基因注释 - DDX20

📝 官方信息

官方名称：DEAD-box helicase 20

功能摘要：DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which has an ATPase activity and is a component of the survival of motor neurons (SMN) complex. This protein interacts directly with SMN, the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on RNPs. [provided by RefSeq, Jul 2008].

🎯 作为靶基因的剪接因子

FUS 综合评分: 0.424 · 证据 1 条
fus 综合评分: 0.424 · 证据 1 条
Tardbp 综合评分: 0.398 · 证据 1 条
HNRNPA2B1 综合评分: 0.350 · 证据 2 条
HNRNPC 综合评分: 0.350 · 证据 2 条
EWSR1 综合评分: 0.312 · 证据 2 条
HNRNPU 综合评分: 0.300 · 证据 2 条
KHSRP 综合评分: 0.300 · 证据 2 条
RBM10 综合评分: 0.250 · 证据 2 条
RBM15 综合评分: 0.250 · 证据 2 条
CSTF2 综合评分: 0.212 · 证据 2 条
PRPF8 综合评分: 0.200 · 证据 1 条
Ptbp2 综合评分: 0.200 · 证据 1 条
CSTF2T 综合评分: 0.198 · 证据 2 条
U2af2 综合评分: 0.198 · 证据 1 条
Rnps1 综合评分: 0.162 · 证据 1 条
ACIN1 综合评分: 0.150 · 证据 2 条
CPSF4 综合评分: 0.150 · 证据 2 条
CPSF6 综合评分: 0.150 · 证据 2 条
CPSF7 综合评分: 0.150 · 证据 2 条

🏥 关联疾病

type 2 diabetes mellitus

中关联 (0.401)

Abnormality of the skeletal system

低关联 (0.376)

multisite chronic pain

低关联 (0.309)

hypertension

低关联 (0.279)

Vertigo

低关联 (0.272)

essential hypertension

低关联 (0.259)

neurodegenerative disease

低关联 (0.120)

amyotrophic lateral sclerosis

低关联 (0.120)

atrial fibrillation

低关联 (0.104)

🔍 查看该基因的所有关联疾病

🔗 外部数据库链接

NCBI Gene GenBank Ensembl GeneCards UniProt

🧬 基因注释：DDX20