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🔬 剪接因子 SRSF3 靶基因疾病富集分析

疾病名称	Overlap	P-value	富集倍数	相关靶基因
neurodegenerative disease	166/422	0.002405	1.11x	SRSF3, MATR3, HNRNPF, SART3, DBR1, RBM39, GPATCH1, SRRM1, THOC5, RBM4, NXF1, CWC22, RBM27, GEMIN5, DHX38, RBMX, DDX6, PRPF19, ZRANB2, SNRPE
Global developmental delay	12/20	0.019916	1.69x	LSM1, PABPC1, UPF1, DDX6, DDX3X, DDX5, SNRNP70, ZMYM3, DHX30, RBM8A, AAR2, EFTUD2
hepatocellular carcinoma	50/113	0.020805	1.25x	NONO, SF3B4, YBX1, HNRNPA2B1, PRCC, SRSF3, SRSF2, CRNKL1, AGO2, RBM15, TARDBP, DDX5, KHDRBS1, PABPC1, ZC3H13, FUBP1, SF3B1, ZCCHC8, CPSF6, QKI
coronary atherosclerosis	6/8	0.026128	2.12x	GPATCH3, AGO2, SF3A3, CCNL1, ADAR, CPEB4
medulloblastoma	7/10	0.026845	1.98x	CCAR1, NONO, DDX6, SF3B1, DDX3X, RNF213, ZMYM3
oral squamous cell carcinoma	19/37	0.029864	1.45x	NONO, HNRNPA2B1, PRCC, CRNKL1, RBM15, DDX5, PABPC1, FUBP1, SF3B1, ZCCHC8, QKI, SPEN, DDX6, NUMA1, RNF213, EWSR1, THRAP3, DDX3X, RBM10
melanoma	26/55	0.039515	1.33x	NONO, YBX1, PRCC, SRSF2, CRNKL1, RBM15, DDX5, PABPC1, FUBP1, SF3B1, ZCCHC8, QKI, SPEN, DDX6, NUMA1, RNF213, EWSR1, ZMYM3, THRAP3, FUS
Duodenal Adenocarcinoma	21/43	0.042751	1.38x	NONO, HNRNPA2B1, PRCC, CRNKL1, DDX5, FUBP1, SF3B1, ZCCHC8, QKI, SPEN, DDX6, NUMA1, RNF213, EWSR1, ZMYM3, THRAP3, FUS, DDX3X, SFPQ, RBM10
salivary gland adenoid cystic carcinoma	13/24	0.043258	1.53x	NONO, FUBP1, DDX6, DDX3X, HNRNPA2B1, SF3B1, CRNKL1, NUMA1, SFPQ, SPEN, ZMYM3, U2AF1, DDX5
Gastric Adenoma	13/24	0.043258	1.53x	FUS, DDX6, DDX3X, PRCC, NUMA1, CRNKL1, ZCCHC8, RNF213, SFPQ, QKI, SPEN, ZMYM3, THRAP3
acrocephalosyndactyly	3/3	0.044033	2.82x	NCBP1, POLR2G, NCBP2
brain glioblastoma	25/53	0.044535	1.33x	NONO, HNRNPA2B1, PRCC, SRSF3, SRSF2, CRNKL1, RBM15, DDX5, PABPC1, FUBP1, SF3B1, ZCCHC8, QKI, SPEN, DDX6, NUMA1, RNF213, EWSR1, ZMYM3, THRAP3
Seizure	8/13	0.047721	1.74x	PABPC1, AGO2, DHX34, RNF213, SRRM2, HNRNPU, DHX30, EFTUD2
gastric intestinal type adenocarcinoma	20/41	0.048293	1.38x	NONO, HNRNPA2B1, PRCC, SRSF2, RBM15, DDX5, PABPC1, FUBP1, QKI, SPEN, DDX6, NUMA1, RNF213, EWSR1, ZMYM3, THRAP3, FUS, DDX3X, RBM10, U2AF1

💡 说明：
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集