🔬 剪接因子 HNRNPU 靶基因疾病富集分析

疾病名称	Overlap	P-value	富集倍数	相关靶基因
autism	7/9	0.013521	2.14x	THOC2, NONO, FMR1, SNRPN, PPIL2, DHX30, XRN2
breast carcinoma	31/63	0.019180	1.35x	PSIP1, CPEB3, NONO, HNRNPA2B1, PRCC, SRSF3, CRNKL1, RBM15, FAM50A, DDX5, PABPC1, FUBP1, SF3B1, ZCCHC8, QKI, SPEN, DDX6, NUMA1, EWSR1, THRAP3
HIV infection	5/6	0.025975	2.29x	PSIP1, NCBP1, POLR2G, NCBP2, TAF15
neurodegenerative disease	165/422	0.026750	1.08x	PSIP1, CHERP, CDC5L, SRSF3, MATR3, HNRNPF, SART3, SAFB2, DBR1, RBM39, SRRM1, THOC5, RBM4, RBM27, RBMX, DDX6, PRPF19, ZRANB2, SNRPE, TRA2A
coronary atherosclerosis	6/8	0.029914	2.06x	AGO2, SF3A3, CCNL1, BUD13, ADAR, CPEB4
gastric ulcer	3/3	0.047634	2.75x	SND1, RBM33, HNRNPLL
acrocephalosyndactyly	3/3	0.047634	2.75x	NCBP1, POLR2G, NCBP2

💡 说明：
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集