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🔬 剪接因子 RBM39 靶基因疾病富集分析
| 疾病名称 | Overlap | P-value | 富集倍数 | 相关靶基因 |
|---|---|---|---|---|
| neurodegenerative disease | 141/422 | 0.000955 | 1.14x | SF3B1, SRSF1, DHX38, HNRNPK, RBM17, RBMX2, DDX17, PABPC1, MBNL1, WBP4, LUC7L3, SART3, EIF4B, SYF2, SNRNP70, FAM50A, ZCCHC8, HNRNPC, SRSF7, SRSF11 |
| oral squamous cell carcinoma | 19/37 | 0.003093 | 1.75x | SF3B1, THRAP3, RNF213, PABPC1, CRNKL1, EWSR1, HNRNPA2B1, RBM15, QKI, ZCCHC8, NUMA1, FUBP1, NONO, DDX5, SPEN, RBM10, DDX6, DDX3X, SND1 |
| pulmonary large cell neuroendocrine carcinoma | 12/23 | 0.016169 | 1.78x | ZCCHC8, SF3B1, DDX5, THRAP3, SFPQ, RBM10, HNRNPA2B1, RNF213, FUBP1, DDX3X, SND1, QKI |
| hepatocellular carcinoma | 43/113 | 0.017836 | 1.3x | FUS, SF3B1, SRSF1, THRAP3, SFPQ, KHDRBS1, HNRNPK, RNF213, PCBP1, DDX17, PABPC1, EIF4A3, SRSF10, CRNKL1, EWSR1, ADAR, CPSF6, HNRNPA2B1, UPF1, HSPA8 |
| bile duct adenocarcinoma | 20/45 | 0.018492 | 1.52x | FUS, SF3B1, SFPQ, RNF213, PABPC1, CRNKL1, EWSR1, HNRNPA2B1, RBM15, QKI, NUMA1, NONO, FUBP1, DDX5, SPEN, RBM10, SRSF3, DDX6, DDX3X, SND1 |
| digestive system melanoma | 11/21 | 0.020499 | 1.79x | FUS, SF3B1, CRNKL1, SPEN, EWSR1, RBM10, RNF213, FUBP1, DDX6, DDX3X, SND1 |
| acute myeloid leukemia | 26/63 | 0.022434 | 1.41x | FUS, SF3B1, THRAP3, SFPQ, U2AF2, RNF213, PABPC1, CRNKL1, EWSR1, HNRNPA2B1, RBM15, QKI, IGF2BP3, ZCCHC8, NUMA1, ZCRB1, NONO, FUBP1, DDX5, SPEN |
| breast carcinoma | 26/63 | 0.022434 | 1.41x | FUS, SF3B1, THRAP3, SFPQ, RNF213, PABPC1, CRNKL1, EWSR1, ADAR, HNRNPA2B1, RBM15, QKI, FAM50A, ZCCHC8, NUMA1, RALY, NONO, FUBP1, DDX5, SPEN |
| Duodenal Adenocarcinoma | 19/43 | 0.023147 | 1.51x | FUS, SF3B1, THRAP3, SFPQ, RNF213, CRNKL1, EWSR1, HNRNPA2B1, QKI, ZCCHC8, NUMA1, FUBP1, NONO, DDX5, SPEN, RBM10, DDX6, DDX3X, SND1 |
| salivary gland adenoid cystic carcinoma | 12/24 | 0.024099 | 1.7x | NUMA1, SF3B1, FUBP1, DDX5, SPEN, SFPQ, CRNKL1, HNRNPA2B1, NONO, DDX6, DDX3X, SND1 |
| Gastric Adenoma | 12/24 | 0.024099 | 1.7x | ZCCHC8, FUS, NUMA1, CRNKL1, SPEN, SFPQ, THRAP3, RNF213, DDX6, DDX3X, SND1, QKI |
| skin angiosarcoma | 3/3 | 0.024944 | 3.41x | DDX3X, SND1, RNF213 |
| gastric ulcer | 3/3 | 0.024944 | 3.41x | RBM33, HNRNPLL, SND1 |
| melanoma | 23/55 | 0.026629 | 1.43x | FUS, SF3B1, THRAP3, SFPQ, RNF213, PABPC1, CRNKL1, EWSR1, ADAR, RBM15, YBX1, QKI, ZCCHC8, NUMA1, RALY, NONO, FUBP1, DDX5, SPEN, RBM10 |
| cecum adenocarcinoma | 23/55 | 0.026629 | 1.43x | FUS, SF3B1, THRAP3, SFPQ, RNF213, PCBP1, PABPC1, CRNKL1, EWSR1, HNRNPA2B1, RBM15, QKI, ZCCHC8, NUMA1, NONO, FUBP1, DDX5, SPEN, RBM10, SRSF3 |
| chronic lymphocytic leukemia | 20/47 | 0.031260 | 1.45x | FUS, SF3B1, THRAP3, RNF213, PCBP1, EWSR1, HNRNPA2B1, RBM15, QKI, ZCCHC8, NUMA1, FUBP1, DDX5, SPEN, RBM10, SRSF3, DDX6, DDX3X, SND1, NXF1 |
| brain glioblastoma | 22/53 | 0.032870 | 1.42x | FUS, SF3B1, THRAP3, SFPQ, RNF213, PABPC1, CRNKL1, EWSR1, HNRNPA2B1, RBM15, QKI, ZCCHC8, NUMA1, NONO, FUBP1, DDX5, SPEN, RBM10, SRSF3, DDX6 |
| meningioma | 7/12 | 0.032891 | 1.99x | ZCCHC8, FUS, EWSR1, SFPQ, RNF213, FUBP1, DDX3X |
| cancer | 25/62 | 0.034235 | 1.37x | SF3B1, SRSF1, KHDRBS1, SNW1, RNF213, EIF4A3, ZC3HAV1, ADAR, CPSF6, HNRNPA2B1, RBM15, YBX1, QKI, IGF2BP3, HNRNPC, HNRNPA1, RALY, AGO2, CCAR2, DDX5 |
| prostate carcinoma | 28/71 | 0.034647 | 1.34x | FUS, SF3B1, THRAP3, SFPQ, RNF213, PABPC1, MBNL1, SRSF10, CRNKL1, EWSR1, HNRNPA2B1, RBM15, QKI, ZCCHC8, NUMA1, RALY, NONO, FUBP1, GPATCH8, DDX5 |
| skin carcinoma | 18/42 | 0.037566 | 1.46x | ZCCHC8, FUS, SF3B1, NUMA1, PABPC1, CRNKL1, SPEN, EWSR1, THRAP3, RBM10, HNRNPA2B1, RALY, RNF213, SRSF3, DDX6, DDX3X, SND1, QKI |
| superficial spreading melanoma | 19/45 | 0.038751 | 1.44x | SF3B1, THRAP3, RNF213, PCBP1, CRNKL1, EWSR1, HNRNPA2B1, RBM15, QKI, NUMA1, FUBP1, NONO, DDX5, SPEN, RBM10, SRSF3, DDX6, DDX3X, SND1 |
| small cell lung carcinoma | 20/48 | 0.039716 | 1.42x | FUS, SF3B1, SFPQ, RNF213, PABPC1, CRNKL1, EWSR1, HNRNPA2B1, RBM15, QKI, ZCCHC8, NUMA1, NONO, FUBP1, DDX5, SPEN, RBM10, DDX6, DDX3X, SND1 |
| Merkel cell skin cancer | 14/31 | 0.040746 | 1.54x | ZCCHC8, FUS, SF3B1, CRNKL1, SPEN, EWSR1, SFPQ, RBM10, RNF213, FUBP1, DDX6, DDX3X, SND1, QKI |
| medulloblastoma | 6/10 | 0.041338 | 2.05x | SF3B1, RNF213, NONO, DDX6, CCAR1, DDX3X |
| glioma | 25/63 | 0.041999 | 1.35x | FUS, SF3B1, SRSF1, THRAP3, KHDRBS1, RNF213, CPEB4, PCBP1, EWSR1, HNRNPA2B1, RBM15, YBX1, QKI, IGF2BP3, NUMA1, NONO, FUBP1, DDX5, SPEN, RBM10 |
| lung adenocarcinoma | 25/63 | 0.041999 | 1.35x | FUS, SF3B1, THRAP3, SFPQ, RNF213, PCBP1, PABPC1, CRNKL1, EWSR1, HNRNPA2B1, RBM15, YBX1, QKI, IGF2BP3, ZCCHC8, NUMA1, NONO, FUBP1, DDX5, SPEN |
| female breast carcinoma | 15/34 | 0.043107 | 1.5x | NUMA1, FUS, SF3B1, PABPC1, DDX5, SPEN, EWSR1, CRNKL1, RBM10, THRAP3, HNRNPA2B1, RNF213, DDX3X, SND1, QKI |
| genetic disorder | 41/113 | 0.048511 | 1.24x | FUS, SRSF1, HNRNPK, SSB, IK, U2AF2, RNF213, PCBP1, FMR1, EIF4A3, RNPC3, HNRNPUL2, ADAR, HNRNPA2B1, THOC2, SF3B2, HNRNPU, FAM50A, HNRNPC, SNRNP200 |
| Extramammary Paget Disease | 9/18 | 0.049680 | 1.7x | NUMA1, FUS, DDX5, SPEN, SFPQ, RBM10, DDX3X, SND1, QKI |
💡 说明：
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集