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🔬 剪接因子 SRSF9 靶基因疾病富集分析
| 疾病名称 | Overlap | P-value | 富集倍数 | 相关靶基因 |
|---|---|---|---|---|
| neurodegenerative disease | 166/422 | 0.002405 | 1.11x | SF3B1, SRSF1, DHX38, SAMD4B, HNRNPK, PRPF38A, RBM17, PRPF19, DDX17, PABPC1, RBPMS, WBP4, DHX30, LUC7L3, EIF4B, LSM4, SNRNP70, ZCCHC8, HNRNPC, PLRG1 |
| melanoma | 28/55 | 0.009978 | 1.44x | FUS, SF3B1, THRAP3, SFPQ, RNF213, A1CF, PABPC1, CRNKL1, EWSR1, ADAR, RBM15, YBX1, QKI, ZCCHC8, NUMA1, CDK10, U2AF1, RALY, ZMYM3, NONO |
| autism | 7/9 | 0.011506 | 2.2x | DHX30, PPIL2, SNRPN, THOC2, NONO, FMR1, XRN2 |
| Duodenal Adenocarcinoma | 22/43 | 0.020752 | 1.44x | FUS, SF3B1, THRAP3, SFPQ, RNF213, A1CF, CRNKL1, EWSR1, HNRNPA2B1, QKI, ZCCHC8, NUMA1, U2AF1, ZMYM3, FUBP1, NONO, DDX5, SPEN, RBM10, DDX3X |
| hepatocellular carcinoma | 50/113 | 0.020805 | 1.25x | FUS, SF3B1, SRSF1, THRAP3, KHDRBS1, SFPQ, HNRNPK, RNF213, PCBP1, A1CF, SF3B4, PRPF19, DDX17, PABPC1, SRSF10, PTBP1, CRNKL1, EWSR1, ADAR, CPSF6 |
| brain glioblastoma | 26/53 | 0.023247 | 1.39x | FUS, SF3B1, THRAP3, SFPQ, RNF213, A1CF, PABPC1, CRNKL1, EWSR1, HNRNPA2B1, RBM15, QKI, ZCCHC8, NUMA1, U2AF1, ZMYM3, NONO, FUBP1, SRSF2, DDX5 |
| gastric intestinal type adenocarcinoma | 21/41 | 0.023430 | 1.45x | FUS, THRAP3, RNF213, A1CF, PABPC1, EWSR1, HNRNPA2B1, RBM15, QKI, NUMA1, U2AF1, ZMYM3, NONO, FUBP1, SRSF2, DDX5, SPEN, RBM10, DDX3X, SND1 |
| acute myeloid leukemia | 30/63 | 0.024418 | 1.34x | FUS, SF3B1, THRAP3, SFPQ, U2AF2, RNF213, A1CF, PABPC1, CRNKL1, EWSR1, HNRNPA2B1, RBM15, QKI, IGF2BP3, ZCCHC8, NUMA1, U2AF1, ZMYM3, NONO, FUBP1 |
| gastric carcinoma | 27/56 | 0.027070 | 1.36x | FUS, SF3B1, THRAP3, SFPQ, RNF213, A1CF, PABPC1, CRNKL1, EWSR1, HNRNPA2B1, RBM15, QKI, ZCCHC8, NUMA1, U2AF1, ZMYM3, NONO, FUBP1, DDX19A, SRSF2 |
| multiple myeloma | 24/49 | 0.029669 | 1.38x | FUS, SF3B1, THRAP3, RNF213, A1CF, PABPC1, CRNKL1, EWSR1, HNRNPA2B1, RBM15, QKI, NUMA1, U2AF1, ZMYM3, NONO, FUBP1, EFTUD2, SRSF2, DDX5, SPEN |
| oral squamous cell carcinoma | 19/37 | 0.029864 | 1.45x | SF3B1, THRAP3, RNF213, PABPC1, CRNKL1, EWSR1, HNRNPA2B1, RBM15, QKI, ZCCHC8, NUMA1, NONO, FUBP1, DDX5, SPEN, RBM10, DDX3X, SND1, PRCC |
| nodular melanoma | 23/47 | 0.033511 | 1.38x | FUS, SF3B1, THRAP3, RNF213, A1CF, CRNKL1, EWSR1, HNRNPA2B1, RBM15, QKI, ZCCHC8, NUMA1, U2AF1, ZMYM3, NONO, FUBP1, SRSF2, DDX5, SPEN, RBM10 |
| superficial spreading melanoma | 22/45 | 0.037850 | 1.38x | SF3B1, THRAP3, RNF213, PCBP1, A1CF, CRNKL1, EWSR1, HNRNPA2B1, RBM15, QKI, NUMA1, U2AF1, ZMYM3, NONO, FUBP1, DDX5, SPEN, RBM10, SRSF3, DDX3X |
| multiple sclerosis | 17/33 | 0.038079 | 1.45x | PLRG1, SF3B1, ZC3HAV1, DHX30, SPEN, SREK1, SNRPD3, PCBP2, AKAP8L, SSB, RBM17, DDX1, SNRPD2, ZNF207, DDX19A, CDC5L, ESRP2 |
| central nervous system primitive neuroectodermal neoplasm | 24/50 | 0.038926 | 1.36x | FUS, SF3B1, THRAP3, SFPQ, RNF213, A1CF, PABPC1, CRNKL1, EWSR1, HNRNPA2B1, RBM15, QKI, NUMA1, U2AF1, ZMYM3, NONO, FUBP1, SRSF2, DDX5, SPEN |
| carcinoma of liver and intrahepatic biliary tract | 26/55 | 0.039515 | 1.33x | FUS, SF3B1, THRAP3, SFPQ, RNF213, A1CF, PABPC1, CRNKL1, EWSR1, HNRNPA2B1, RBM15, QKI, ZCCHC8, NUMA1, U2AF1, ZMYM3, NONO, FUBP1, SRSF2, DDX5 |
| lung carcinoma | 26/55 | 0.039515 | 1.33x | FUS, SF3B1, THRAP3, SFPQ, RNF213, A1CF, PABPC1, CRNKL1, EWSR1, HNRNPA2B1, QKI, ZCCHC8, NUMA1, U2AF1, RALY, ZMYM3, FUBP1, NONO, SRSF2, DDX5 |
| skin basal cell carcinoma | 26/55 | 0.039515 | 1.33x | FUS, SF3B1, THRAP3, SFPQ, RNF213, A1CF, PABPC1, CRNKL1, EWSR1, HNRNPA2B1, RBM15, QKI, ZCCHC8, NUMA1, U2AF1, ZMYM3, NONO, FUBP1, SRSF2, DDX5 |
| bile duct carcinoma | 26/55 | 0.039515 | 1.33x | FUS, SF3B1, THRAP3, SFPQ, RNF213, A1CF, PABPC1, CRNKL1, EWSR1, HNRNPA2B1, RBM15, QKI, ZCCHC8, NUMA1, U2AF1, ZMYM3, NONO, FUBP1, SRSF2, DDX5 |
| cecum adenocarcinoma | 26/55 | 0.039515 | 1.33x | FUS, SF3B1, THRAP3, SFPQ, RNF213, PCBP1, A1CF, PABPC1, CRNKL1, EWSR1, HNRNPA2B1, RBM15, QKI, ZCCHC8, NUMA1, U2AF1, ZMYM3, NONO, FUBP1, DDX5 |
| thyroid carcinoma | 26/55 | 0.039515 | 1.33x | FUS, SF3B1, THRAP3, SFPQ, RNF213, A1CF, PABPC1, CRNKL1, EWSR1, HNRNPA2B1, RBM15, QKI, ZCCHC8, NUMA1, U2AF1, ZMYM3, NONO, FUBP1, SRSF2, DDX5 |
| breast ductal adenocarcinoma | 28/60 | 0.039712 | 1.32x | FUS, SF3B1, THRAP3, SFPQ, RNF213, PCBP1, A1CF, PABPC1, CRNKL1, EWSR1, HNRNPA2B1, RBM15, QKI, ZCCHC8, NUMA1, U2AF1, AKAP1, ZMYM3, NONO, FUBP1 |
| Merkel cell skin cancer | 16/31 | 0.043015 | 1.46x | ZCCHC8, FUS, SF3B1, CRNKL1, SPEN, EWSR1, U2AF1, RBM10, SFPQ, ZMYM3, RNF213, FUBP1, A1CF, DDX3X, SND1, QKI |
| esophageal carcinoma | 13/24 | 0.043258 | 1.53x | NUMA1, FUS, SF3B1, DDX5, SPEN, EWSR1, RBM10, HNRNPA2B1, ZMYM3, RNF213, A1CF, DDX3X, SND1 |
| salivary gland adenoid cystic carcinoma | 13/24 | 0.043258 | 1.53x | NUMA1, SF3B1, FUBP1, CRNKL1, SPEN, U2AF1, SFPQ, DDX5, HNRNPA2B1, ZMYM3, NONO, DDX3X, SND1 |
| Gastric Adenoma | 13/24 | 0.043258 | 1.53x | ZCCHC8, FUS, NUMA1, CRNKL1, SPEN, THRAP3, SFPQ, ZMYM3, RNF213, QKI, DDX3X, SND1, PRCC |
| neoplasm | 50/117 | 0.043293 | 1.21x | NUDT21, SF3B1, SRSF1, DKC1, THRAP3, KHDRBS1, SFPQ, HNRNPK, RNF213, CPEB4, PCBP1, FMR1, EWSR1, ADAR, PPIH, SUGP1, HNRNPA2B1, UPF1, RBM15, YBX1 |
| small cell lung carcinoma | 23/48 | 0.043924 | 1.35x | FUS, SF3B1, SFPQ, RNF213, A1CF, PABPC1, CRNKL1, EWSR1, HNRNPA2B1, RBM15, QKI, ZCCHC8, NUMA1, ZMYM3, NONO, FUBP1, SRSF2, DDX5, SPEN, RBM10 |
| skin angiosarcoma | 3/3 | 0.044033 | 2.82x | SND1, DDX3X, RNF213 |
| gastric ulcer | 3/3 | 0.044033 | 2.82x | RBM33, HNRNPLL, SND1 |
💡 说明：
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集