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🔬 剪接因子 HNRNPUL1 靶基因疾病富集分析
| 疾病名称 | Overlap | P-value | 富集倍数 | 相关靶基因 |
|---|---|---|---|---|
| gastric intestinal type adenocarcinoma | 12/41 | 0.015012 | 1.9x | FUS, SRSF2, PABPC1, DDX5, THRAP3, EWSR1, HNRNPA2B1, RNF213, FUBP1, A1CF, SND1, QKI |
| metaplastic breast carcinoma | 8/23 | 0.016130 | 2.25x | FUS, SRSF2, PABPC1, DDX5, THRAP3, A1CF, SND1, QKI |
| pulmonary large cell neuroendocrine carcinoma | 8/23 | 0.016130 | 2.25x | DDX5, THRAP3, SFPQ, HNRNPA2B1, RNF213, FUBP1, SND1, QKI |
| Olfactory Neuroblastoma | 5/11 | 0.017018 | 2.94x | DDX5, EWSR1, SFPQ, HNRNPA2B1, SND1 |
| Burkitts lymphoma | 7/19 | 0.017423 | 2.39x | THRAP3, EWSR1, HNRNPA2B1, FUBP1, A1CF, SND1, QKI |
| type 2 diabetes mellitus | 16/63 | 0.021303 | 1.64x | RNF34, RBM6, IGF2BP3, THRAP3, SREK1, HNRNPK, SRRM2, RALY, PABPC4, A1CF, CCNL1, CELF1, RBMS1, SND1, QKI, MBNL1 |
| T-cell large granular lymphocyte leukemia | 4/8 | 0.022831 | 3.24x | EWSR1, SFPQ, SND1, HNRNPA2B1 |
| combined hepatocellular carcinoma and cholangiocarcinoma | 7/20 | 0.023457 | 2.27x | SRSF2, DDX5, EWSR1, SFPQ, FUBP1, SND1, QKI |
| acral lentiginous melanoma | 6/16 | 0.025242 | 2.43x | SRSF2, PABPC1, EWSR1, FUBP1, SND1, QKI |
| meningioma | 5/12 | 0.025647 | 2.7x | FUS, EWSR1, SFPQ, RNF213, FUBP1 |
| kidney neoplasm | 13/49 | 0.026475 | 1.72x | FUS, SRSF2, PABPC1, DDX5, THRAP3, EWSR1, SFPQ, HNRNPA2B1, RNF213, FUBP1, A1CF, SND1, QKI |
| extranodal nasal NK/T cell lymphoma | 8/25 | 0.027176 | 2.07x | FUS, EWSR1, HNRNPA2B1, RNF213, FUBP1, A1CF, SND1, QKI |
| lung carcinoma | 14/55 | 0.030506 | 1.65x | FUS, SRSF2, PABPC1, DDX5, THRAP3, EWSR1, SFPQ, HNRNPA2B1, RALY, RNF213, FUBP1, A1CF, SND1, QKI |
| central nervous system primitive neuroectodermal neoplasm | 13/50 | 0.031174 | 1.68x | FUS, SRSF2, PABPC1, DDX5, THRAP3, EWSR1, SFPQ, HNRNPA2B1, RNF213, FUBP1, A1CF, SND1, QKI |
| Rectal Tubular Adenoma | 5/13 | 0.036655 | 2.49x | SRSF2, EWSR1, RNF213, SND1, QKI |
| diffuse large B-cell lymphoma | 11/42 | 0.044360 | 1.7x | SRSF2, RBM38, PABPC1, DDX5, EWSR1, HNRNPA2B1, RNF213, FUBP1, A1CF, SND1, QKI |
| breast carcinoma | 15/63 | 0.044926 | 1.54x | FUS, SRSF2, PABPC1, DDX5, THRAP3, EWSR1, SFPQ, ZC3H11A, HNRNPA2B1, RALY, RNF213, FUBP1, A1CF, SND1, QKI |
| brain glioblastoma | 13/53 | 0.048909 | 1.59x | FUS, SRSF2, PABPC1, DDX5, THRAP3, EWSR1, SFPQ, HNRNPA2B1, RNF213, FUBP1, A1CF, SND1, QKI |
| Gastric Neuroendocrine Tumor G1 | 7/23 | 0.049805 | 1.97x | FUS, THRAP3, EWSR1, SFPQ, HNRNPA2B1, RNF213, FUBP1 |
💡 说明：
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集