🧬 基因注释：CDK2AP1

官方名称：cyclin dependent kinase 2 associated protein 1

功能摘要：The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012].

• FUS 综合评分: 0.506 · 证据 1 条
• RBFOX2 综合评分: 0.506 · 证据 2 条
• fus 综合评分: 0.506 · 证据 1 条
• PTBP1 综合评分: 0.424 · 证据 2 条
• HNRNPA2B1 综合评分: 0.412 · 证据 2 条
• QKI 综合评分: 0.412 · 证据 1 条
• ELAVL3 综合评分: 0.376 · 证据 1 条
• HNRNPC 综合评分: 0.350 · 证据 2 条
• HNRNPH1 综合评分: 0.350 · 证据 2 条
• MBNL1 综合评分: 0.350 · 证据 2 条
• TIA1 综合评分: 0.348 · 证据 1 条
• Mbnl2 综合评分: 0.344 · 证据 1 条
• PCBP2 综合评分: 0.324 · 证据 1 条
• RBM10 综合评分: 0.312 · 证据 2 条
• HNRNPK 综合评分: 0.300 · 证据 2 条
• HNRNPU 综合评分: 0.300 · 证据 2 条
• KHSRP 综合评分: 0.300 · 证据 2 条
• SRSF9 综合评分: 0.300 · 证据 1 条
• CSTF2 综合评分: 0.274 · 证据 2 条
• MBNL2 综合评分: 0.262 · 证据 1 条

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