🧬 基因注释：ACIN1
📝 官方信息
官方名称：apoptotic chromatin condensation inducer 1
功能摘要：Apoptosis is defined by several morphologic nuclear changes, including chromatin condensation and nuclear fragmentation. This gene encodes a nuclear protein that induces apoptotic chromatin condensation after activation by caspase-3, without inducing DNA fragmentation. This protein has also been shown to be a component of a splicing-dependent multiprotein exon junction complex (EJC) that is deposited at splice junctions on mRNAs, as a consequence of pre-mRNA splicing. It may thus be involved in mRNA metabolism associated with splicing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011].
🎯 作为靶基因的剪接因子
- HNRNPA1 综合评分: 0.510 · 证据 2 条
- HNRNPH1 综合评分: 0.494 · 证据 2 条
- RBFOX2 综合评分: 0.444 · 证据 2 条
- SRSF2 综合评分: 0.424 · 证据 1 条
- HNRNPA2B1 综合评分: 0.412 · 证据 2 条
- HNRNPC 综合评分: 0.412 · 证据 2 条
- Srsf3 综合评分: 0.398 · 证据 1 条
- HNRNPM 综合评分: 0.350 · 证据 2 条
- MBNL1 综合评分: 0.350 · 证据 2 条
- QKI 综合评分: 0.350 · 证据 1 条
- PCBP2 综合评分: 0.344 · 证据 1 条
- U2af1 综合评分: 0.324 · 证据 1 条
- EWSR1 综合评分: 0.312 · 证据 2 条
- Srsf1 综合评分: 0.310 · 证据 1 条
- UPF1 综合评分: 0.306 · 证据 1 条
- FUS 综合评分: 0.300 · 证据 1 条
- HNRNPK 综合评分: 0.300 · 证据 2 条
- HNRNPL 综合评分: 0.300 · 证据 2 条
- KHSRP 综合评分: 0.300 · 证据 2 条
- PTBP1 综合评分: 0.300 · 证据 2 条
🏥 关联疾病
neurodegenerative disease
中关联 (0.548)