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🔬 剪接因子 XRN2 靶基因疾病富集分析
| 疾病名称 | Overlap | P-value | 富集倍数 | 相关靶基因 |
|---|---|---|---|---|
| gastric intestinal type adenocarcinoma | 17/41 | 0.001343 | 2.01x | NUMA1, FUS, SRSF2, FUBP1, PABPC1, DDX5, U2AF1, EWSR1, RBM10, HNRNPA2B1, ZMYM3, QKI, RNF213, NONO, DDX3X, SND1, PRCC |
| hepatocellular carcinoma | 35/113 | 0.002676 | 1.5x | FUS, SRSF1, KHDRBS1, SFPQ, HNRNPK, RNF213, PRPF19, DDX17, PABPC1, EIF4A3, SRSF10, PTBP1, ELAVL1, EWSR1, CPSF6, HNRNPA2B1, YBX1, QKI, NUMA1, HNRNPC |
| non-small cell lung carcinoma | 21/58 | 0.002856 | 1.76x | FUS, SFPQ, RNF213, EWSR1, HNRNPA2B1, YBX1, QKI, NUMA1, RBM5, U2AF1, ZMYM3, NONO, AGO2, FUBP1, SRSF2, DDX5, RBM10, SRSF3, DDX3X, SND1 |
| bile duct adenocarcinoma | 17/45 | 0.004491 | 1.83x | NUMA1, FUS, FUBP1, DDX5, U2AF1, EWSR1, SFPQ, RBM10, HNRNPA2B1, ZMYM3, QKI, RNF213, NONO, SRSF3, DDX3X, SND1, PABPC1 |
| Gallbladder Adenocarcinoma | 15/38 | 0.004710 | 1.92x | NUMA1, FUS, FUBP1, PABPC1, DDX5, U2AF1, SFPQ, RBM10, HNRNPA2B1, ZMYM3, RNF213, NONO, DDX3X, SND1, PRCC |
| brain glioblastoma | 19/53 | 0.005272 | 1.74x | FUS, SFPQ, RNF213, PABPC1, EWSR1, HNRNPA2B1, QKI, NUMA1, U2AF1, ZMYM3, FUBP1, NONO, SRSF2, DDX5, RBM10, SRSF3, DDX3X, SND1, PRCC |
| neoplasm | 35/117 | 0.005288 | 1.45x | SRSF1, RBM38, DKC1, KHDRBS1, SFPQ, HNRNPK, RNF213, MBNL1, ELAVL1, EWSR1, HNRNPA2B1, NXF1, YBX1, QKI, RBM3, HNRNPU, HNRNPC, PHF5A, RBM5, CDK10 |
| genetic disorder | 34/113 | 0.005456 | 1.46x | FUS, SRSF1, HNRNPK, IK, U2AF2, RNF213, PRPF19, EIF4A3, DHX30, HNRNPA2B1, SF3B2, HNRNPU, FAM50A, PHF5A, HNRNPC, CDK10, SNRNP200, HNRNPA1, SRRM2, TMEM63A |
| B-cell acute lymphoblastic leukemia | 17/46 | 0.005864 | 1.79x | NUMA1, FUS, SRSF2, DDX5, U2AF1, EWSR1, SFPQ, RBM10, HNRNPA2B1, ZMYM3, QKI, RNF213, NONO, SRSF3, DDX3X, SND1, PABPC1 |
| gastroesophageal junction adenocarcinoma | 15/39 | 0.006303 | 1.87x | NUMA1, FUS, SRSF2, FUBP1, PABPC1, DDX5, U2AF1, RBM10, HNRNPA2B1, ZMYM3, QKI, RNF213, SRSF3, SND1, PRCC |
| central nervous system primitive neuroectodermal neoplasm | 18/50 | 0.006319 | 1.75x | NUMA1, FUS, SRSF2, FUBP1, PABPC1, DDX5, U2AF1, EWSR1, SFPQ, RBM10, HNRNPA2B1, ZMYM3, QKI, RNF213, NONO, DDX3X, SND1, PRCC |
| Duodenal Adenocarcinoma | 16/43 | 0.006986 | 1.81x | NUMA1, FUS, FUBP1, DDX5, U2AF1, EWSR1, SFPQ, RBM10, HNRNPA2B1, ZMYM3, QKI, RNF213, NONO, DDX3X, SND1, PRCC |
| Atypical Meningioma | 9/19 | 0.007247 | 2.3x | FUS, PABPC1, DDX5, RBM10, RNF213, FUBP1, DDX3X, SND1, PRCC |
| Rectal Tubular Adenoma | 7/13 | 0.007656 | 2.61x | SRSF2, EWSR1, RBM10, ZMYM3, RNF213, SND1, QKI |
| Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation | 18/51 | 0.008039 | 1.71x | NUMA1, FUS, SRSF2, FUBP1, PABPC1, U2AF1, EWSR1, SFPQ, RBM10, HNRNPA2B1, ZMYM3, QKI, RNF213, NONO, SRSF3, DDX3X, SND1, PRCC |
| melanoma | 19/55 | 0.008419 | 1.68x | FUS, SFPQ, RNF213, PABPC1, EWSR1, YBX1, QKI, NUMA1, CDK10, U2AF1, ZMYM3, FUBP1, NONO, SRSF2, DDX5, RBM10, DDX3X, SND1, PRCC |
| skin basal cell carcinoma | 19/55 | 0.008419 | 1.68x | FUS, SFPQ, RNF213, PABPC1, EWSR1, HNRNPA2B1, QKI, NUMA1, U2AF1, ZMYM3, FUBP1, NONO, SRSF2, DDX5, RBM10, SRSF3, DDX3X, SND1, PRCC |
| lung carcinoma | 19/55 | 0.008419 | 1.68x | FUS, SFPQ, RNF213, PABPC1, EWSR1, HNRNPA2B1, QKI, NUMA1, U2AF1, ZMYM3, FUBP1, NONO, SRSF2, DDX5, RBM10, SRSF3, DDX3X, SND1, PRCC |
| thyroid carcinoma | 19/55 | 0.008419 | 1.68x | FUS, SFPQ, RNF213, PABPC1, EWSR1, HNRNPA2B1, QKI, NUMA1, U2AF1, ZMYM3, FUBP1, NONO, SRSF2, DDX5, RBM10, SRSF3, DDX3X, SND1, PRCC |
| carcinoma of liver and intrahepatic biliary tract | 19/55 | 0.008419 | 1.68x | FUS, SFPQ, RNF213, PABPC1, EWSR1, HNRNPA2B1, QKI, NUMA1, U2AF1, ZMYM3, FUBP1, NONO, SRSF2, DDX5, RBM10, SRSF3, DDX3X, SND1, PRCC |
| bile duct carcinoma | 19/55 | 0.008419 | 1.68x | FUS, SFPQ, RNF213, PABPC1, EWSR1, HNRNPA2B1, QKI, NUMA1, U2AF1, ZMYM3, FUBP1, NONO, SRSF2, DDX5, RBM10, SRSF3, DDX3X, SND1, PRCC |
| skin angiosarcoma | 3/3 | 0.008575 | 4.86x | DDX3X, SND1, RNF213 |
| gastric ulcer | 3/3 | 0.008575 | 4.86x | RBM33, HNRNPLL, SND1 |
| acute myeloid leukemia | 21/63 | 0.008924 | 1.62x | FUS, SFPQ, U2AF2, RNF213, PABPC1, EWSR1, HNRNPA2B1, QKI, NUMA1, U2AF1, ZMYM3, NONO, FUBP1, SRSF2, DDX5, RBM10, SRSF3, DDX41, DDX3X, SND1 |
| breast carcinoma | 21/63 | 0.008924 | 1.62x | FUS, SFPQ, RNF213, PABPC1, EWSR1, HNRNPA2B1, QKI, FAM50A, NUMA1, U2AF1, ZMYM3, NONO, FUBP1, SRSF2, DDX5, ZC3H11A, RBM10, SRSF3, DDX3X, SND1 |
| papillary thyroid carcinoma | 17/48 | 0.009640 | 1.72x | NUMA1, FUS, SRSF2, FUBP1, PABPC1, U2AF1, EWSR1, SFPQ, RBM10, ZMYM3, QKI, RNF213, NONO, SRSF3, DDX3X, SND1, PRCC |
| small cell lung carcinoma | 17/48 | 0.009640 | 1.72x | NUMA1, FUS, SRSF2, FUBP1, PABPC1, DDX5, EWSR1, SFPQ, RBM10, HNRNPA2B1, ZMYM3, QKI, RNF213, NONO, DDX3X, SND1, PRCC |
| ovarian serous adenocarcinoma | 18/52 | 0.010120 | 1.68x | NUMA1, FUS, SRSF2, FUBP1, PABPC1, DDX5, U2AF1, EWSR1, SFPQ, RBM10, HNRNPA2B1, ZMYM3, RNF213, SRSF3, NONO, DDX3X, SND1, PRCC |
| gastric carcinoma | 19/56 | 0.010487 | 1.65x | FUS, SFPQ, RNF213, PABPC1, EWSR1, HNRNPA2B1, QKI, NUMA1, U2AF1, ZMYM3, FUBP1, NONO, SRSF2, DDX5, RBM10, SRSF3, DDX3X, SND1, PRCC |
| oral cavity carcinoma | 15/41 | 0.010785 | 1.78x | NUMA1, FUS, FUBP1, PABPC1, U2AF1, EWSR1, RBM10, ZMYM3, QKI, RNF213, NONO, SRSF3, DDX3X, SND1, PRCC |
💡 说明：
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集