🧬 基因注释：APOC3
官方名称：apolipoprotein C3
功能摘要：This gene encodes a protein component of triglyceride (TG)-rich lipoproteins (TRLs) including very low density lipoproteins (VLDL), high density lipoproteins (HDL) and chylomicrons. The encoded protein plays a role in role in the metabolism of these TRLs through multiple modes. This protein has been shown to promote the secretion of VLDL1, inhibit lipoprotein lipase enzyme activity, and delay catabolism of TRL remnants. Mutations in this gene are associated with low plasma triglyceride levels and reduced risk of ischemic cardiovascular disease, and hyperalphalipoproteinemia, which is characterized by elevated levels of high density lipoprotein (HDL) and HDL cholesterol in human patients. This gene and other related genes comprise an apolipoprotein gene cluster on chromosome 11. [provided by RefSeq, Sep 2017].
- HNRNPK 综合评分: 0.362 · 证据 2 条
- SRSF9 综合评分: 0.300 · 证据 1 条
- PCBP1 综合评分: 0.262 · 证据 2 条
- PRPF8 综合评分: 0.262 · 证据 1 条
- SF3A3 综合评分: 0.262 · 证据 1 条
- AQR 综合评分: 0.212 · 证据 1 条
- PRPF4 综合评分: 0.212 · 证据 1 条
- PCBP2 综合评分: 0.200 · 证据 1 条
- UPF1 综合评分: 0.162 · 证据 1 条
- Srsf1 综合评分: 0.150 · 证据 1 条
- U2af1 综合评分: 0.150 · 证据 1 条
- PABPN1 综合评分: 0.100 · 证据 1 条
该基因暂无关联疾病记录