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🔬 剪接因子 SF3A3 靶基因疾病富集分析
| 疾病名称 | Overlap | P-value | 富集倍数 | 相关靶基因 |
|---|---|---|---|---|
| Gallbladder Adenocarcinoma | 18/38 | 0.004451 | 1.76x | NUMA1, SF3B1, FUS, FUBP1, PABPC1, DDX5, SPEN, SFPQ, U2AF1, RBM10, THRAP3, HNRNPA2B1, ZMYM3, RNF213, NONO, DDX3X, SND1, PRCC |
| gastric intestinal type adenocarcinoma | 19/41 | 0.004721 | 1.72x | FUS, THRAP3, RNF213, PABPC1, EWSR1, HNRNPA2B1, QKI, NUMA1, U2AF1, ZMYM3, FUBP1, NONO, SRSF2, DDX5, SPEN, RBM10, DDX3X, SND1, PRCC |
| acute myeloid leukemia | 26/63 | 0.006886 | 1.53x | FUS, SF3B1, THRAP3, SFPQ, U2AF2, RNF213, PABPC1, EWSR1, HNRNPA2B1, QKI, IGF2BP3, NUMA1, U2AF1, ZMYM3, NONO, FUBP1, SRSF2, DDX5, SPEN, RBM10 |
| female breast carcinoma | 16/34 | 0.007973 | 1.74x | NUMA1, FUS, SF3B1, PABPC1, DDX5, SPEN, EWSR1, THRAP3, RBM10, HNRNPA2B1, QKI, ZMYM3, RNF213, DDX3X, SND1, PRCC |
| Seizure | 8/13 | 0.008667 | 2.28x | HNRNPU, EFTUD2, DHX30, SRRM2, DHX34, RNF213, AGO2, PABPC1 |
| Duodenal Adenocarcinoma | 19/43 | 0.008988 | 1.64x | FUS, SF3B1, THRAP3, SFPQ, RNF213, EWSR1, HNRNPA2B1, QKI, NUMA1, U2AF1, ZMYM3, FUBP1, NONO, DDX5, SPEN, RBM10, DDX3X, SND1, PRCC |
| lung carcinoma | 23/55 | 0.009204 | 1.55x | FUS, SF3B1, THRAP3, SFPQ, RNF213, PABPC1, EWSR1, HNRNPA2B1, QKI, NUMA1, U2AF1, RALY, ZMYM3, NONO, FUBP1, SRSF2, DDX5, SPEN, RBM10, SRSF3 |
| multiple myeloma | 21/49 | 0.009223 | 1.59x | FUS, SF3B1, THRAP3, RNF213, PABPC1, EWSR1, HNRNPA2B1, QKI, NUMA1, U2AF1, ZMYM3, NONO, FUBP1, EFTUD2, SRSF2, DDX5, SPEN, RBM10, DDX3X, SND1 |
| oral cavity carcinoma | 18/41 | 0.011902 | 1.63x | NUMA1, FUS, SF3B1, FUBP1, PABPC1, U2AF1, SPEN, EWSR1, THRAP3, RBM10, QKI, ZMYM3, RNF213, NONO, SRSF3, DDX3X, SND1, PRCC |
| gastric carcinoma | 23/56 | 0.011907 | 1.52x | FUS, SF3B1, THRAP3, SFPQ, RNF213, PABPC1, EWSR1, HNRNPA2B1, QKI, NUMA1, U2AF1, ZMYM3, NONO, FUBP1, DDX19A, SRSF2, DDX5, SPEN, RBM10, SRSF3 |
| brain glioblastoma | 22/53 | 0.012046 | 1.54x | FUS, SF3B1, THRAP3, SFPQ, RNF213, PABPC1, EWSR1, HNRNPA2B1, QKI, NUMA1, U2AF1, ZMYM3, NONO, FUBP1, SRSF2, DDX5, SPEN, RBM10, SRSF3, DDX3X |
| esophageal carcinoma | 12/24 | 0.012115 | 1.85x | NUMA1, FUS, SF3B1, DDX5, SPEN, EWSR1, RBM10, HNRNPA2B1, ZMYM3, RNF213, DDX3X, SND1 |
| salivary gland adenoid cystic carcinoma | 12/24 | 0.012115 | 1.85x | NUMA1, SF3B1, FUBP1, DDX5, SPEN, SFPQ, U2AF1, HNRNPA2B1, ZMYM3, NONO, DDX3X, SND1 |
| central nervous system primitive neuroectodermal neoplasm | 21/50 | 0.012126 | 1.56x | FUS, SF3B1, THRAP3, SFPQ, RNF213, PABPC1, EWSR1, HNRNPA2B1, QKI, NUMA1, U2AF1, ZMYM3, NONO, FUBP1, SRSF2, DDX5, SPEN, RBM10, DDX3X, SND1 |
| autism | 6/9 | 0.014209 | 2.47x | DHX30, PPIL2, SNRPN, THOC2, NONO, XRN2 |
| Atypical Meningioma | 10/19 | 0.014250 | 1.95x | SF3B1, FUS, PABPC1, DDX5, RBM10, RNF213, FUBP1, DDX3X, SND1, PRCC |
| breast carcinoma | 25/63 | 0.014524 | 1.47x | FUS, SF3B1, THRAP3, SFPQ, RNF213, PABPC1, EWSR1, ADAR, HNRNPA2B1, QKI, FAM50A, NUMA1, U2AF1, RALY, ZMYM3, NONO, FUBP1, SRSF2, DDX5, SPEN |
| Intellectual disability | 23/57 | 0.015218 | 1.5x | SNRPB, SRSF1, HNRNPK, U2AF2, DDX17, PABPC1, EIF4A3, PQBP1, DHX30, HNRNPUL2, ZFR, UPF1, THOC2, FAM50A, HNRNPU, PUF60, ZMYM3, AGO2, RBM10, HNRNPD |
| Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation | 21/51 | 0.015720 | 1.53x | FUS, SF3B1, THRAP3, SFPQ, RNF213, PABPC1, EWSR1, HNRNPA2B1, QKI, NUMA1, U2AF1, ZMYM3, NONO, FUBP1, SRSF2, SPEN, RBM10, SRSF3, DDX3X, SND1 |
| gastroesophageal junction adenocarcinoma | 17/39 | 0.015733 | 1.62x | NUMA1, FUS, SRSF2, PABPC1, DDX5, SPEN, U2AF1, THRAP3, RBM10, HNRNPA2B1, PRCC, ZMYM3, RNF213, SRSF3, FUBP1, SND1, QKI |
| papillary thyroid carcinoma | 20/48 | 0.015871 | 1.54x | FUS, SF3B1, THRAP3, SFPQ, RNF213, PABPC1, EWSR1, QKI, NUMA1, U2AF1, ZMYM3, FUBP1, NONO, SRSF2, SPEN, RBM10, SRSF3, DDX3X, SND1, PRCC |
| bile duct adenocarcinoma | 19/45 | 0.015936 | 1.56x | SF3B1, FUS, SFPQ, RNF213, PABPC1, EWSR1, HNRNPA2B1, QKI, NUMA1, U2AF1, ZMYM3, FUBP1, NONO, DDX5, SPEN, RBM10, SRSF3, DDX3X, SND1 |
| Small Intestinal Tubulovillous Adenoma | 12/25 | 0.017856 | 1.78x | NUMA1, FUS, SF3B1, DDX5, SPEN, EWSR1, RBM10, ZMYM3, RNF213, FUBP1, SND1, QKI |
| non-small cell lung carcinoma | 23/58 | 0.019225 | 1.47x | FUS, SF3B1, THRAP3, SFPQ, RNF213, EWSR1, HNRNPA2B1, QKI, NUMA1, RBM5, U2AF1, ZMYM3, NONO, AGO2, FUBP1, SRSF2, DDX5, SPEN, RBM10, SRSF3 |
| genetic disorder | 40/113 | 0.019277 | 1.31x | FUS, SNRPB, SRSF1, HNRNPK, SSB, U2AF2, RNF213, RNF34, EIF4A3, PQBP1, DHX30, HNRNPUL2, ADAR, HNRNPA2B1, THOC2, SF3B2, HNRNPU, FAM50A, PUF60, HNRNPC |
| hepatocellular carcinoma | 40/113 | 0.019277 | 1.31x | FUS, SF3B1, SRSF1, THRAP3, KHDRBS1, SFPQ, HNRNPK, RNF213, DDX17, PABPC1, EIF4A3, SRSF10, PTBP1, EWSR1, ADAR, SUGP1, PPIH, HNRNPA2B1, CPSF6, UPF1 |
| skin angiosarcoma | 3/3 | 0.019410 | 3.71x | DDX3X, SND1, RNF213 |
| gastric ulcer | 3/3 | 0.019410 | 3.71x | RBM33, HNRNPLL, SND1 |
| melanoma | 22/55 | 0.019695 | 1.48x | FUS, SF3B1, THRAP3, SFPQ, RNF213, PABPC1, EWSR1, ADAR, QKI, NUMA1, U2AF1, RALY, ZMYM3, NONO, FUBP1, SRSF2, DDX5, SPEN, RBM10, DDX3X |
| thyroid carcinoma | 22/55 | 0.019695 | 1.48x | FUS, SF3B1, THRAP3, SFPQ, RNF213, PABPC1, EWSR1, HNRNPA2B1, QKI, NUMA1, U2AF1, ZMYM3, NONO, FUBP1, SRSF2, DDX5, SPEN, RBM10, SRSF3, DDX3X |
💡 说明：
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集