🔬 剪接因子 SRSF2 靶基因疾病富集分析

疾病名称	Overlap	P-value	富集倍数	相关靶基因
neurodegenerative disease	146/422	0.002891	1.12x	PSIP1, CDC5L, SRSF3, MATR3, HNRNPF, SART3, SAFB2, SF3A1, HTATSF1, RNF20, RBM39, GPATCH1, SRRM1, NXF1, CWC22, RBM22, RBM27, DHX38, RBMX, ZRANB2
breast carcinoma	27/63	0.023527	1.39x	PSIP1, NONO, HNRNPA2B1, SRSF3, SRSF2, CRNKL1, RBM15, FAM50A, DDX5, PABPC1, FUBP1, SF3B1, ZCCHC8, QKI, NUMA1, EWSR1, THRAP3, ZC3H11A, CSTF2T, FUS
pulmonary large cell neuroendocrine carcinoma	12/23	0.024770	1.69x	PSIP1, FUBP1, DDX3X, HNRNPA2B1, ZCCHC8, SF3B1, SFPQ, QKI, SND1, RBM10, THRAP3, DDX5
autosomal dominant retinitis pigmentosa	4/5	0.033710	2.59x	RP9, PRPF3, PRPF6, SNRNP200
dengue disease	76/212	0.034996	1.16x	CCAR1, SRSF9, SNRPD2, SF3B4, CDC5L, SNRPG, YBX1, HNRNPA2B1, SNRPD1, SRSF3, SNRPN, HNRNPF, CRNKL1, HNRNPUL1, SF3A1, HNRNPM, SF3A3, CTNNBL1, PCBP2, DDX23

💡 说明：
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集