🔬 剪接因子 YBX1 靶基因疾病富集分析

疾病名称	Overlap	P-value	富集倍数	相关靶基因
neurodegenerative disease	177/422	0.002141	1.11x	SNRNP25, CHERP, CDC5L, SRSF3, MATR3, HNRNPF, SART3, SAFB2, SF3A1, HTATSF1, RNF20, RBM39, SRRM1, THOC5, NXF1, ZCRB1, RBM22, RBM27, GEMIN5, DHX38
Intellectual disability	30/57	0.012850	1.39x	SF3B4, HNRNPUL2, AGO2, FAM50A, DDX23, PABPC1, PUF60, SNRPB, HNRNPD, THOC2, FMR1, UPF1, DDX6, CSTF2, ZFR, ZMYM3, HNRNPK, RBM10, PQBP1, SRSF1
angina pectoris	4/4	0.020337	2.64x	BUD13, DHX38, SF3A3, RNF213
Gastric Adenoma	14/24	0.031206	1.54x	FUS, DDX6, DDX3X, PRCC, NUMA1, CRNKL1, ZCCHC8, RNF213, SFPQ, QKI, SND1, SPEN, ZMYM3, THRAP3
genetic disorder	52/113	0.032902	1.21x	NONO, SF3B4, HNRNPUL2, HNRNPA2B1, AGO2, MATR3, RAVER1, TARDBP, FAM50A, DDX23, PHF5A, SPEN, HNRNPC, PUF60, SNRPB, EFTUD2, THOC2, GEMIN5, RBMX, FMR1
coronary atherosclerosis	6/8	0.037128	1.98x	GPATCH3, AGO2, SF3A3, BUD13, ADAR, CPEB4
medulloblastoma	7/10	0.039582	1.85x	CCAR1, NONO, DDX6, SF3B1, DDX3X, RNF213, ZMYM3
microcephaly	8/12	0.040177	1.76x	DDX3X, RBM28, DHX34, TRA2B, ADAR, DHX30, AAR2, PQBP1

💡 说明：
• Overlap: 靶基因中与该疾病相关的基因数 / 数据库中该疾病总关联基因数
• P-value: 超几何检验显著性，越小代表富集越显著
• 富集倍数: 实际关联数 / 期望关联数，>1 表示富集