🧬 基因注释：BIN1
官方名称：bridging integrator 1
功能摘要：This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in several transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described. [provided by RefSeq, Mar 2016].
- HNRNPA1 综合评分: 0.636 · 证据 2 条
- RBFOX2 综合评分: 0.586 · 证据 2 条
- MBNL1 综合评分: 0.464 · 证据 2 条
- PTBP1 综合评分: 0.414 · 证据 2 条
- QKI 综合评分: 0.407 · 证据 1 条
- SRSF1 综合评分: 0.407 · 证据 1 条
- Srsf1 综合评分: 0.407 · 证据 1 条
- CELF1 综合评分: 0.364 · 证据 1 条
- Celf1 综合评分: 0.364 · 证据 1 条
- celf1 综合评分: 0.364 · 证据 1 条
- TIAL1 综合评分: 0.357 · 证据 1 条
- HNRNPA2B1 综合评分: 0.350 · 证据 2 条
- HNRNPC 综合评分: 0.350 · 证据 2 条
- HNRNPF 综合评分: 0.350 · 证据 2 条
- HNRNPH1 综合评分: 0.350 · 证据 2 条
- HNRNPM 综合评分: 0.350 · 证据 2 条
- RBM25 综合评分: 0.350 · 证据 2 条
- NOVA1 综合评分: 0.324 · 证据 2 条
- TARDBP 综合评分: 0.307 · 证据 1 条
- TIA1 综合评分: 0.307 · 证据 1 条
该基因暂无关联疾病记录