🔬 剪接因子 HNRNPU 靶基因疾病富集分析

疾病名称	Overlap	P-value	富集倍数	相关靶基因
autism	7/9	0.013521	2.14x	DHX30, PPIL2, SNRPN, THOC2, NONO, FMR1, XRN2
breast carcinoma	31/63	0.019180	1.35x	FUS, SF3B1, THRAP3, SFPQ, PABPC1, CRNKL1, EWSR1, ADAR, HNRNPA2B1, RBM15, QKI, FAM50A, ZCCHC8, NUMA1, U2AF1, RALY, PSIP1, NONO, FUBP1, CPEB3
HIV infection	5/6	0.025975	2.29x	POLR2G, NCBP1, TAF15, PSIP1, NCBP2
neurodegenerative disease	165/422	0.026750	1.08x	SF3B1, SRSF1, RBM38, SAMD4B, HNRNPK, MAGOH, RBM17, PRPF19, DDX17, PABPC1, RBPMS, MBNL1, BUD13, DHX30, LUC7L3, SART3, CTNNBL1, EIF4B, DHX35, SYF2
coronary atherosclerosis	6/8	0.029914	2.06x	SF3A3, ADAR, CPEB4, AGO2, CCNL1, BUD13
acrocephalosyndactyly	3/3	0.047634	2.75x	NCBP2, POLR2G, NCBP1
gastric ulcer	3/3	0.047634	2.75x	RBM33, HNRNPLL, SND1

💡 说明：
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集