🔬 剪接因子 HNRNPK 靶基因疾病富集分析

疾病名称	Overlap	P-value	富集倍数	相关靶基因
Intellectual disability	29/57	0.012539	1.41x	SF3B4, HNRNPUL2, AGO2, FAM50A, DDX23, PABPC1, CDK10, PUF60, SNRPB, HNRNPD, THOC2, FMR1, LSM1, UPF1, DDX6, ZFR, ZMYM3, HNRNPK, RBM10, PQBP1
autism	7/9	0.013167	2.15x	THOC2, NONO, FMR1, SNRPN, PPIL2, DHX30, XRN2
Global developmental delay	12/20	0.023942	1.66x	LSM1, PABPC1, UPF1, DDX6, DDX3X, DDX5, SNRNP70, CDK10, ZMYM3, DHX30, AAR2, EFTUD2
microcephaly	8/12	0.030144	1.84x	DDX3X, RBM28, DHX34, TRA2B, ADAR, DHX30, AAR2, PQBP1
gastric intestinal type adenocarcinoma	21/41	0.030295	1.42x	NONO, HNRNPA2B1, PRCC, SRSF2, DDX5, PABPC1, FUBP1, QKI, SPEN, DDX6, NUMA1, RNF213, EWSR1, A1CF, ZMYM3, THRAP3, FUS, DDX3X, SND1, RBM10
acrocephalosyndactyly	3/3	0.047021	2.76x	NCBP1, POLR2G, NCBP2
skin angiosarcoma	3/3	0.047021	2.76x	DDX3X, SND1, RNF213

💡 说明：
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集