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🔬 剪接因子 RBM39 靶基因疾病富集分析
| 疾病名称 | Overlap | P-value | 富集倍数 | 相关靶基因 |
|---|---|---|---|---|
| neurodegenerative disease | 141/422 | 0.000955 | 1.14x | CDC5L, SRSF3, MATR3, SART3, SAFB2, SF3A1, HTATSF1, RNF20, RBM39, RBM4, SRRM1, NXF1, ZCRB1, CWC22, RBM27, DHX38, RBMX, DDX6, ZRANB2, TRA2A |
| oral squamous cell carcinoma | 19/37 | 0.003093 | 1.75x | NONO, HNRNPA2B1, CRNKL1, RBM15, DDX5, PABPC1, FUBP1, SF3B1, ZCCHC8, QKI, SPEN, DDX6, NUMA1, RNF213, EWSR1, THRAP3, DDX3X, SND1, RBM10 |
| pulmonary large cell neuroendocrine carcinoma | 12/23 | 0.016169 | 1.78x | FUBP1, DDX3X, HNRNPA2B1, SF3B1, ZCCHC8, RNF213, SFPQ, QKI, SND1, RBM10, THRAP3, DDX5 |
| hepatocellular carcinoma | 43/113 | 0.017836 | 1.3x | NONO, CDC5L, YBX1, HNRNPA2B1, SRSF3, AGO2, CRNKL1, RBM15, TARDBP, DDX5, KHDRBS1, PABPC1, ZC3H13, FUBP1, SF3B1, ZCCHC8, CPSF6, QKI, SPEN, HNRNPC |
| bile duct adenocarcinoma | 20/45 | 0.018492 | 1.52x | NONO, HNRNPA2B1, SRSF3, CRNKL1, RBM15, DDX5, PABPC1, FUBP1, SF3B1, QKI, SPEN, DDX6, NUMA1, RNF213, EWSR1, FUS, DDX3X, SFPQ, SND1, RBM10 |
| digestive system melanoma | 11/21 | 0.020499 | 1.79x | FUS, FUBP1, DDX6, DDX3X, SF3B1, CRNKL1, RNF213, EWSR1, SPEN, SND1, RBM10 |
| breast carcinoma | 26/63 | 0.022434 | 1.41x | NONO, HNRNPA2B1, SRSF3, CRNKL1, RBM15, FAM50A, DDX5, PABPC1, FUBP1, SF3B1, ZCCHC8, QKI, SPEN, DDX6, NUMA1, RNF213, EWSR1, THRAP3, ZC3H11A, FUS |
| acute myeloid leukemia | 26/63 | 0.022434 | 1.41x | NONO, HNRNPA2B1, SRSF3, CRNKL1, RBM15, DDX5, PABPC1, FUBP1, SF3B1, ZCCHC8, QKI, SPEN, ZCRB1, DDX6, DDX41, NUMA1, RNF213, EWSR1, IGF2BP3, THRAP3 |
| Duodenal Adenocarcinoma | 19/43 | 0.023147 | 1.51x | NONO, HNRNPA2B1, CRNKL1, DDX5, FUBP1, SF3B1, ZCCHC8, QKI, SPEN, DDX6, NUMA1, RNF213, EWSR1, THRAP3, FUS, DDX3X, SFPQ, SND1, RBM10 |
| salivary gland adenoid cystic carcinoma | 12/24 | 0.024099 | 1.7x | NONO, FUBP1, DDX6, DDX3X, HNRNPA2B1, SF3B1, CRNKL1, NUMA1, SFPQ, SPEN, SND1, DDX5 |
| Gastric Adenoma | 12/24 | 0.024099 | 1.7x | FUS, DDX6, DDX3X, ZCCHC8, NUMA1, CRNKL1, RNF213, SFPQ, QKI, SPEN, SND1, THRAP3 |
| gastric ulcer | 3/3 | 0.024944 | 3.41x | RBM33, HNRNPLL, SND1 |
| skin angiosarcoma | 3/3 | 0.024944 | 3.41x | DDX3X, SND1, RNF213 |
| cecum adenocarcinoma | 23/55 | 0.026629 | 1.43x | NONO, HNRNPA2B1, SRSF3, CRNKL1, RBM15, DDX5, PABPC1, FUBP1, SF3B1, ZCCHC8, QKI, SPEN, DDX6, NUMA1, RNF213, EWSR1, THRAP3, FUS, DDX3X, SFPQ |
| melanoma | 23/55 | 0.026629 | 1.43x | NONO, YBX1, CRNKL1, RBM15, DDX5, PABPC1, FUBP1, SF3B1, ZCCHC8, QKI, SPEN, DDX6, NUMA1, RNF213, EWSR1, THRAP3, FUS, DDX3X, RALY, SFPQ |
| chronic lymphocytic leukemia | 20/47 | 0.031260 | 1.45x | HNRNPA2B1, SRSF3, RBM15, DDX5, FUBP1, SF3B1, ZCCHC8, QKI, SPEN, NXF1, DDX6, NUMA1, RNF213, EWSR1, THRAP3, FUS, DDX3X, SND1, RBM10, PCBP1 |
| brain glioblastoma | 22/53 | 0.032870 | 1.42x | NONO, HNRNPA2B1, SRSF3, CRNKL1, RBM15, DDX5, PABPC1, FUBP1, SF3B1, ZCCHC8, QKI, SPEN, DDX6, NUMA1, RNF213, EWSR1, THRAP3, FUS, DDX3X, SFPQ |
| meningioma | 7/12 | 0.032891 | 1.99x | FUS, FUBP1, DDX3X, ZCCHC8, RNF213, SFPQ, EWSR1 |
| cancer | 25/62 | 0.034235 | 1.37x | YBX1, HNRNPA2B1, SRSF3, AGO2, RBM15, DDX5, KHDRBS1, SNW1, SF3B1, CPSF6, QKI, HNRNPC, PTBP1, RNF213, IGF2BP3, CCAR2, SRSF1, EIF4A3, ZC3HAV1, HNRNPA1 |
| prostate carcinoma | 28/71 | 0.034647 | 1.34x | NONO, ZNF131, HNRNPA2B1, SRSF3, CRNKL1, RBM15, DDX5, PABPC1, FUBP1, SF3B1, ZCCHC8, QKI, SPEN, CWC22, DDX6, NUMA1, RNF213, EWSR1, MBNL1, THRAP3 |
| skin carcinoma | 18/42 | 0.037566 | 1.46x | FUS, PABPC1, DDX6, DDX3X, SRSF3, RALY, CRNKL1, HNRNPA2B1, RNF213, SF3B1, NUMA1, EWSR1, QKI, ZCCHC8, SPEN, SND1, RBM10, THRAP3 |
| superficial spreading melanoma | 19/45 | 0.038751 | 1.44x | NONO, HNRNPA2B1, SRSF3, CRNKL1, RBM15, DDX5, FUBP1, SF3B1, QKI, SPEN, DDX6, NUMA1, RNF213, EWSR1, THRAP3, DDX3X, SND1, RBM10, PCBP1 |
| small cell lung carcinoma | 20/48 | 0.039716 | 1.42x | NONO, HNRNPA2B1, CRNKL1, RBM15, DDX5, PABPC1, FUBP1, SF3B1, ZCCHC8, QKI, SPEN, DDX6, NUMA1, RNF213, EWSR1, FUS, DDX3X, SFPQ, SND1, RBM10 |
| Merkel cell skin cancer | 14/31 | 0.040746 | 1.54x | FUS, FUBP1, DDX6, DDX3X, SF3B1, ZCCHC8, CRNKL1, RNF213, SFPQ, EWSR1, QKI, SPEN, SND1, RBM10 |
| medulloblastoma | 6/10 | 0.041338 | 2.05x | CCAR1, NONO, DDX3X, DDX6, SF3B1, RNF213 |
| glioma | 25/63 | 0.041999 | 1.35x | NONO, YBX1, HNRNPA2B1, SRSF3, RBM15, PCBP2, DDX5, KHDRBS1, FUBP1, SF3B1, QKI, SPEN, PTBP1, NUMA1, RNF213, EWSR1, IGF2BP3, THRAP3, SRSF1, CPEB4 |
| lung adenocarcinoma | 25/63 | 0.041999 | 1.35x | NONO, YBX1, HNRNPA2B1, SRSF3, CRNKL1, RBM15, DDX5, PABPC1, FUBP1, SF3B1, ZCCHC8, QKI, SPEN, DDX6, NUMA1, RNF213, EWSR1, IGF2BP3, THRAP3, FUS |
| female breast carcinoma | 15/34 | 0.043107 | 1.5x | FUS, PABPC1, DDX3X, HNRNPA2B1, SF3B1, NUMA1, CRNKL1, RNF213, EWSR1, QKI, SPEN, SND1, RBM10, THRAP3, DDX5 |
| genetic disorder | 41/113 | 0.048511 | 1.24x | NONO, HNRNPUL2, HNRNPA2B1, AGO2, MATR3, RNPC3, TARDBP, FAM50A, DDX23, SPEN, HNRNPC, EFTUD2, THOC2, RBMX, FMR1, SSB, DDX6, DDX41, PABPN1, RNF213 |
| Extramammary Paget Disease | 9/18 | 0.049680 | 1.7x | FUS, DDX3X, NUMA1, SFPQ, QKI, SPEN, SND1, RBM10, DDX5 |
💡 说明：
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集