🔬 剪接因子 MATR3 靶基因疾病富集分析

疾病名称	Overlap	P-value	富集倍数	相关靶基因
gastric ulcer	3/3	0.002970	6.89x	RBM33, HNRNPLL, SND1
autism	5/9	0.004527	3.83x	THOC2, FMR1, PPIL2, DHX30, XRN2
type 2 diabetes mellitus	17/63	0.004671	1.86x	CCDC12, RBMS1, SF3B4, FMR1, CELF1, RALY, SREK1, SRRM2, TRA2B, MBNL1, PRPF40A, QKI, SND1, LSM5, RBM6, IGF2BP3, THRAP3
hearing loss	4/6	0.004961	4.59x	QKI, ZFR, RBPMS, AGO2
alcohol drinking	14/49	0.006022	1.97x	PTBP2, SREK1, CTNNBL1, ZRANB2, DHX35, MBNL1, ADAR, DDX18, MBNL2, QKI, AKAP1, DDX23, IGF2BP3, SND1
intelligence	11/39	0.016646	1.94x	RBMS1, ZNF638, CWC22, PTBP2, SF3B1, ZNF326, SND1, RBM6, LSM5, DHX30, STAU1
Abruptio Placentae	11/40	0.020210	1.9x	CWC22, PTBP3, QKI, DDX18, ZFR, LSM5, CNOT4, DDX23, PPIH, SFSWAP, IGF2BP3
myxedema	2/2	0.020856	6.89x	SRRT, AGO2
self-injurious ideation	2/2	0.020856	6.89x	CWC22, EFTUD2
Sensorineural hearing impairment	3/5	0.023768	4.14x	QKI, ZFR, RBPMS
atrial fibrillation	12/47	0.027691	1.76x	SAMD4A, ZNF638, ZNF131, PTBP2, SF3B1, AGO2, RBPMS, HNRNPF, RBM20, MBNL2, RBMS1, XRN2
injury	5/13	0.028548	2.65x	PTBP2, DDX18, SGMS1, LSM5, THRAP3
secondary malignant neoplasm	3/6	0.042575	3.45x	LSM3, DHX35, CASC3
hypertension	11/45	0.046942	1.68x	RBMS1, ZNF131, PSPC1, EIF4B, AGO2, CPSF6, PRPF40A, MBNL2, CELF1, STAU1, RBM26
cancer	14/62	0.048961	1.56x	ZC3HAV1, HNRNPA2B1, SF3B1, SRSF3, RALY, AGO2, CPSF6, QKI, ADAR, SND1, RBMS1, RBM10, IGF2BP3, PTBP1

💡 说明：
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集