🧬 基因注释：ASPN
📝 官方信息
官方名称：asporin
功能摘要：This gene encodes a cartilage extracellular protein that is member of the small leucine-rich proteoglycan family. The encoded protein may regulate chondrogenesis by inhibiting transforming growth factor-beta 1-induced gene expression in cartilage. This protein also binds collagen and calcium and may induce collagen mineralization. Polymorphisms in the aspartic acid repeat region of this gene are associated with a susceptibility to osteoarthritis, and also with intervertebral disc disease. Alternative splicing of this gene results in multiple transcript variants.[provided by RefSeq, Jul 2014].
🎯 作为靶基因的剪接因子
- Tardbp 综合评分: 0.150 · 证据 1 条
🏥 关联疾病
该基因暂无关联疾病记录