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🔬 剪接因子 TFIP11 靶基因疾病富集分析
| 疾病名称 | Overlap | P-value | 富集倍数 | 相关靶基因 |
|---|---|---|---|---|
| salivary gland adenoid cystic carcinoma | 7/24 | 0.005213 | 3.02x | NUMA1, SF3B1, DDX5, SFPQ, HNRNPA2B1, NONO, DDX3X |
| dengue disease | 30/212 | 0.006164 | 1.46x | SF3B1, SNRPB, SF3B3, HNRNPK, DDX3X, HNRNPUL1, SNRPD2, PCBP1, PABPC1, SNRPF, CPSF7, SNRPE, HNRNPA2B1, HSPA8, YBX1, CCAR1, HNRNPC, HNRNPU, SRSF7, HNRNPA1 |
| isolated cerebellar hypoplasia/agenesis | 2/2 | 0.009219 | 10.34x | DDX3X, DKC1 |
| medulloblastoma | 4/10 | 0.010705 | 4.14x | SF3B1, CCAR1, DDX3X, NONO |
| prostate cancer | 4/10 | 0.010705 | 4.14x | YBX1, CPSF7, AKAP1, SF3B3 |
| nasopharyngeal squamous cell carcinoma | 7/29 | 0.015863 | 2.5x | NUMA1, SF3B1, DDX5, SFPQ, HNRNPA2B1, DDX3X, PABPC1 |
| breast ductal adenocarcinoma | 11/60 | 0.021501 | 1.9x | NUMA1, SF3B1, SRSF2, DDX5, SFPQ, AKAP1, PCBP1, HNRNPA2B1, NONO, DDX3X, PABPC1 |
| Familial prostate cancer | 3/7 | 0.022765 | 4.43x | CPSF7, AKAP1, SF3B3 |
| Gallbladder Adenocarcinoma | 8/38 | 0.022789 | 2.18x | NUMA1, SF3B1, DDX5, SFPQ, HNRNPA2B1, NONO, DDX3X, PABPC1 |
| cutaneous melanoma | 11/61 | 0.024222 | 1.86x | NUMA1, SF3B1, SRSF2, DDX5, SFPQ, PCBP1, HNRNPA2B1, RALY, NONO, DDX3X, PABPC1 |
| B-cell acute lymphoblastic leukemia | 9/46 | 0.025173 | 2.02x | NUMA1, SF3B1, SRSF2, DDX5, SFPQ, HNRNPA2B1, NONO, DDX3X, PABPC1 |
| distal myopathy | 2/3 | 0.025926 | 6.89x | HNRNPA1, MATR3 |
| X-linked syndromic intellectual disability | 2/3 | 0.025926 | 6.89x | DDX3X, NONO |
| hepatocellular carcinoma | 17/113 | 0.029651 | 1.56x | NUMA1, SF3B1, HNRNPC, SRSF2, HNRNPA1, DDX5, SFPQ, HNRNPK, PCBP1, HNRNPA2B1, HNRNPD, HSPA8, NONO, YBX1, DDX3X, DDX17, PABPC1 |
| melanoma | 10/55 | 0.029980 | 1.88x | NUMA1, SF3B1, SRSF2, DDX5, SFPQ, RALY, NONO, YBX1, DDX3X, PABPC1 |
| lung carcinoma | 10/55 | 0.029980 | 1.88x | NUMA1, SF3B1, SRSF2, DDX5, SFPQ, HNRNPA2B1, RALY, NONO, DDX3X, PABPC1 |
| lung adenocarcinoma | 11/63 | 0.030419 | 1.81x | NUMA1, SF3B1, SRSF2, DDX5, SFPQ, PCBP1, HNRNPA2B1, NONO, YBX1, DDX3X, PABPC1 |
| breast carcinoma | 11/63 | 0.030419 | 1.81x | NUMA1, SF3B1, SRSF2, DDX5, ZC3H11A, SFPQ, HNRNPA2B1, RALY, NONO, DDX3X, PABPC1 |
| HER2 Positive Breast Carcinoma | 8/40 | 0.030600 | 2.07x | NUMA1, SF3B1, SRSF2, SFPQ, HNRNPA2B1, PCBP1, DDX3X, PABPC1 |
| small cell lung carcinoma | 9/48 | 0.032696 | 1.94x | NUMA1, SF3B1, SRSF2, DDX5, SFPQ, HNRNPA2B1, NONO, DDX3X, PABPC1 |
| lymphoid neoplasm | 10/57 | 0.037749 | 1.81x | NUMA1, SF3B1, SRSF2, DDX5, SFPQ, PCBP1, HNRNPA2B1, NONO, DDX3X, PABPC1 |
| cervical squamous cell carcinoma | 10/57 | 0.037749 | 1.81x | NUMA1, SF3B1, SRSF2, DDX5, SFPQ, PCBP1, HNRNPA2B1, NONO, DDX3X, PABPC1 |
| central nervous system primitive neuroectodermal neoplasm | 9/50 | 0.041678 | 1.86x | NUMA1, SF3B1, SRSF2, DDX5, SFPQ, HNRNPA2B1, NONO, DDX3X, PABPC1 |
| rectal adenocarcinoma | 10/58 | 0.042124 | 1.78x | NUMA1, SF3B1, SRSF2, DDX5, SFPQ, PCBP1, HNRNPA2B1, NONO, DDX3X, PABPC1 |
| papillary renal cell carcinoma | 8/43 | 0.045536 | 1.92x | NUMA1, SF3B1, SRSF2, DDX5, SFPQ, HNRNPA2B1, PCBP1, DDX3X |
| bladder transitional cell carcinoma | 10/59 | 0.046840 | 1.75x | NUMA1, SF3B1, SRSF2, DDX5, SFPQ, PCBP1, HNRNPA2B1, NONO, DDX3X, PABPC1 |
| colon adenocarcinoma | 10/59 | 0.046840 | 1.75x | NUMA1, SF3B1, SRSF2, DDX5, SFPQ, PCBP1, HNRNPA2B1, NONO, DDX3X, PABPC1 |
| pancreatic ductal adenocarcinoma | 10/59 | 0.046840 | 1.75x | NUMA1, SF3B1, SRSF2, DDX5, SFPQ, PCBP1, HNRNPA2B1, NONO, DDX3X, PABPC1 |
| gastric adenocarcinoma | 10/59 | 0.046840 | 1.75x | NUMA1, SF3B1, SRSF2, DDX5, SFPQ, PCBP1, HNRNPA2B1, NONO, DDX3X, PABPC1 |
| Endometrial Endometrioid Adenocarcinoma | 10/59 | 0.046840 | 1.75x | NUMA1, SF3B1, SRSF2, DDX5, SFPQ, PCBP1, HNRNPA2B1, NONO, DDX3X, PABPC1 |
💡 说明：
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集