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🔬 剪接因子 QKI 靶基因疾病富集分析
| 疾病名称 | Overlap | P-value | 富集倍数 | 相关靶基因 |
|---|---|---|---|---|
| thyroid neoplasm | 8/16 | 0.006927 | 2.47x | PSIP1, CPEB3, FUS, PABPC1, HNRNPA2B1, RNF213, SPEN, SND1 |
| Rhabdoid Meningioma | 5/8 | 0.010585 | 3.08x | PSIP1, CPEB3, FUBP1, RNF213, EWSR1 |
| response to xenobiotic stimulus | 6/11 | 0.011787 | 2.69x | PTBP2, CPSF6, PRPF40A, EWSR1, SND1, CPEB4 |
| cancer | 20/62 | 0.013430 | 1.59x | PSIP1, HNRNPA2B1, SRSF3, AGO2, KHDRBS1, CPSF6, QKI, HNRNPC, PTBP1, RNF213, ELAVL1, IGF2BP3, SRSF1, ZC3HAV1, HNRNPA1, RALY, ADAR, SND1, RBMS1, RBM10 |
| extranodal nasal NK/T cell lymphoma | 10/25 | 0.017026 | 1.97x | PSIP1, CPEB3, FUS, FUBP1, HNRNPA2B1, RNF213, EWSR1, QKI, SPEN, SND1 |
| neoplasm | 32/117 | 0.026352 | 1.35x | PSIP1, CPEB3, HNRNPA2B1, SRSF3, G3BP1, AGO2, KHDRBS1, FUBP1, DKC1, TIA1, QKI, SPEN, HNRNPC, PTBP1, RBMS3, UPF1, RNF213, SF3B6, ELAVL1, EWSR1 |
| female breast carcinoma | 12/34 | 0.026746 | 1.74x | PSIP1, CPEB3, FUS, PABPC1, HNRNPA2B1, RNF213, EWSR1, QKI, SPEN, SND1, RBM10, ZRSR2 |
| skin carcinoma | 14/42 | 0.028544 | 1.64x | PSIP1, CPEB3, FUS, PABPC1, HNRNPA2B1, SRSF3, RALY, RNF213, EWSR1, QKI, SPEN, SND1, RBM10, ZRSR2 |
| Seizure | 6/13 | 0.030571 | 2.28x | PABPC1, AGO2, RNF213, SRRM2, HNRNPU, EFTUD2 |
| colorectal carcinoma | 11/31 | 0.032303 | 1.75x | KHDRBS1, UPF1, HNRNPA1, HNRNPA2B1, SRSF3, RBM39, AGO2, ELAVL1, ADAR, IGF2BP3, PTBP1 |
| diffuse gastric adenocarcinoma | 9/24 | 0.036306 | 1.85x | PSIP1, PABPC1, FUBP1, HNRNPA2B1, SRSF3, RNF213, QKI, SPEN, RBM10 |
| gastric cancer | 9/24 | 0.036306 | 1.85x | KHDRBS1, HNRNPA1, HNRNPA2B1, PTBP3, G3BP1, ELAVL1, ADAR, IGF2BP3, PTBP1 |
| undifferentiated pleomorphic sarcoma | 9/24 | 0.036306 | 1.85x | PSIP1, CPEB3, FUS, RNF213, EWSR1, QKI, SPEN, SND1, ZRSR2 |
| myxedema | 2/2 | 0.040879 | 4.93x | SRRT, AGO2 |
| self-injurious ideation | 2/2 | 0.040879 | 4.93x | CWC22, EFTUD2 |
| amyotrophic lateral sclerosis | 8/21 | 0.043567 | 1.88x | KHDRBS1, FUS, HNRNPA1, HNRNPA2B1, MATR3, RBM45, EWSR1, TARDBP |
| Small Intestinal Tubulovillous Adenoma | 9/25 | 0.047150 | 1.78x | FUS, FUBP1, RNF213, EWSR1, QKI, SPEN, SND1, RBM10, ZRSR2 |
| hepatocellular carcinoma | 30/113 | 0.047409 | 1.31x | PSIP1, CPEB3, HNRNPA2B1, SRSF3, AGO2, TARDBP, KHDRBS1, PABPC1, ZC3H13, FUBP1, CPSF6, QKI, SPEN, HNRNPC, ZRSR2, PTBP1, UPF1, HSPA8, RNF213, ELAVL1 |
💡 说明：
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集