🔬 剪接因子 MATR3 靶基因疾病富集分析

疾病名称	Overlap	P-value	富集倍数	相关靶基因
gastric ulcer	3/3	0.002970	6.89x	RBM33, HNRNPLL, SND1
autism	5/9	0.004527	3.83x	DHX30, PPIL2, THOC2, FMR1, XRN2
type 2 diabetes mellitus	17/63	0.004671	1.86x	RBM6, IGF2BP3, THRAP3, SREK1, SRRM2, CELF1, LSM5, RALY, FMR1, TRA2B, PRPF40A, SF3B4, CCDC12, RBMS1, SND1, QKI, MBNL1
hearing loss	4/6	0.004961	4.59x	RBPMS, ZFR, QKI, AGO2
alcohol drinking	14/49	0.006022	1.97x	PTBP2, MBNL2, DDX23, IGF2BP3, ZRANB2, AKAP1, ADAR, SREK1, DHX35, CTNNBL1, DDX18, SND1, QKI, MBNL1
intelligence	11/39	0.016646	1.94x	PTBP2, SF3B1, RBM6, DHX30, ZNF326, ZNF638, STAU1, LSM5, CWC22, RBMS1, SND1
Abruptio Placentae	11/40	0.020210	1.9x	SFSWAP, DDX23, IGF2BP3, PPIH, ZFR, LSM5, CWC22, CNOT4, PTBP3, DDX18, QKI
self-injurious ideation	2/2	0.020856	6.89x	CWC22, EFTUD2
myxedema	2/2	0.020856	6.89x	SRRT, AGO2
Sensorineural hearing impairment	3/5	0.023768	4.14x	ZFR, QKI, RBPMS
atrial fibrillation	12/47	0.027691	1.76x	PTBP2, SF3B1, RBM20, MBNL2, ZNF638, AGO2, HNRNPF, ZNF131, XRN2, SAMD4A, RBMS1, RBPMS
injury	5/13	0.028548	2.65x	PTBP2, THRAP3, SGMS1, LSM5, DDX18
secondary malignant neoplasm	3/6	0.042575	3.45x	DHX35, CASC3, LSM3
hypertension	11/45	0.046942	1.68x	MBNL2, RBM26, AGO2, CPSF6, STAU1, PSPC1, EIF4B, PRPF40A, ZNF131, CELF1, RBMS1
cancer	14/62	0.048961	1.56x	SF3B1, PTBP1, IGF2BP3, ZC3HAV1, ADAR, RBM10, CPSF6, HNRNPA2B1, RALY, SRSF3, AGO2, RBMS1, SND1, QKI

💡 说明：
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集