬 剪接因子 HNRNPH1 靶基因疾病富集分析

疾病名称	Overlap	P-value	富集倍数	相关靶基因
Intellectual disability	29/57	0.001481	1.59x	SF3B4, HNRNPUL2, AGO2, FAM50A, DDX23, PABPC1, CDK10, PUF60, SNRPB, HNRNPD, THOC2, FMR1, UPF1, DDX6, ZFR, ZMYM3, HNRNPK, RBM10, SRSF1, EIF4A3
hemorrhoid	4/4	0.010253	3.13x	SND1, CCAR2, SFMBT1, CCNL1
neurodegenerative disease	148/422	0.012051	1.1x	WDR83, CHERP, SRSF3, MATR3, HNRNPF, SAFB2, SF3A1, HTATSF1, RBM39, RBM4, THOC5, NXF1, RBM27, TRNAU1AP, DDX6, PRPF19, SNRNP35, SNRPE, TRA2A, RBM12B
genetic disorder	46/113	0.019863	1.27x	SF3B4, HNRNPUL2, HNRNPA2B1, AGO2, MATR3, RAVER1, TARDBP, FAM50A, DDX23, FRA10AC1, CDK10, SPEN, HNRNPC, PUF60, SNRPB, THOC2, FMR1, RNF34, DDX6, PRPF19
skin angiosarcoma	3/3	0.032385	3.13x	DDX3X, SND1, RNF213
autism	6/9	0.033677	2.08x	THOC2, FMR1, SNRPN, PPIL2, DHX30, XRN2
Gastric Adenoma	12/24	0.047190	1.56x	FUS, DDX6, PRCC, DDX3X, NUMA1, RNF213, SFPQ, QKI, SND1, SPEN, ZMYM3, THRAP3

💡 说明：
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集