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🔬 剪接因子 HNRNPL 靶基因疾病富集分析
| 疾病名称 | Overlap | P-value | 富集倍数 | 相关靶基因 |
|---|---|---|---|---|
| pulmonary large cell neuroendocrine carcinoma | 13/23 | 0.007967 | 1.84x | ZCCHC8, SF3B1, THRAP3, DDX5, SFPQ, RBM10, HNRNPA2B1, PSIP1, RNF213, FUBP1, DDX3X, SND1, QKI |
| coronary atherosclerosis | 6/8 | 0.012346 | 2.44x | SF3A3, ADAR, CPEB4, AGO2, CCNL1, BUD13 |
| Duodenal Adenocarcinoma | 20/43 | 0.017877 | 1.51x | SF3B1, THRAP3, SFPQ, RNF213, A1CF, EWSR1, HNRNPA2B1, QKI, ZCCHC8, NUMA1, U2AF1, PSIP1, FUBP1, NONO, DDX5, SPEN, RBM10, DDX6, DDX3X, SND1 |
| Ampulla of Vater Carcinoma | 11/20 | 0.018981 | 1.79x | ZCCHC8, SF3B1, U2AF1, SPEN, THRAP3, RBM10, HNRNPA2B1, PSIP1, RNF213, FUBP1, SND1 |
| response to stimulus | 6/9 | 0.027608 | 2.17x | PTBP2, ZRANB2, CWC27, CWC22, KHDRBS3, BUD13 |
| skin angiosarcoma | 3/3 | 0.028722 | 3.25x | SND1, DDX3X, RNF213 |
| gastric ulcer | 3/3 | 0.028722 | 3.25x | RBM33, HNRNPLL, SND1 |
| skin carcinoma | 19/42 | 0.029066 | 1.47x | SF3B1, THRAP3, RNF213, A1CF, PABPC1, EWSR1, HNRNPA2B1, QKI, ZCCHC8, NUMA1, U2AF1, RALY, PSIP1, SPEN, RBM10, SRSF3, DDX6, DDX3X, SND1 |
| small intestinal neuroendocrine tumor G1 | 5/7 | 0.031214 | 2.32x | U2AF1, RBM10, PSIP1, RNF213, DDX6 |
| superficial spreading melanoma | 20/45 | 0.031233 | 1.45x | SF3B1, THRAP3, RNF213, PCBP1, A1CF, EWSR1, HNRNPA2B1, QKI, NUMA1, U2AF1, PSIP1, FUBP1, NONO, DDX5, SPEN, RBM10, SRSF3, DDX6, DDX3X, SND1 |
| oral squamous cell carcinoma | 17/37 | 0.032659 | 1.49x | ZCCHC8, SF3B1, NUMA1, FUBP1, THRAP3, SPEN, EWSR1, DDX5, RBM10, HNRNPA2B1, RNF213, QKI, NONO, DDX6, DDX3X, SND1, PABPC1 |
| esophageal carcinoma | 12/24 | 0.034851 | 1.63x | NUMA1, SF3B1, DDX5, SPEN, EWSR1, RBM10, HNRNPA2B1, PSIP1, RNF213, A1CF, DDX3X, SND1 |
| salivary gland adenoid cystic carcinoma | 12/24 | 0.034851 | 1.63x | NUMA1, SF3B1, NONO, U2AF1, SPEN, SFPQ, DDX5, HNRNPA2B1, FUBP1, DDX6, DDX3X, SND1 |
| diffuse gastric adenocarcinoma | 12/24 | 0.034851 | 1.63x | SF3B1, THRAP3, SPEN, RBM10, HNRNPA2B1, PSIP1, RNF213, QKI, SRSF3, FUBP1, DDX6, PABPC1 |
| HER2 Positive Breast Carcinoma | 18/40 | 0.035407 | 1.46x | ZCCHC8, SF3B1, NUMA1, THRAP3, SPEN, EWSR1, SFPQ, RBM10, HNRNPA2B1, DDX6, PSIP1, RNF213, QKI, PCBP1, A1CF, DDX3X, SND1, PABPC1 |
| Burkitts lymphoma | 10/19 | 0.036034 | 1.71x | FUBP1, THRAP3, SPEN, EWSR1, HNRNPA2B1, PCBP1, A1CF, DDX3X, SND1, QKI |
| Uterine Carcinosarcoma | 19/43 | 0.037925 | 1.44x | SF3B1, THRAP3, SFPQ, RNF213, A1CF, EWSR1, QKI, ZCCHC8, NUMA1, U2AF1, PSIP1, FUBP1, NONO, SPEN, RBM10, SRSF3, DDX6, DDX3X, SND1 |
| Gallbladder Adenocarcinoma | 17/38 | 0.043102 | 1.46x | NUMA1, SF3B1, FUBP1, U2AF1, SPEN, THRAP3, SFPQ, RBM10, DDX5, HNRNPA2B1, PSIP1, RNF213, NONO, DDX6, DDX3X, SND1, PABPC1 |
| thyroid cancer | 9/17 | 0.044464 | 1.72x | RBM33, CELF2, HNRNPA3, SNRNP48, FUBP3, SNRPG, SAMD4A, BUD13, RBPMS |
| lung carcinoma | 23/55 | 0.045929 | 1.36x | SF3B1, THRAP3, SFPQ, RNF213, A1CF, PABPC1, EWSR1, HNRNPA2B1, QKI, ZCCHC8, NUMA1, U2AF1, RALY, PSIP1, FUBP1, NONO, DDX5, SPEN, RBM10, SRSF3 |
| cecum adenocarcinoma | 23/55 | 0.045929 | 1.36x | SF3B1, THRAP3, SFPQ, RNF213, PCBP1, A1CF, PABPC1, EWSR1, HNRNPA2B1, QKI, ZCCHC8, NUMA1, U2AF1, PSIP1, FUBP1, NONO, DDX5, SPEN, RBM10, SRSF3 |
| oral cavity carcinoma | 18/41 | 0.046005 | 1.43x | NUMA1, SF3B1, FUBP1, U2AF1, SPEN, EWSR1, THRAP3, RBM10, DDX6, PSIP1, RNF213, QKI, SRSF3, NONO, A1CF, DDX3X, SND1, PABPC1 |
| non-small cell lung carcinoma | 24/58 | 0.047476 | 1.35x | SF3B1, THRAP3, SFPQ, RNF213, A1CF, EWSR1, HNRNPA2B1, YBX1, QKI, ZCCHC8, NUMA1, RBM5, U2AF1, PSIP1, NONO, FUBP1, AGO2, DDX5, SPEN, RBM10 |
| extranodal nasal NK/T cell lymphoma | 12/25 | 0.049168 | 1.56x | NUMA1, SF3B1, SPEN, EWSR1, HNRNPA2B1, PSIP1, RNF213, FUBP1, A1CF, DDX3X, SND1, QKI |
💡 说明：
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集