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🔬 剪接因子 SRSF3 靶基因疾病富集分析

疾病名称	Overlap	P-value	富集倍数	相关靶基因
neurodegenerative disease	166/422	0.002405	1.11x	RBM15B, SF3B1, SRSF1, RBM38, DHX38, SAMD4B, HNRNPK, PRPF38A, RBM17, PRPF19, DDX17, PABPC1, MBNL1, DHX30, LUC7L3, SART3, CTNNBL1, EIF4B, SYF2, SNRNP70
Global developmental delay	12/20	0.019916	1.69x	AAR2, PABPC1, DHX30, DDX5, LSM1, SNRNP70, UPF1, ZMYM3, RBM8A, DDX6, DDX3X, EFTUD2
hepatocellular carcinoma	50/113	0.020805	1.25x	FUS, SF3B1, SRSF1, THRAP3, SFPQ, KHDRBS1, HNRNPK, RNF213, PCBP1, SF3B4, PRPF19, DDX17, PABPC1, EIF4A3, SRSF10, PTBP1, ELAVL1, CRNKL1, EWSR1, ADAR
coronary atherosclerosis	6/8	0.026128	2.12x	SF3A3, GPATCH3, ADAR, CPEB4, AGO2, CCNL1
medulloblastoma	7/10	0.026845	1.98x	SF3B1, ZMYM3, RNF213, NONO, DDX6, CCAR1, DDX3X
oral squamous cell carcinoma	19/37	0.029864	1.45x	SF3B1, THRAP3, RNF213, PABPC1, CRNKL1, EWSR1, HNRNPA2B1, RBM15, QKI, ZCCHC8, NUMA1, NONO, FUBP1, DDX5, SPEN, RBM10, DDX6, DDX3X, PRCC
melanoma	26/55	0.039515	1.33x	FUS, SF3B1, THRAP3, SFPQ, RNF213, PABPC1, CRNKL1, EWSR1, ADAR, RBM15, YBX1, QKI, ZCCHC8, NUMA1, U2AF1, RALY, ZMYM3, NONO, FUBP1, SRSF2
Duodenal Adenocarcinoma	21/43	0.042751	1.38x	FUS, SF3B1, THRAP3, SFPQ, RNF213, CRNKL1, EWSR1, HNRNPA2B1, QKI, ZCCHC8, NUMA1, U2AF1, ZMYM3, FUBP1, NONO, DDX5, SPEN, RBM10, DDX6, DDX3X
salivary gland adenoid cystic carcinoma	13/24	0.043258	1.53x	NUMA1, SF3B1, FUBP1, CRNKL1, SPEN, U2AF1, SFPQ, DDX5, HNRNPA2B1, ZMYM3, NONO, DDX6, DDX3X
Gastric Adenoma	13/24	0.043258	1.53x	ZCCHC8, FUS, NUMA1, CRNKL1, SPEN, THRAP3, SFPQ, ZMYM3, RNF213, QKI, DDX6, DDX3X, PRCC
acrocephalosyndactyly	3/3	0.044033	2.82x	NCBP2, POLR2G, NCBP1
brain glioblastoma	25/53	0.044535	1.33x	FUS, SF3B1, THRAP3, SFPQ, RNF213, PABPC1, CRNKL1, EWSR1, HNRNPA2B1, RBM15, QKI, ZCCHC8, NUMA1, U2AF1, ZMYM3, NONO, FUBP1, SRSF2, DDX5, SPEN
Seizure	8/13	0.047721	1.74x	HNRNPU, EFTUD2, DHX30, SRRM2, DHX34, RNF213, AGO2, PABPC1
gastric intestinal type adenocarcinoma	20/41	0.048293	1.38x	FUS, THRAP3, RNF213, PABPC1, EWSR1, HNRNPA2B1, RBM15, QKI, NUMA1, U2AF1, ZMYM3, NONO, FUBP1, SRSF2, DDX5, SPEN, RBM10, DDX6, DDX3X, PRCC

💡 说明：
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集