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🔬 剪接因子 HNRNPL 靶基因疾病富集分析
| 疾病名称 | Overlap | P-value | 富集倍数 | 相关靶基因 |
|---|---|---|---|---|
| pulmonary large cell neuroendocrine carcinoma | 13/23 | 0.007967 | 1.84x | PSIP1, FUBP1, DDX3X, HNRNPA2B1, SF3B1, ZCCHC8, RNF213, SFPQ, QKI, SND1, RBM10, THRAP3, DDX5 |
| coronary atherosclerosis | 6/8 | 0.012346 | 2.44x | AGO2, SF3A3, CCNL1, BUD13, ADAR, CPEB4 |
| Duodenal Adenocarcinoma | 20/43 | 0.017877 | 1.51x | PSIP1, NONO, HNRNPA2B1, DDX5, FUBP1, SF3B1, ZCCHC8, QKI, SPEN, DDX6, NUMA1, RNF213, EWSR1, THRAP3, DDX3X, SFPQ, U2AF1, SND1, RBM10, A1CF |
| Ampulla of Vater Carcinoma | 11/20 | 0.018981 | 1.79x | PSIP1, FUBP1, HNRNPA2B1, SF3B1, ZCCHC8, RNF213, SND1, SPEN, RBM10, U2AF1, THRAP3 |
| response to stimulus | 6/9 | 0.027608 | 2.17x | PTBP2, CWC27, ZRANB2, BUD13, KHDRBS3, CWC22 |
| gastric ulcer | 3/3 | 0.028722 | 3.25x | SND1, RBM33, HNRNPLL |
| skin angiosarcoma | 3/3 | 0.028722 | 3.25x | DDX3X, SND1, RNF213 |
| skin carcinoma | 19/42 | 0.029066 | 1.47x | PSIP1, HNRNPA2B1, SRSF3, PABPC1, SF3B1, ZCCHC8, QKI, SPEN, DDX6, NUMA1, RNF213, EWSR1, THRAP3, DDX3X, RALY, U2AF1, SND1, RBM10, A1CF |
| small intestinal neuroendocrine tumor G1 | 5/7 | 0.031214 | 2.32x | PSIP1, DDX6, RNF213, RBM10, U2AF1 |
| superficial spreading melanoma | 20/45 | 0.031233 | 1.45x | PSIP1, NONO, HNRNPA2B1, SRSF3, DDX5, FUBP1, SF3B1, QKI, SPEN, DDX6, NUMA1, RNF213, EWSR1, THRAP3, DDX3X, U2AF1, SND1, RBM10, A1CF, PCBP1 |
| oral squamous cell carcinoma | 17/37 | 0.032659 | 1.49x | NONO, PABPC1, FUBP1, DDX3X, DDX6, HNRNPA2B1, SF3B1, NUMA1, ZCCHC8, RNF213, EWSR1, QKI, SND1, SPEN, RBM10, THRAP3, DDX5 |
| salivary gland adenoid cystic carcinoma | 12/24 | 0.034851 | 1.63x | NONO, FUBP1, DDX3X, DDX6, HNRNPA2B1, SF3B1, NUMA1, SFPQ, SND1, SPEN, U2AF1, DDX5 |
| diffuse gastric adenocarcinoma | 12/24 | 0.034851 | 1.63x | PSIP1, PABPC1, FUBP1, DDX6, HNRNPA2B1, SRSF3, SF3B1, RNF213, QKI, SPEN, RBM10, THRAP3 |
| esophageal carcinoma | 12/24 | 0.034851 | 1.63x | PSIP1, HNRNPA2B1, DDX3X, SF3B1, NUMA1, RNF213, EWSR1, SND1, SPEN, RBM10, A1CF, DDX5 |
| HER2 Positive Breast Carcinoma | 18/40 | 0.035407 | 1.46x | PSIP1, PABPC1, DDX6, PCBP1, DDX3X, HNRNPA2B1, SF3B1, NUMA1, ZCCHC8, SFPQ, RNF213, EWSR1, QKI, SND1, SPEN, RBM10, A1CF, THRAP3 |
| Burkitts lymphoma | 10/19 | 0.036034 | 1.71x | THRAP3, FUBP1, DDX3X, HNRNPA2B1, EWSR1, QKI, SND1, SPEN, A1CF, PCBP1 |
| Uterine Carcinosarcoma | 19/43 | 0.037925 | 1.44x | PSIP1, NONO, SRSF3, FUBP1, SF3B1, ZCCHC8, QKI, SPEN, DDX6, NUMA1, RNF213, EWSR1, THRAP3, DDX3X, SFPQ, U2AF1, SND1, RBM10, A1CF |
| Gallbladder Adenocarcinoma | 17/38 | 0.043102 | 1.46x | PSIP1, NONO, PABPC1, FUBP1, DDX3X, DDX6, HNRNPA2B1, SF3B1, NUMA1, RNF213, SFPQ, SND1, SPEN, RBM10, U2AF1, THRAP3, DDX5 |
| thyroid cancer | 9/17 | 0.044464 | 1.72x | CELF2, SAMD4A, SNRPG, HNRNPA3, RBPMS, SNRNP48, BUD13, RBM33, FUBP3 |
| lung carcinoma | 23/55 | 0.045929 | 1.36x | PSIP1, NONO, HNRNPA2B1, SRSF3, DDX5, PABPC1, FUBP1, SF3B1, ZCCHC8, QKI, SPEN, DDX6, NUMA1, RNF213, EWSR1, THRAP3, DDX3X, RALY, SFPQ, U2AF1 |
| cecum adenocarcinoma | 23/55 | 0.045929 | 1.36x | PSIP1, NONO, HNRNPA2B1, SRSF3, DDX5, PABPC1, FUBP1, SF3B1, ZCCHC8, QKI, SPEN, DDX6, NUMA1, RNF213, EWSR1, THRAP3, DDX3X, SFPQ, U2AF1, SND1 |
| oral cavity carcinoma | 18/41 | 0.046005 | 1.43x | PSIP1, NONO, PABPC1, FUBP1, DDX6, DDX3X, SRSF3, SF3B1, NUMA1, RNF213, EWSR1, QKI, A1CF, SND1, SPEN, RBM10, U2AF1, THRAP3 |
| non-small cell lung carcinoma | 24/58 | 0.047476 | 1.35x | PSIP1, NONO, YBX1, HNRNPA2B1, SRSF3, AGO2, DDX5, FUBP1, SF3B1, ZCCHC8, QKI, SPEN, DDX6, NUMA1, RNF213, EWSR1, RBM5, THRAP3, DDX3X, SFPQ |
| extranodal nasal NK/T cell lymphoma | 12/25 | 0.049168 | 1.56x | PSIP1, FUBP1, HNRNPA2B1, DDX3X, SF3B1, NUMA1, RNF213, EWSR1, QKI, SND1, SPEN, A1CF |
💡 说明：
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集