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🔬 剪接因子 NOVA1 靶基因疾病富集分析
| 疾病名称 | Overlap | P-value | 富集倍数 | 相关靶基因 |
|---|---|---|---|---|
| Gastric Adenoma | 9/24 | 0.001697 | 2.9x | NUMA1, SPEN, SFPQ, ZMYM3, RNF213, DDX6, SND1, QKI, CPEB3 |
| hearing loss | 4/6 | 0.003211 | 5.15x | RBPMS, ZFR, QKI, AGO2 |
| salivary gland adenoid cystic carcinoma | 8/24 | 0.007252 | 2.57x | NUMA1, SPEN, SFPQ, HNRNPA2B1, ZMYM3, NONO, DDX6, SND1 |
| gliomatosis cerebri | 6/15 | 0.007515 | 3.09x | NUMA1, SPEN, HNRNPA2B1, RNF213, SND1, CPEB3 |
| pancreatic neuroendocrine tumor | 10/35 | 0.009140 | 2.21x | NUMA1, SPEN, SFPQ, HNRNPA2B1, ZMYM3, RNF213, DDX6, SND1, QKI, CPEB3 |
| T-cell large granular lymphocyte leukemia | 4/8 | 0.012181 | 3.86x | DDX6, SFPQ, SND1, HNRNPA2B1 |
| sialolithiasis | 4/8 | 0.012181 | 3.86x | PTBP2, RBM47, RBMS3, QKI |
| Placental Choriocarcinoma | 6/17 | 0.014964 | 2.73x | SPEN, SFPQ, ZMYM3, RNF213, DDX6, QKI |
| Duodenal Adenocarcinoma | 11/43 | 0.015200 | 1.98x | NUMA1, SPEN, SFPQ, HNRNPA2B1, ZMYM3, RNF213, NONO, DDX6, SND1, QKI, CPEB3 |
| Gallbladder Adenocarcinoma | 10/38 | 0.016842 | 2.03x | NUMA1, SPEN, SFPQ, HNRNPA2B1, ZMYM3, RNF213, NONO, DDX6, SND1, CPEB3 |
| Sensorineural hearing impairment | 3/5 | 0.017271 | 4.63x | ZFR, QKI, RBPMS |
| Gastric Neuroendocrine Tumor G1 | 7/23 | 0.020457 | 2.35x | NUMA1, SPEN, SFPQ, HNRNPA2B1, ZMYM3, RNF213, CPEB3 |
| Abnormality of the skeletal system | 23/121 | 0.023077 | 1.47x | PTBP2, MBNL2, HNRNPK, CELF4, RNF213, ANKHD1, CPSF6, CTNNBL1, RALYL, CELF1, KHDC4, QKI, RBM6, SF3A2, RBM19, RBMS3, SRSF5, RBFOX3, PRPF6, HNRNPD |
| nasopharyngeal squamous cell carcinoma | 8/29 | 0.024370 | 2.13x | NUMA1, SPEN, SFPQ, HNRNPA2B1, RNF213, DDX6, QKI, CPEB3 |
| laryngeal squamous cell carcinoma | 5/14 | 0.025033 | 2.76x | SPEN, SFPQ, RBM19, RNF213, SND1 |
| B-cell acute lymphoblastic leukemia | 11/46 | 0.025209 | 1.85x | NUMA1, SPEN, SFPQ, HNRNPA2B1, ZMYM3, RNF213, NONO, DDX6, SND1, QKI, CPEB3 |
| non-small cell lung carcinoma | 13/58 | 0.025740 | 1.73x | NUMA1, NONO, RBM5, YBX1, SPEN, SFPQ, HNRNPA2B1, ZMYM3, RNF213, AGO2, DDX6, SND1, QKI |
| soft tissue sarcoma | 11/47 | 0.029432 | 1.81x | NUMA1, SPEN, SFPQ, HNRNPA2B1, ZMYM3, RNF213, NONO, DDX6, SND1, QKI, CPEB3 |
| renal carcinoma | 4/10 | 0.029755 | 3.09x | SFMBT1, NONO, SFPQ, RBPMS |
| medulloblastoma | 4/10 | 0.029755 | 3.09x | DDX6, ZMYM3, RNF213, NONO |
| neoplasm | 22/117 | 0.029990 | 1.45x | SFPQ, HNRNPK, RNF213, MBNL1, HNRNPA2B1, NXF1, YBX1, QKI, HNRNPC, RBM5, KHSRP, MSI1, RBMS3, AGO2, CPEB3, CELF2, SPEN, PRPF6, G3BP1, SND1 |
| nasopharyngeal carcinoma | 3/6 | 0.031331 | 3.86x | YBX1, G3BP1, HNRNPK |
| Abnormality of limbs | 3/6 | 0.031331 | 3.86x | DDX6, PTBP2, KHDRBS3 |
| colon carcinoma | 3/6 | 0.031331 | 3.86x | SPEN, SND1, HNRNPA2B1 |
| extranodal nasal NK/T cell lymphoma | 7/25 | 0.032251 | 2.16x | NUMA1, SPEN, HNRNPA2B1, RNF213, SND1, QKI, CPEB3 |
| small cell lung carcinoma | 11/48 | 0.034146 | 1.77x | NUMA1, SPEN, SFPQ, HNRNPA2B1, ZMYM3, RNF213, NONO, DDX6, SND1, QKI, CPEB3 |
| papillary renal cell carcinoma | 10/43 | 0.039142 | 1.8x | NUMA1, SPEN, SFPQ, HNRNPA2B1, ZMYM3, RNF213, DDX6, SND1, QKI, CPEB3 |
| Uterine Carcinosarcoma | 10/43 | 0.039142 | 1.8x | NUMA1, SPEN, SFPQ, ZMYM3, RNF213, NONO, DDX6, SND1, QKI, CPEB3 |
| Pancreatic Acinar Cell Carcinoma | 6/21 | 0.042665 | 2.21x | SPEN, HNRNPA2B1, ZMYM3, DDX6, SND1, QKI |
| thyroid neoplasm | 5/16 | 0.044248 | 2.41x | SPEN, HNRNPA2B1, RNF213, SND1, CPEB3 |
💡 说明：
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集