SpliceAtlasDB
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🧬 基因注释:DDX41

📝 官方信息

官方名称:DEAD-box helicase 41

功能摘要:DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a member of the DEAD box protein family and interacts with several spliceosomal proteins. In addition, the encoded protein may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. [provided by RefSeq, Jan 2017].

🎯 作为靶基因的剪接因子
🏥 关联疾病
DDX41-related hematologic malignancy predisposition syndrome
(0.801)
acute myeloid leukemia
(0.703)
myelodysplastic syndrome
(0.681)
refractory anemia with excess blasts
(0.584)
myeloid leukemia
(0.555)
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🔗 外部数据库链接