🔬 剪接因子 MSI1 靶基因疾病富集分析

疾病名称	Overlap	P-value	富集倍数	相关靶基因
neoplasm	43/117	0.008676	1.35x	RBM38, HNRNPA2B1, AGO2, G3BP1, RBM15, DDX5, KHDRBS1, FUBP1, SF3B1, DKC1, KRR1, QKI, SPEN, NXF1, MSI1, HNRNPC, PTBP1, RBMS3, FMR1, UPF1
gastric ulcer	3/3	0.020095	3.66x	SND1, RBM33, HNRNPLL
skin angiosarcoma	3/3	0.020095	3.66x	DDX3X, SND1, RNF213
pulmonary large cell neuroendocrine carcinoma	11/23	0.026104	1.75x	FUBP1, DDX3X, HNRNPA2B1, SF3B1, RNF213, SFPQ, QKI, SND1, RBM10, THRAP3, DDX5
cancer	24/62	0.026836	1.42x	HNRNPA2B1, AGO2, RBM15, DDX5, KHDRBS1, SNW1, SF3B1, CPSF6, QKI, HNRNPC, PTBP1, RNF213, ELAVL1, IGF2BP3, CCAR2, SRSF1, ZC3HAV1, HNRNPA1, DDX3X, RALY
Atypical Meningioma	9/19	0.046444	1.74x	FUS, PABPC1, FUBP1, DDX3X, SF3B1, RNF213, SND1, RBM10, DDX5

💡 说明：
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集