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🧬 基因注释:A1CF

📝 官方信息

官方名称:APOBEC1 complementation factor

功能摘要:Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by this gene. The gene product has three non-identical RNA recognition motifs and belongs to the hnRNP R family of RNA-binding proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks APOBEC-1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA editing or RNA processing events. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Nov 2010].

🎯 作为靶基因的剪接因子
  • HNRNPA1 综合评分: 0.350 · 证据 2 条
  • HNRNPC 综合评分: 0.350 · 证据 2 条
  • HNRNPK 综合评分: 0.300 · 证据 2 条
  • HNRNPL 综合评分: 0.300 · 证据 2 条
  • KHSRP 综合评分: 0.300 · 证据 2 条
  • RBFOX2 综合评分: 0.300 · 证据 2 条
  • SRSF9 综合评分: 0.300 · 证据 1 条
  • PCBP2 综合评分: 0.298 · 证据 1 条
  • TIA1 综合评分: 0.250 · 证据 1 条
  • PRPF8 综合评分: 0.200 · 证据 1 条
  • U2af2 综合评分: 0.162 · 证据 1 条
  • PRPF4 综合评分: 0.150 · 证据 1 条
  • Srsf1 综合评分: 0.150 · 证据 1 条
  • U2af1 综合评分: 0.150 · 证据 1 条
  • A1CF 综合评分: 0.100 · 证据 1 条
  • HNRNPUL1 综合评分: 0.100 · 证据 1 条
  • RBM20 综合评分: 0.100 · 证据 2 条
🏥 关联疾病
gout
中关联 (0.535)
colorectal cancer
中关联 (0.428)
familial hyperlipidemia
中关联 (0.421)
colorectal adenoma
低关联 (0.327)
type 2 diabetes mellitus
低关联 (0.314)
skull disorder
低关联 (0.302)
renal dialysis
低关联 (0.290)
esophageal adenocarcinoma
低关联 (0.199)
hepatocellular carcinoma
低关联 (0.199)
melanoma
低关联 (0.195)
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