🔬 剪接因子 SAFB2 靶基因疾病富集分析

疾病名称	Overlap	P-value	富集倍数	相关靶基因
gastric cancer	7/24	0.021384	2.34x	KHDRBS1, HNRNPA1, HNRNPA2B1, PTBP3, ELAVL1, IGF2BP3, PCBP1
colon carcinoma	3/6	0.028340	4.01x	SND1, HNRNPA2B1, SPEN
triple-negative breast cancer	3/6	0.028340	4.01x	ELAVL1, IGF2BP3, YBX1
colorectal carcinoma	8/31	0.029341	2.07x	KHDRBS1, YBX1, HNRNPA1, HNRNPA2B1, RBM39, ELAVL1, DDX21, IGF2BP3
amyotrophic lateral sclerosis	6/21	0.036263	2.29x	KHDRBS1, FUS, HNRNPA1, HNRNPA2B1, MATR3, RBM45
myoepithelial tumor	5/16	0.038380	2.5x	FUS, NUMA1, RBM12B, RBM4, SPEN
neurodegenerative disease	60/422	0.040426	1.14x	CHERP, ZNF131, CELF1, HNRNPA2B1, MATR3, HNRNPF, SREK1, RBM15, SAFB2, HNRNPUL1, THOC1, PCBP2, SAFB, SFSWAP, LUC7L3, ZCCHC8, RBM39, PNN, SRPK1, PPIG
Cachexia	2/3	0.042456	5.34x	HNRNPU, ZC3H18
gastric ulcer	2/3	0.042456	5.34x	RBM33, SND1
distal myopathy	2/3	0.042456	5.34x	HNRNPA1, MATR3
sinusitis	2/3	0.042456	5.34x	ELAVL1, MBNL2
classic medulloblastoma	2/3	0.042456	5.34x	HNRNPA2B1, SND1
disease of peritoneum	2/3	0.042456	5.34x	QKI, SSB

💡 说明：
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集