🔬 剪接因子 SAFB2 靶基因疾病富集分析

疾病名称	Overlap	P-value	富集倍数	相关靶基因
gastric cancer	7/24	0.021384	2.34x	ELAVL1, HNRNPA1, KHDRBS1, HNRNPA2B1, PTBP3, PCBP1, IGF2BP3
colon carcinoma	3/6	0.028340	4.01x	SPEN, SND1, HNRNPA2B1
triple-negative breast cancer	3/6	0.028340	4.01x	YBX1, IGF2BP3, ELAVL1
colorectal carcinoma	8/31	0.029341	2.07x	ELAVL1, HNRNPA1, DDX21, KHDRBS1, RBM39, HNRNPA2B1, YBX1, IGF2BP3
amyotrophic lateral sclerosis	6/21	0.036263	2.29x	FUS, RBM45, HNRNPA1, KHDRBS1, HNRNPA2B1, MATR3
myoepithelial tumor	5/16	0.038380	2.5x	NUMA1, FUS, SPEN, RBM12B, RBM4
neurodegenerative disease	60/422	0.040426	1.14x	RBM26, PNN, SSB, HNRNPUL1, RBM12, THOC1, CNOT4, PCBP1, PRPF19, TRA2A, TRNAU1AP, CCDC12, MBNL1, SRSF10, ELAVL1, PPIL2, RBM39, PPIH, ANKHD1, LUC7L3
distal myopathy	2/3	0.042456	5.34x	HNRNPA1, MATR3
disease of peritoneum	2/3	0.042456	5.34x	SSB, QKI
Cachexia	2/3	0.042456	5.34x	HNRNPU, ZC3H18
classic medulloblastoma	2/3	0.042456	5.34x	SND1, HNRNPA2B1
sinusitis	2/3	0.042456	5.34x	MBNL2, ELAVL1
gastric ulcer	2/3	0.042456	5.34x	SND1, RBM33

💡 说明：
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集