🧬 基因注释：CFL1
📝 官方信息
官方名称：cofilin 1
功能摘要：The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM, Apr 2004].
🎯 作为靶基因的剪接因子
- PTBP1 综合评分: 0.514 · 证据 2 条
- HNRNPC 综合评分: 0.474 · 证据 2 条
- HNRNPM 综合评分: 0.474 · 证据 2 条
- TIA1 综合评分: 0.464 · 证据 1 条
- Srsf3 综合评分: 0.444 · 证据 1 条
- QKI 综合评分: 0.412 · 证据 1 条
- MBNL2 综合评分: 0.396 · 证据 1 条
- EWSR1 综合评分: 0.394 · 证据 2 条
- CELF2 综合评分: 0.372 · 证据 2 条
- ELAVL3 综合评分: 0.372 · 证据 1 条
- PCBP2 综合评分: 0.360 · 证据 1 条
- HNRNPA2B1 综合评分: 0.350 · 证据 2 条
- HNRNPH1 综合评分: 0.350 · 证据 2 条
- MBNL1 综合评分: 0.350 · 证据 2 条
- Rnps1 综合评分: 0.336 · 证据 1 条
- UPF1 综合评分: 0.314 · 证据 1 条
- RBM15 综合评分: 0.312 · 证据 2 条
- RBM39 综合评分: 0.312 · 证据 2 条
- FUS 综合评分: 0.300 · 证据 1 条
- HNRNPK 综合评分: 0.300 · 证据 2 条
🏥 关联疾病
该基因暂无关联疾病记录