🔬 剪接因子 MBNL1 靶基因疾病富集分析

疾病名称	Overlap	P-value	富集倍数	相关靶基因
neurodegenerative disease	154/422	0.006462	1.1x	SF3B1, SRSF1, DHX38, SAMD4B, HNRNPK, PRPF38A, RBM17, RBMX2, PRPF19, DDX17, PABPC1, RBPMS, MBNL1, BUD13, DHX30, SART3, CTNNBL1, EIF4B, DHX35, LSM4
angina pectoris	4/4	0.011739	3.02x	SF3A3, RNF213, DHX38, BUD13
skin angiosarcoma	3/3	0.035834	3.02x	SND1, DDX3X, RNF213
gastric ulcer	3/3	0.035834	3.02x	RBM33, HNRNPLL, SND1
Gallbladder Adenocarcinoma	18/38	0.042172	1.43x	NUMA1, FUS, SF3B1, ZRSR2, FUBP1, PABPC1, THRAP3, SPEN, SFPQ, DDX5, RBM10, HNRNPA2B1, ZMYM3, RNF213, NONO, DDX3X, SND1, PRCC
pulmonary large cell neuroendocrine carcinoma	12/23	0.042401	1.58x	SF3B1, ZRSR2, THRAP3, DDX5, SFPQ, RBM10, HNRNPA2B1, RNF213, FUBP1, DDX3X, SND1, QKI
gastric intestinal type adenocarcinoma	19/41	0.047373	1.4x	FUS, ZRSR2, THRAP3, RNF213, PABPC1, HNRNPA2B1, RBM15, QKI, NUMA1, ZMYM3, NONO, FUBP1, SRSF2, DDX5, SPEN, RBM10, DDX3X, SND1, PRCC

💡 说明：
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集