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🔬 剪接因子 KHSRP 靶基因疾病富集分析

疾病名称	Overlap	P-value	富集倍数	相关靶基因
hepatocellular carcinoma	54/113	0.014513	1.25x	PSIP1, NONO, CDC5L, YBX1, HNRNPA2B1, SRSF3, SRSF2, CRNKL1, AGO2, RBM15, TARDBP, DDX5, KHDRBS1, PABPC1, ZC3H13, FUBP1, SF3B1, ZCCHC8, CPSF6, QKI
hemorrhoid	4/4	0.021019	2.62x	SND1, CCAR2, SFMBT1, CCNL1
Duodenal Adenocarcinoma	23/43	0.025636	1.4x	PSIP1, NONO, HNRNPA2B1, CRNKL1, DDX5, FUBP1, SF3B1, ZCCHC8, QKI, SPEN, DDX6, NUMA1, RNF213, EWSR1, ZMYM3, THRAP3, FUS, DDX3X, SFPQ, U2AF1
esophageal carcinoma	14/24	0.033605	1.53x	PSIP1, FUS, DDX3X, HNRNPA2B1, SF3B1, NUMA1, RNF213, EWSR1, SND1, SPEN, ZMYM3, RBM10, A1CF, DDX5
salivary gland adenoid cystic carcinoma	14/24	0.033605	1.53x	NONO, FUBP1, DDX6, DDX3X, HNRNPA2B1, SF3B1, CRNKL1, NUMA1, SFPQ, SND1, SPEN, ZMYM3, U2AF1, DDX5
brain glioblastoma	27/53	0.033938	1.33x	PSIP1, NONO, HNRNPA2B1, SRSF3, SRSF2, CRNKL1, RBM15, DDX5, PABPC1, FUBP1, SF3B1, ZCCHC8, QKI, SPEN, DDX6, NUMA1, RNF213, EWSR1, A1CF, ZMYM3
Ampulla of Vater Carcinoma	12/20	0.037481	1.57x	PSIP1, FUBP1, HNRNPA2B1, SF3B1, ZCCHC8, RNF213, SND1, SPEN, ZMYM3, RBM10, U2AF1, THRAP3
multiple myeloma	25/49	0.040049	1.33x	PSIP1, NONO, HNRNPA2B1, SRSF2, CRNKL1, RBM15, DDX5, PABPC1, FUBP1, SF3B1, QKI, SPEN, EFTUD2, DDX6, NUMA1, RNF213, EWSR1, A1CF, ZMYM3, THRAP3
Merkel cell skin cancer	17/31	0.040585	1.43x	FUS, FUBP1, DDX6, DDX3X, SF3B1, ZCCHC8, CRNKL1, RNF213, SFPQ, EWSR1, QKI, A1CF, SND1, SPEN, ZMYM3, RBM10, U2AF1
gastric carcinoma	28/56	0.040884	1.31x	PSIP1, NONO, HNRNPA2B1, SRSF3, SRSF2, CRNKL1, RBM15, DDX5, PABPC1, FUBP1, SF3B1, ZCCHC8, QKI, SPEN, DDX6, NUMA1, RNF213, EWSR1, A1CF, ZMYM3
medulloblastoma	7/10	0.041447	1.83x	CCAR1, NONO, DDX6, SF3B1, DDX3X, RNF213, ZMYM3
soft tissue sarcoma	24/47	0.043502	1.34x	PSIP1, NONO, HNRNPA2B1, SRSF3, SRSF2, CRNKL1, RBM15, DDX5, SF3B1, ZCCHC8, QKI, SPEN, DDX6, NUMA1, RNF213, EWSR1, A1CF, ZMYM3, FUS, DDX3X
nodular melanoma	24/47	0.043502	1.34x	PSIP1, NONO, HNRNPA2B1, SRSF3, SRSF2, CRNKL1, RBM15, DDX5, FUBP1, SF3B1, ZCCHC8, QKI, SPEN, NUMA1, RNF213, EWSR1, A1CF, ZMYM3, THRAP3, FUS
superficial spreading melanoma	23/45	0.047252	1.34x	PSIP1, NONO, HNRNPA2B1, SRSF3, CRNKL1, RBM15, DDX5, FUBP1, SF3B1, QKI, SPEN, DDX6, NUMA1, RNF213, EWSR1, ZMYM3, THRAP3, DDX3X, U2AF1, SND1
bile duct adenocarcinoma	23/45	0.047252	1.34x	PSIP1, NONO, HNRNPA2B1, SRSF3, CRNKL1, RBM15, DDX5, PABPC1, FUBP1, SF3B1, QKI, SPEN, DDX6, NUMA1, RNF213, EWSR1, ZMYM3, FUS, DDX3X, SFPQ

💡 说明：
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集