🔬 剪接因子 HNRNPK 靶基因疾病富集分析

疾病名称	Overlap	P-value	富集倍数	相关靶基因
Intellectual disability	29/57	0.012539	1.41x	SNRPB, SRSF1, HNRNPK, U2AF2, SF3B4, FMR1, DDX17, PABPC1, PQBP1, DHX30, HNRNPUL2, ZFR, UPF1, THOC2, FAM50A, HNRNPU, PUF60, CDK10, LSM1, ZMYM3
autism	7/9	0.013167	2.15x	DHX30, PPIL2, SNRPN, THOC2, NONO, FMR1, XRN2
Global developmental delay	12/20	0.023942	1.66x	CDK10, AAR2, PABPC1, DHX30, DDX5, LSM1, SNRNP70, UPF1, ZMYM3, DDX6, DDX3X, EFTUD2
microcephaly	8/12	0.030144	1.84x	PQBP1, AAR2, DHX30, ADAR, DHX34, RBM28, DDX3X, TRA2B
gastric intestinal type adenocarcinoma	21/41	0.030295	1.42x	FUS, THRAP3, RNF213, A1CF, PABPC1, EWSR1, HNRNPA2B1, QKI, NUMA1, U2AF1, ZMYM3, FUBP1, NONO, SRSF2, DDX5, SPEN, RBM10, DDX6, DDX3X, SND1
skin angiosarcoma	3/3	0.047021	2.76x	SND1, DDX3X, RNF213
acrocephalosyndactyly	3/3	0.047021	2.76x	NCBP2, POLR2G, NCBP1

💡 说明：
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集