🔬 剪接因子 MBNL1 靶基因疾病富集分析

疾病名称	Overlap	P-value	富集倍数	相关靶基因
neurodegenerative disease	154/422	0.006462	1.1x	CHERP, SRSF3, MATR3, HNRNPF, SART3, SAFB2, SF3A1, RNF20, RBM39, RBM4, THOC5, NXF1, RBM27, DHX38, PRPF19, ZRANB2, SNRPE, TRA2A, ZMAT5, RBM19
angina pectoris	4/4	0.011739	3.02x	BUD13, DHX38, SF3A3, RNF213
gastric ulcer	3/3	0.035834	3.02x	SND1, RBM33, HNRNPLL
skin angiosarcoma	3/3	0.035834	3.02x	DDX3X, SND1, RNF213
Gallbladder Adenocarcinoma	18/38	0.042172	1.43x	NONO, FUS, PABPC1, FUBP1, DDX3X, PRCC, HNRNPA2B1, SF3B1, NUMA1, RNF213, SFPQ, SND1, SPEN, ZMYM3, RBM10, ZRSR2, THRAP3, DDX5
pulmonary large cell neuroendocrine carcinoma	12/23	0.042401	1.58x	FUBP1, DDX3X, HNRNPA2B1, SF3B1, RNF213, SFPQ, QKI, SND1, RBM10, ZRSR2, THRAP3, DDX5
gastric intestinal type adenocarcinoma	19/41	0.047373	1.4x	NONO, HNRNPA2B1, PRCC, RBM15, DDX5, PABPC1, FUBP1, QKI, SPEN, ZRSR2, NUMA1, RNF213, ZMYM3, THRAP3, FUS, DDX3X, SND1, RBM10, SRSF2

💡 说明：
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集