🧬 基因注释：BRD2
官方名称：bromodomain containing 2
功能摘要：This gene encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of proteins. This protein associates with transcription complexes and with acetylated chromatin during mitosis, and it selectively binds to the acetylated lysine-12 residue of histone H4 via its two bromodomains. The gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3, but sequence comparison suggests that the protein is not involved in the immune response. This gene has been implicated in juvenile myoclonic epilepsy, a common form of epilepsy that becomes apparent in adolescence. Multiple alternatively spliced variants have been described for this gene. [provided by RefSeq, Dec 2010].
- RBFOX2 综合评分: 0.362 · 证据 2 条
- HNRNPC 综合评分: 0.350 · 证据 2 条
- Tardbp 综合评分: 0.346 · 证据 1 条
- Nova2 综合评分: 0.324 · 证据 1 条
- Ptbp2 综合评分: 0.298 · 证据 1 条
- RBM15 综合评分: 0.250 · 证据 2 条
- TIA1 综合评分: 0.250 · 证据 1 条
- Srsf3 综合评分: 0.248 · 证据 1 条
- Srsf2 综合评分: 0.212 · 证据 1 条
- Srsf4 综合评分: 0.212 · 证据 1 条
- UPF1 综合评分: 0.162 · 证据 1 条
- U2af1 综合评分: 0.150 · 证据 1 条
- Rbmx 综合评分: 0.100 · 证据 1 条
- U2af2 综合评分: 0.100 · 证据 1 条
该基因暂无关联疾病记录