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🔬 剪接因子 PABPN1 靶基因疾病富集分析

疾病名称	Overlap	P-value	富集倍数	相关靶基因
dengue disease	18/212	0.002965	1.76x	FUS, PABPC1, YBX1, SF3B1, HNRNPA3, U2AF2, SF3B2, SRSF6, SNRNP200, SRRM2, PABPN1, HNRNPD, SRSF11, RBM5, SRSF5, HNRNPK, SRSF2, SRSF1
genetic disorder	12/113	0.003627	2.2x	NONO, TMEM63A, FUS, DDX6, U2AF2, MATR3, PABPN1, SRRM2, SNRNP200, SF3B2, HNRNPK, SRSF1
Hodgkins lymphoma	6/37	0.006217	3.35x	NONO, FUS, PABPC1, SF3B1, DDX6, SRSF2
medulloblastoma	3/10	0.009775	6.2x	DDX6, SF3B1, NONO
bronchoalveolar adenocarcinoma	4/19	0.010441	4.35x	SF3B1, NONO, FUS, PABPC1
melanoma	7/55	0.012038	2.63x	NONO, FUS, PABPC1, YBX1, SF3B1, DDX6, SRSF2
monoclonal B-cell lymphocytosis	2/4	0.012792	10.34x	DAZAP1, SF3B1
teratoma	2/4	0.012792	10.34x	DDX6, PABPC1
non-small cell lung carcinoma	7/58	0.016063	2.5x	NONO, FUS, YBX1, SF3B1, DDX6, RBM5, SRSF2
leiomyosarcoma	3/12	0.016770	5.17x	DDX6, SRSF2, FUS
myelodysplastic syndrome	4/22	0.017776	3.76x	DDX6, SF3B1, SRSF2, FUS
B-cell acute lymphoblastic leukemia	6/46	0.018288	2.7x	NONO, FUS, PABPC1, SF3B1, DDX6, SRSF2
Endometrial Serous Adenocarcinoma	2/5	0.020679	8.27x	DDX6, FUS
orbit embryonal rhabdomyosarcoma	2/5	0.020679	8.27x	DDX6, SRSF2
pancreatic neoplasm	2/5	0.020679	8.27x	DDX6, SF3B1
anaplastic oligodendroglioma	4/23	0.020793	3.6x	DDX6, SF3B1, SRSF2, PABPC1
papillary thyroid carcinoma	6/48	0.022339	2.58x	NONO, FUS, PABPC1, SF3B1, DDX6, SRSF2
small cell lung carcinoma	6/48	0.022339	2.58x	NONO, FUS, PABPC1, SF3B1, DDX6, SRSF2
multiple myeloma	6/49	0.024579	2.53x	NONO, FUS, PABPC1, SF3B1, DDX6, SRSF2
acute myeloid leukemia	7/63	0.024813	2.3x	NONO, FUS, PABPC1, SF3B1, DDX6, U2AF2, SRSF2
lung adenocarcinoma	7/63	0.024813	2.3x	NONO, FUS, PABPC1, YBX1, SF3B1, DDX6, SRSF2
central nervous system primitive neuroectodermal neoplasm	6/50	0.026969	2.48x	NONO, FUS, PABPC1, SF3B1, DDX6, SRSF2
Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation	6/51	0.029513	2.43x	NONO, FUS, PABPC1, SF3B1, DDX6, SRSF2
Generalized hypotonia	2/6	0.030088	6.89x	DDX6, HNRNPK
nasopharyngeal carcinoma	2/6	0.030088	6.89x	HNRNPK, YBX1
Gallbladder Adenocarcinoma	5/38	0.030487	2.72x	NONO, FUS, PABPC1, DDX6, SF3B1
hepatocellular carcinoma	10/113	0.031789	1.83x	NONO, FUS, PABPC1, YBX1, SF3B1, DDX6, HNRNPD, HNRNPK, SRSF2, SRSF1
ovarian serous adenocarcinoma	6/52	0.032213	2.39x	NONO, FUS, PABPC1, SF3B1, DDX6, SRSF2
brain glioblastoma	6/53	0.035073	2.34x	NONO, FUS, PABPC1, SF3B1, DDX6, SRSF2
Gallbladder Small Cell Neuroendocrine Carcinoma	3/16	0.037400	3.88x	DDX6, SF3B1, FUS

💡 说明：
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集