基因注释 - DDX41

📝 官方信息

官方名称：DEAD-box helicase 41

功能摘要：DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a member of the DEAD box protein family and interacts with several spliceosomal proteins. In addition, the encoded protein may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. [provided by RefSeq, Jan 2017].

🎯 作为靶基因的剪接因子

HNRNPA2B1 综合评分: 0.412 · 证据 2 条
HNRNPA1 综合评分: 0.350 · 证据 2 条
HNRNPH1 综合评分: 0.350 · 证据 2 条
MBNL1 综合评分: 0.350 · 证据 2 条
RBM39 综合评分: 0.312 · 证据 2 条
TIA1 综合评分: 0.312 · 证据 1 条
FUS 综合评分: 0.300 · 证据 1 条
PTBP1 综合评分: 0.300 · 证据 2 条
RBFOX2 综合评分: 0.300 · 证据 2 条
SRSF2 综合评分: 0.300 · 证据 1 条
SRSF9 综合评分: 0.300 · 证据 1 条
Srsf2 综合评分: 0.300 · 证据 1 条
fus 综合评分: 0.300 · 证据 1 条
PCBP2 综合评分: 0.298 · 证据 1 条
PRPF8 综合评分: 0.262 · 证据 1 条
ELAVL3 综合评分: 0.260 · 证据 1 条
EWSR1 综合评分: 0.250 · 证据 2 条
RBM10 综合评分: 0.250 · 证据 2 条
RBM15 综合评分: 0.250 · 证据 2 条
Rnps1 综合评分: 0.224 · 证据 1 条

🏥 关联疾病

DDX41-related hematologic malignancy predisposition syndrome

高关联 (0.801)

acute myeloid leukemia

高关联 (0.703)

myelodysplastic syndrome

中关联 (0.681)

refractory anemia with excess blasts

中关联 (0.584)

myeloid leukemia

中关联 (0.555)

genetic disorder

中关联 (0.554)

neurodegenerative disease

中关联 (0.509)

adult acute myeloid leukemia

中关联 (0.493)

chronic myelogenous leukemia

中关联 (0.464)

Kostmann syndrome

中关联 (0.462)

🔍 查看该基因的所有关联疾病

🔗 外部数据库链接

NCBI Gene GenBank Ensembl GeneCards UniProt

🧬 基因注释：DDX41