🧬 基因注释：CTSL

官方名称：cathepsin L

功能摘要：The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Additionally, this protein cleaves the S1 subunit of the SARS-CoV-2 spike protein, which is necessary for entry of the virus into the cell. [provided by RefSeq, Aug 2020].

• HNRNPA2B1 综合评分: 0.412 · 证据 2 条
• Tardbp 综合评分: 0.398 · 证据 1 条
• TIA1 综合评分: 0.312 · 证据 1 条
• FUS 综合评分: 0.300 · 证据 1 条
• HNRNPU 综合评分: 0.300 · 证据 2 条
• RBFOX2 综合评分: 0.300 · 证据 2 条
• SRSF3 综合评分: 0.300 · 证据 1 条
• SRSF9 综合评分: 0.300 · 证据 1 条
• Srsf3 综合评分: 0.300 · 证据 1 条
• fus 综合评分: 0.300 · 证据 1 条
• PRPF8 综合评分: 0.262 · 证据 1 条
• EWSR1 综合评分: 0.250 · 证据 2 条
• FUBP1 综合评分: 0.250 · 证据 2 条
• RBM15 综合评分: 0.250 · 证据 2 条
• ELAVL3 综合评分: 0.244 · 证据 1 条
• Srsf1 综合评分: 0.212 · 证据 1 条
• Mbnl2 综合评分: 0.200 · 证据 1 条
• Tra2a 综合评分: 0.198 · 证据 1 条
• Tra2b 综合评分: 0.162 · 证据 1 条
• YBX1 综合评分: 0.162 · 证据 1 条

该基因暂无关联疾病记录