基因注释 - CRLF2

官方信息

官方名称：cytokine receptor like factor 2

功能摘要：This gene encodes a member of the type I cytokine receptor family. The encoded protein is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) on chromosome 14, or with P2Y purinoceptor 8 gene (P2RY8) on the same X or Y chromosomes is associated with B-progenitor acute lymphoblastic leukemia (ALL) and Down syndrome ALL. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014].

作为靶基因的剪接因子

U2af1 综合评分: 0.150 · 证据 1 条

关联疾病

该基因暂无关联疾病记录

外部数据库链接

NCBI Gene GenBank Ensembl GeneCards UniProt

基因注释：CRLF2