🧬 基因注释：CCNT1

官方名称：cyclin T1

功能摘要：This gene encodes a member of the highly conserved cyclin C subfamily. The encoded protein tightly associates with cyclin-dependent kinase 9, and is a major subunit of positive transcription elongation factor b (p-TEFb). In humans, there are multiple forms of positive transcription elongation factor b, which may include one of several different cyclins along with cyclin-dependent kinase 9. The complex containing the encoded cyclin and cyclin-dependent kinase 9 acts as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and is both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner are also involved in triggering transcript elongation through phosphorylation of the carboxy-terminal domain of the largest RNA polymerase II subunit. Overexpression of this gene is implicated in tumor growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013].

• FUS 综合评分: 0.424 · 证据 1 条
• fus 综合评分: 0.424 · 证据 1 条
• HNRNPA1 综合评分: 0.412 · 证据 2 条
• QKI 综合评分: 0.412 · 证据 1 条
• PTBP1 综合评分: 0.398 · 证据 2 条
• CELF2 综合评分: 0.372 · 证据 2 条
• HNRNPL 综合评分: 0.362 · 证据 2 条
• HNRNPU 综合评分: 0.362 · 证据 2 条
• Tardbp 综合评分: 0.356 · 证据 1 条
• HNRNPA2B1 综合评分: 0.350 · 证据 2 条
• HNRNPC 综合评分: 0.350 · 证据 2 条
• HNRNPH1 综合评分: 0.350 · 证据 2 条
• HNRNPM 综合评分: 0.350 · 证据 2 条
• EWSR1 综合评分: 0.348 · 证据 2 条
• NOVA1 综合评分: 0.324 · 证据 2 条
• RBM10 综合评分: 0.312 · 证据 2 条
• TIA1 综合评分: 0.312 · 证据 1 条
• HNRNPK 综合评分: 0.300 · 证据 2 条
• KHSRP 综合评分: 0.300 · 证据 2 条
• RBFOX2 综合评分: 0.300 · 证据 2 条

该基因暂无关联疾病记录