🧬 基因注释：CISH

官方名称：cytokine inducible SH2 containing protein

功能摘要：The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008].

• HNRNPK 综合评分: 0.362 · 证据 2 条
• RBM15 综合评分: 0.312 · 证据 2 条
• HNRNPL 综合评分: 0.300 · 证据 2 条
• RBM22 综合评分: 0.250 · 证据 2 条
• AQR 综合评分: 0.212 · 证据 1 条
• PCBP1 综合评分: 0.200 · 证据 2 条
• PRPF8 综合评分: 0.200 · 证据 1 条
• CPSF6 综合评分: 0.150 · 证据 2 条
• PABPC4 综合评分: 0.150 · 证据 2 条
• Srsf1 综合评分: 0.150 · 证据 1 条
• CSTF2T 综合评分: 0.100 · 证据 2 条
• U2af2 综合评分: 0.100 · 证据 1 条
• UPF1 综合评分: 0.100 · 证据 1 条

该基因暂无关联疾病记录