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🔬 剪接因子 QKI 靶基因疾病富集分析
| 疾病名称 | Overlap | P-value | 富集倍数 | 相关靶基因 |
|---|---|---|---|---|
| thyroid neoplasm | 8/16 | 0.006927 | 2.47x | FUS, SPEN, HNRNPA2B1, PSIP1, RNF213, SND1, PABPC1, CPEB3 |
| Rhabdoid Meningioma | 5/8 | 0.010585 | 3.08x | EWSR1, PSIP1, RNF213, FUBP1, CPEB3 |
| response to xenobiotic stimulus | 6/11 | 0.011787 | 2.69x | PTBP2, EWSR1, CPSF6, PRPF40A, CPEB4, SND1 |
| cancer | 20/62 | 0.013430 | 1.59x | SRSF1, KHDRBS1, RNF213, ZC3HAV1, ELAVL1, ADAR, CPSF6, HNRNPA2B1, QKI, IGF2BP3, HNRNPC, HNRNPA1, RALY, PSIP1, AGO2, RBMS1, RBM10, SRSF3, SND1, PTBP1 |
| extranodal nasal NK/T cell lymphoma | 10/25 | 0.017026 | 1.97x | FUS, SPEN, EWSR1, HNRNPA2B1, PSIP1, RNF213, FUBP1, SND1, QKI, CPEB3 |
| neoplasm | 32/117 | 0.026352 | 1.35x | SRSF1, DKC1, KHDRBS1, HNRNPK, RNF213, CPEB4, MBNL1, ELAVL1, EWSR1, ADAR, HNRNPA2B1, UPF1, QKI, IGF2BP3, HNRNPC, HNRNPU, RBM5, PSIP1, PTBP3, AGO2 |
| female breast carcinoma | 12/34 | 0.026746 | 1.74x | FUS, ZRSR2, PABPC1, SPEN, EWSR1, RBM10, HNRNPA2B1, PSIP1, RNF213, SND1, QKI, CPEB3 |
| skin carcinoma | 14/42 | 0.028544 | 1.64x | FUS, ZRSR2, PABPC1, SPEN, EWSR1, RBM10, HNRNPA2B1, RALY, PSIP1, RNF213, SRSF3, SND1, QKI, CPEB3 |
| Seizure | 6/13 | 0.030571 | 2.28x | HNRNPU, EFTUD2, SRRM2, RNF213, AGO2, PABPC1 |
| colorectal carcinoma | 11/31 | 0.032303 | 1.75x | IGF2BP3, ELAVL1, HNRNPA1, KHDRBS1, ADAR, RBM39, HNRNPA2B1, UPF1, SRSF3, AGO2, PTBP1 |
| gastric cancer | 9/24 | 0.036306 | 1.85x | IGF2BP3, ELAVL1, HNRNPA1, KHDRBS1, ADAR, HNRNPA2B1, G3BP1, PTBP3, PTBP1 |
| undifferentiated pleomorphic sarcoma | 9/24 | 0.036306 | 1.85x | FUS, ZRSR2, SPEN, EWSR1, PSIP1, RNF213, SND1, QKI, CPEB3 |
| diffuse gastric adenocarcinoma | 9/24 | 0.036306 | 1.85x | PABPC1, SPEN, RBM10, HNRNPA2B1, PSIP1, RNF213, SRSF3, FUBP1, QKI |
| myxedema | 2/2 | 0.040879 | 4.93x | SRRT, AGO2 |
| self-injurious ideation | 2/2 | 0.040879 | 4.93x | CWC22, EFTUD2 |
| amyotrophic lateral sclerosis | 8/21 | 0.043567 | 1.88x | FUS, RBM45, HNRNPA1, EWSR1, KHDRBS1, HNRNPA2B1, TARDBP, MATR3 |
| Small Intestinal Tubulovillous Adenoma | 9/25 | 0.047150 | 1.78x | FUS, ZRSR2, SPEN, EWSR1, RBM10, RNF213, FUBP1, SND1, QKI |
| hepatocellular carcinoma | 30/113 | 0.047409 | 1.31x | FUS, SRSF1, ZRSR2, KHDRBS1, HNRNPK, RNF213, DDX17, PABPC1, ELAVL1, EWSR1, ADAR, CPSF6, HNRNPA2B1, UPF1, HSPA8, QKI, IGF2BP3, HNRNPC, HNRNPA1, PSIP1 |
💡 说明：
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集