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🔬 剪接因子 KHSRP 靶基因疾病富集分析

疾病名称	Overlap	P-value	富集倍数	相关靶基因
hepatocellular carcinoma	54/113	0.014513	1.25x	FUS, SF3B1, SRSF1, THRAP3, SFPQ, KHDRBS1, HNRNPK, RNF213, PCBP1, A1CF, PRPF19, DDX17, PABPC1, EIF4A3, SRSF10, ELAVL1, CRNKL1, EWSR1, ADAR, CPSF6
hemorrhoid	4/4	0.021019	2.62x	SFMBT1, CCNL1, CCAR2, SND1
Duodenal Adenocarcinoma	23/43	0.025636	1.4x	FUS, SF3B1, THRAP3, SFPQ, RNF213, A1CF, CRNKL1, EWSR1, HNRNPA2B1, QKI, ZCCHC8, NUMA1, U2AF1, PSIP1, ZMYM3, FUBP1, NONO, DDX5, SPEN, RBM10
esophageal carcinoma	14/24	0.033605	1.53x	NUMA1, FUS, SF3B1, DDX5, SPEN, EWSR1, RBM10, HNRNPA2B1, PSIP1, ZMYM3, RNF213, A1CF, DDX3X, SND1
salivary gland adenoid cystic carcinoma	14/24	0.033605	1.53x	NUMA1, SF3B1, FUBP1, CRNKL1, SPEN, U2AF1, SFPQ, DDX5, HNRNPA2B1, ZMYM3, NONO, DDX6, DDX3X, SND1
brain glioblastoma	27/53	0.033938	1.33x	FUS, SF3B1, THRAP3, SFPQ, RNF213, A1CF, PABPC1, CRNKL1, EWSR1, HNRNPA2B1, RBM15, QKI, ZCCHC8, NUMA1, U2AF1, PSIP1, ZMYM3, NONO, FUBP1, SRSF2
Ampulla of Vater Carcinoma	12/20	0.037481	1.57x	ZCCHC8, SF3B1, U2AF1, SPEN, THRAP3, RBM10, HNRNPA2B1, PSIP1, ZMYM3, RNF213, FUBP1, SND1
multiple myeloma	25/49	0.040049	1.33x	FUS, SF3B1, THRAP3, RNF213, A1CF, PABPC1, CRNKL1, EWSR1, HNRNPA2B1, RBM15, QKI, NUMA1, U2AF1, PSIP1, ZMYM3, NONO, FUBP1, EFTUD2, SRSF2, DDX5
Merkel cell skin cancer	17/31	0.040585	1.43x	ZCCHC8, FUS, SF3B1, CRNKL1, SPEN, EWSR1, U2AF1, RBM10, SFPQ, DDX6, ZMYM3, RNF213, FUBP1, A1CF, DDX3X, SND1, QKI
gastric carcinoma	28/56	0.040884	1.31x	FUS, SF3B1, THRAP3, SFPQ, RNF213, A1CF, PABPC1, CRNKL1, EWSR1, HNRNPA2B1, RBM15, QKI, ZCCHC8, NUMA1, U2AF1, PSIP1, ZMYM3, NONO, FUBP1, DDX19A
medulloblastoma	7/10	0.041447	1.83x	SF3B1, ZMYM3, RNF213, NONO, DDX6, CCAR1, DDX3X
nodular melanoma	24/47	0.043502	1.34x	FUS, SF3B1, THRAP3, RNF213, A1CF, CRNKL1, EWSR1, HNRNPA2B1, RBM15, QKI, ZCCHC8, NUMA1, U2AF1, PSIP1, ZMYM3, NONO, FUBP1, SRSF2, DDX5, SPEN
soft tissue sarcoma	24/47	0.043502	1.34x	FUS, SF3B1, SFPQ, RNF213, A1CF, CRNKL1, EWSR1, HNRNPA2B1, RBM15, QKI, ZCCHC8, NUMA1, U2AF1, PSIP1, ZMYM3, NONO, SRSF2, DDX5, SPEN, RBM10
superficial spreading melanoma	23/45	0.047252	1.34x	SF3B1, THRAP3, RNF213, PCBP1, A1CF, CRNKL1, EWSR1, HNRNPA2B1, RBM15, QKI, NUMA1, U2AF1, PSIP1, ZMYM3, NONO, FUBP1, DDX5, SPEN, RBM10, SRSF3
bile duct adenocarcinoma	23/45	0.047252	1.34x	FUS, SF3B1, SFPQ, RNF213, PABPC1, CRNKL1, EWSR1, HNRNPA2B1, RBM15, QKI, NUMA1, U2AF1, PSIP1, ZMYM3, NONO, FUBP1, DDX5, SPEN, RBM10, SRSF3

💡 说明：
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集