🔬 剪接因子 SRSF2 靶基因疾病富集分析

疾病名称	Overlap	P-value	富集倍数	相关靶基因
neurodegenerative disease	146/422	0.002891	1.12x	SF3B1, SRSF1, DHX38, RBM22, HNRNPK, PRPF38A, RBMX2, DDX17, PABPC1, MBNL1, LUC7L3, SART3, CTNNBL1, EIF4B, SYF2, SNRNP70, FAM50A, ZCCHC8, PLRG1, HNRNPC
breast carcinoma	27/63	0.023527	1.39x	FUS, SF3B1, THRAP3, SFPQ, PABPC1, CRNKL1, EWSR1, ADAR, HNRNPA2B1, RBM15, QKI, FAM50A, ZCCHC8, NUMA1, U2AF1, RALY, PSIP1, NONO, FUBP1, SRSF2
pulmonary large cell neuroendocrine carcinoma	12/23	0.024770	1.69x	ZCCHC8, SF3B1, DDX5, THRAP3, SFPQ, RBM10, HNRNPA2B1, PSIP1, FUBP1, DDX3X, SND1, QKI
autosomal dominant retinitis pigmentosa	4/5	0.033710	2.59x	PRPF6, RP9, PRPF3, SNRNP200
dengue disease	76/212	0.034996	1.16x	FUS, SF3B1, SNRPB, SRSF1, DHX38, SF3B3, HNRNPA3, RBM22, HNRNPK, SNW1, U2AF2, HNRNPUL1, SRSF4, U2AF1L4, PCBP1, SF3B4, SNRPD2, SNRPD1, PABPC1, EIF4A3

💡 说明：
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集