🧬 基因注释：AICDA
📝 官方信息
官方名称：activation induced cytidine deaminase
功能摘要：This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. AICDA is specifically expressed and active in germinal center-like B cells. In the germinal center, AICDA is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. An epigenetic role in neoplastic transformation and lymphoma progression has been experimentally ascribed to AICDA using mouse models. Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2). [provided by RefSeq, Jul 2020].
🎯 作为靶基因的剪接因子
- U2af1 综合评分: 0.150 · 证据 1 条
🏥 关联疾病
该基因暂无关联疾病记录