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🔬 剪接因子 NUMA1 靶基因疾病富集分析
| 疾病名称 | Overlap | P-value | 富集倍数 | 相关靶基因 |
|---|---|---|---|---|
| frontotemporal dementia | 3/7 | 0.008713 | 6.24x | HNRNPA2B1, TARDBP, FUS |
| amyotrophic lateral sclerosis | 5/21 | 0.010777 | 3.47x | FUS, HNRNPA1, HNRNPA2B1, MATR3, TARDBP |
| distal myopathy | 2/3 | 0.013230 | 9.71x | HNRNPA1, MATR3 |
| inclusion body myopathy with Paget disease of bone and frontotemporal dementia | 2/4 | 0.025305 | 7.28x | HNRNPA1, HNRNPA2B1 |
| hepatocellular carcinoma | 13/113 | 0.031115 | 1.68x | FUS, PTBP1, PABPC1, HNRNPA1, HNRNPA2B1, DDX17, ZC3H13, NUMA1, SFPQ, TARDBP, HNRNPC, IGF2BP3, HNRNPD |
| frontotemporal dementia with motor neuron disease | 2/5 | 0.040344 | 5.83x | TARDBP, FUS |
| amyotrophic lateral sclerosis, dominant | 2/5 | 0.040344 | 5.83x | TARDBP, FUS |
💡 说明：
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集