🧬 基因注释：CDH1
官方名称：cadherin 1
功能摘要：This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. [provided by RefSeq, Nov 2015].
- HNRNPC 综合评分: 0.572 · 证据 2 条
- HNRNPA2B1 综合评分: 0.536 · 证据 2 条
- SRSF2 综合评分: 0.460 · 证据 1 条
- SRSF9 综合评分: 0.460 · 证据 1 条
- PTBP1 综合评分: 0.444 · 证据 2 条
- HNRNPM 综合评分: 0.412 · 证据 2 条
- QKI 综合评分: 0.412 · 证据 1 条
- HNRNPA1 综合评分: 0.350 · 证据 2 条
- HNRNPH1 综合评分: 0.350 · 证据 2 条
- Rnps1 综合评分: 0.342 · 证据 1 条
- TIA1 综合评分: 0.312 · 证据 1 条
- HNRNPK 综合评分: 0.300 · 证据 2 条
- RBFOX2 综合评分: 0.300 · 证据 2 条
- SRSF3 综合评分: 0.300 · 证据 1 条
- Srsf2 综合评分: 0.300 · 证据 1 条
- Srsf3 综合评分: 0.300 · 证据 1 条
- NOVA1 综合评分: 0.262 · 证据 2 条
- PCBP1 综合评分: 0.262 · 证据 2 条
- NXF1 综合评分: 0.260 · 证据 1 条
- U2af2 综合评分: 0.260 · 证据 1 条
该基因暂无关联疾病记录