🧬 基因注释：ATF4
官方名称：activating transcription factor 4
功能摘要：This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. [provided by RefSeq, Sep 2011].
- HNRNPA1 综合评分: 0.448 · 证据 2 条
- RBFOX2 综合评分: 0.444 · 证据 2 条
- Srsf3 综合评分: 0.444 · 证据 1 条
- HNRNPK 综合评分: 0.424 · 证据 2 条
- Tardbp 综合评分: 0.413 · 证据 1 条
- HNRNPC 综合评分: 0.412 · 证据 2 条
- HNRNPH1 综合评分: 0.412 · 证据 2 条
- U2af1 综合评分: 0.408 · 证据 1 条
- PTBP1 综合评分: 0.398 · 证据 2 条
- TIA1 综合评分: 0.394 · 证据 1 条
- KHSRP 综合评分: 0.362 · 证据 2 条
- Srsf2 综合评分: 0.362 · 证据 1 条
- PCBP2 综合评分: 0.360 · 证据 1 条
- HNRNPA2B1 综合评分: 0.350 · 证据 2 条
- MBNL1 综合评分: 0.350 · 证据 2 条
- PRPF8 综合评分: 0.324 · 证据 1 条
- U2af2 综合评分: 0.322 · 证据 1 条
- RBM10 综合评分: 0.312 · 证据 2 条
- RBM15 综合评分: 0.312 · 证据 2 条
- RBM39 综合评分: 0.312 · 证据 2 条
该基因暂无关联疾病记录