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🔬 剪接因子 SAFB 靶基因疾病富集分析
| 疾病名称 | Overlap | P-value | 富集倍数 | 相关靶基因 |
|---|---|---|---|---|
| gastric ulcer | 3/3 | 0.003168 | 6.75x | RBM33, HNRNPLL, SND1 |
| pulmonary large cell neuroendocrine carcinoma | 9/23 | 0.003247 | 2.64x | ZCCHC8, SF3B1, DDX5, THRAP3, SFPQ, HNRNPA2B1, FUBP1, SND1, QKI |
| teratoma | 3/4 | 0.011302 | 5.06x | DDX6, SND1, PABPC1 |
| oral squamous cell carcinoma | 11/37 | 0.012898 | 2.01x | ZCCHC8, SF3B1, PABPC1, DDX5, SPEN, THRAP3, HNRNPA2B1, FUBP1, DDX6, SND1, QKI |
| Gallbladder Adenocarcinoma | 11/38 | 0.015928 | 1.95x | FUS, SF3B1, DDX5, SPEN, SFPQ, THRAP3, HNRNPA2B1, FUBP1, DDX6, SND1, PABPC1 |
| Duodenal Adenocarcinoma | 12/43 | 0.016063 | 1.88x | ZCCHC8, FUS, SF3B1, DDX5, SPEN, SFPQ, THRAP3, HNRNPA2B1, FUBP1, DDX6, SND1, QKI |
| diffuse gastric adenocarcinoma | 8/24 | 0.016591 | 2.25x | SF3B1, PABPC1, THRAP3, SPEN, HNRNPA2B1, FUBP1, DDX6, QKI |
| Gastric Adenoma | 8/24 | 0.016591 | 2.25x | ZCCHC8, FUS, THRAP3, SPEN, SFPQ, DDX6, SND1, QKI |
| salivary gland adenoid cystic carcinoma | 8/24 | 0.016591 | 2.25x | SF3B1, DDX5, SPEN, SFPQ, HNRNPA2B1, FUBP1, DDX6, SND1 |
| Ampulla of Vater Carcinoma | 7/20 | 0.018857 | 2.36x | ZCCHC8, SF3B1, THRAP3, SPEN, HNRNPA2B1, FUBP1, SND1 |
| T-cell large granular lymphocyte leukemia | 4/8 | 0.019745 | 3.37x | DDX6, SFPQ, SND1, HNRNPA2B1 |
| prostate carcinoma | 17/71 | 0.021174 | 1.62x | ZCCHC8, FUS, SRSF10, SF3B1, FUBP1, PABPC1, DDX5, SPEN, SFPQ, THRAP3, HNRNPA2B1, ZNF131, DDX6, GPATCH8, SND1, QKI, MBNL1 |
| Sensorineural hearing impairment | 3/5 | 0.025220 | 4.05x | ZFR, QKI, RBPMS |
| osteoarthritis, hip | 3/5 | 0.025220 | 4.05x | CDC5L, SART1, QKI |
| Endometrial Serous Adenocarcinoma | 3/5 | 0.025220 | 4.05x | DDX6, FUS, SND1 |
| Abnormality of the gastrointestinal tract | 3/5 | 0.025220 | 4.05x | TIAL1, SAFB2, SSB |
| pancreatic neoplasm | 3/5 | 0.025220 | 4.05x | DDX6, SF3B1, SND1 |
| Placental Choriocarcinoma | 6/17 | 0.028340 | 2.38x | FUS, SF3B1, SPEN, SFPQ, DDX6, QKI |
| Merkel cell skin cancer | 9/31 | 0.028362 | 1.96x | ZCCHC8, FUS, SF3B1, SPEN, SFPQ, FUBP1, DDX6, SND1, QKI |
| brain glioblastoma | 13/53 | 0.035969 | 1.66x | ZCCHC8, FUS, SF3B1, PABPC1, DDX5, SPEN, SFPQ, THRAP3, HNRNPA2B1, FUBP1, DDX6, SND1, QKI |
| Extramammary Paget Disease | 6/18 | 0.037514 | 2.25x | FUS, DDX5, SPEN, SFPQ, SND1, QKI |
| small cell lung carcinoma | 12/48 | 0.037896 | 1.69x | ZCCHC8, FUS, SF3B1, PABPC1, DDX5, SPEN, SFPQ, HNRNPA2B1, FUBP1, DDX6, SND1, QKI |
| metaplastic breast carcinoma | 7/23 | 0.040744 | 2.05x | FUS, PABPC1, DDX5, SPEN, THRAP3, SND1, QKI |
| anaplastic oligodendroglioma | 7/23 | 0.040744 | 2.05x | SF3B1, PABPC1, SPEN, FUBP1, DDX6, SND1, QKI |
| kidney neoplasm | 12/49 | 0.044031 | 1.65x | FUS, SF3B1, PABPC1, DDX5, SPEN, SFPQ, THRAP3, HNRNPA2B1, FUBP1, DDX6, SND1, QKI |
| breast ductal adenocarcinoma | 14/60 | 0.044616 | 1.57x | ZCCHC8, FUS, SF3B1, PABPC1, DDX5, SPEN, SFPQ, AKAP1, THRAP3, HNRNPA2B1, FUBP1, DDX6, SND1, QKI |
| hearing loss | 3/6 | 0.045061 | 3.37x | ZFR, QKI, RBPMS |
| colon carcinoma | 3/6 | 0.045061 | 3.37x | SPEN, SND1, HNRNPA2B1 |
| bile duct carcinoma | 13/55 | 0.047717 | 1.59x | ZCCHC8, FUS, SF3B1, PABPC1, DDX5, SPEN, SFPQ, THRAP3, HNRNPA2B1, FUBP1, DDX6, SND1, QKI |
| carcinoma of liver and intrahepatic biliary tract | 13/55 | 0.047717 | 1.59x | ZCCHC8, FUS, SF3B1, PABPC1, DDX5, SPEN, SFPQ, THRAP3, HNRNPA2B1, FUBP1, DDX6, SND1, QKI |
💡 说明：
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集