🔬 剪接因子 YBX1 靶基因疾病富集分析

疾病名称	Overlap	P-value	富集倍数	相关靶基因
neurodegenerative disease	177/422	0.002141	1.11x	RBM15B, SF3B1, SRSF1, RBM38, DHX38, SAMD4B, RBM22, HNRNPK, RBM17, PRPF19, DDX17, PABPC1, MBNL1, BUD13, DHX30, LUC7L3, SART3, CTNNBL1, EIF4B, LSM4
Intellectual disability	30/57	0.012850	1.39x	SNRPB, SRSF1, HNRNPK, U2AF2, SF3B4, FMR1, DDX17, PABPC1, EIF4A3, PQBP1, DHX30, HNRNPUL2, THOC6, ZFR, UPF1, THOC2, FAM50A, HNRNPU, PUF60, ZMYM3
angina pectoris	4/4	0.020337	2.64x	SF3A3, RNF213, DHX38, BUD13
Gastric Adenoma	14/24	0.031206	1.54x	ZCCHC8, FUS, NUMA1, CRNKL1, SPEN, THRAP3, SFPQ, ZMYM3, RNF213, QKI, DDX6, DDX3X, SND1, PRCC
genetic disorder	52/113	0.032902	1.21x	FUS, SNRPB, SRSF1, HNRNPK, IK, U2AF2, RNF213, PCBP1, SF3B4, PRPF19, FMR1, RNF34, EIF4A3, PQBP1, DHX30, HNRNPUL2, THOC6, ADAR, HNRNPA2B1, THOC2
coronary atherosclerosis	6/8	0.037128	1.98x	SF3A3, GPATCH3, ADAR, CPEB4, AGO2, BUD13
medulloblastoma	7/10	0.039582	1.85x	SF3B1, ZMYM3, RNF213, NONO, DDX6, CCAR1, DDX3X
microcephaly	8/12	0.040177	1.76x	PQBP1, AAR2, DHX30, ADAR, DHX34, RBM28, DDX3X, TRA2B

💡 说明：
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集